Relationship between Fetus Weight and Biochemical Marker Results that Tested for Aneuploidy Screening in the Second Trimester

Abstract

INTRODUCTIONIn terms of maternal and infant mortality and morbidity, when unfavorable obstetric outcomes are a concern, small for gestational age (SGA), intrauterine growth restriction (IUGR), macrosomia, premature birth, and preeclampsia are some of the major etiological factors. In terms of a newborn's health and development, considering the maternal risk factors that can be changed and the interventions that can be performed in order to prevent these factors, the development of tests that can predetermine a probable developmental delay is of great importance.We aimed to demonstrate whether there is a relationship between fetal birth weight and biological marker results (hCG: human chorionic gonadotropin; MSAFP: maternal serum alphafetoprotein; uE3: unconjugated estriol) in the maternal serum studied during aneuploidy screening in the second trimester. METHODSIn the present study, 425 pregnant women who had been admitted to the Ege Obstetrics and Gynecology Training and Research Hospital and who had completed their triple tests in our hospital and gave mature birth in 2009 were retrospectively examined. The infants were divided into five groups, namely 5, 10, 50, 90, and 95 percentiles, according to their birth weights. The number of patients in the groups was 26, 63, 359, 27, and 8, respectively. The babies who were suitable for inclusion in the 50th percentile group were considered as the control group. The results of hCG, AFP, and E3, which were used for the triple scan test in the second trimester, were found in the archive of our hospital laboratory, while the birth results were obtained from our hospital birth records.Babies with a fetal anomaly, pregnant women with gestational diabetes and hypertension, pregnant women who had chronic We aimed at determining whether there was a relationship between the fetus weight and biochemical markers (hCG, MSAFP, and unconjugateed estriol) results that were studied in the maternal serum during the aneuploidy screening in the second trimester.Methods: In our study, 425 pregnant women who had completed their triple scan tests and who gave mature birth in our Ege Obstetrics and Birth Training and Research Hospital were retrospectively examined. The babies were divided into groups that were suitable for 5%, 10%, 50%, 90%, and 95% according to their birth weight. The number of patients in the groups was 26, 63, 359, 27, and 8, respectively. The babies who were suitable for 50% were the control group. The results of hCG, AFP, and E3, which were used for the triple scan test in the second trimester, were found in the archive of our hospital. Babies who had fetal anomalies, pregnant women with gestational diabetes and hypertension, pregnant women who had chronical diseases, and those who smoked were excluded from the study.Results: In this study, the average birth weight of babies who were over 2 MoM for hCG 2963.75 g difference was found statistically meaningful. However, the birth weight of 2963.75 g was suitable to 10%-50%. When the average birth weight of the babies who...