Relationship between fibroblast growth factor and arrhythmogenesis in normotensive patients with polycystic kidney disease

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is the most common life-threatening genetic disease [1]. Cardiovascular disease is the leading cause of morbidity and mortality in patients with ADPKD, with over 80% of deaths attributable to coronary artery disease [2,3]. Left ventricular hypertrophy (LVH) is common in these patients, even in the absence of hypertension [4,5]. LVH is also ABSTRACT 106Objectives. Autosomal dominant polycystic kidney disease (ADPKD) is the most common life-threatening genetic disease. Recent prospective studies showed a powerful and dose dependent association between increasing FGF-23 levels and greater risk of mortality among chronic kidney disease patients. In this study, our aim is to evaluate electrocardiogram derived arrhythmogenesis markers such as Tp-e, Tp-e/QT and Tpe/QTc ratio ADPKD. Methods. Data of 31 patients with ADPKD and age-sex matched 26 healthy were gained for study. Electrocardiogram and echocardiogram measurements, various serum markers were compared between groups. Results. FGF-23 was significantly higher, and eGFR was significantly lower in the ADPKD patients. Myocardial thickness was also higher in ADPKD group. Corrected QT dispersion, Tpe, Tp-e/QT and Tp-e/QTc were also compared between groups. All indicators were significantly worse in ADPKD group. In the correlation analyzes, FGF-23 was significantly correlated with Tp-e, Tp-e/QT and p=0.003; r=0.472, p<0.0001; r=0.442, p=0.001, respectively). Conclusions. In this occasion, we suggest that FGF-23, which probably accumulates ventricular electrical remodeling, may be helpful for risk stratification in patients with ADPKD when used with other indicators. Myocardial cell de-arrangement and electrical remodelling due to fibrosis are suggested mechanisms for this effect.

Does Iron Deficiency Affect the Heart in Children?

“…The mean of the QT values was calculated. Corrected QT (QTc) was calculated using the Bazett formula: QT dis (ms)=QT duration/√RR interval 6. The difference between the longest and shortest QT and QTc were obtained as QT dispersion (QT dis) (ms) and corrected QT dispersion (QTc dis) (ms) 9…”

“…Body mass index was calculated as weight (kg)/height (m 2 ). Systolic and diastolic blood pressure measurements were taken with a manual sphygmomanometer after resting for 5 to 15 minutes 6. All the study participants were evaluated with an electrocardiography (ECG), and echocardiography.…”

“…Corrected QT (QTc) was calculated using the Bazett formula: QT dis (ms) = QT duration/√RR interval. 6 The difference between the longest and shortest QT and QTc were obtained as QT dispersion (QT dis) (ms) and corrected QT dispersion (QTc dis) (ms). 9 The Tp-Te interval was defined as the distance from the peak point of the T wave to the point at which the descending arm of the T wave intersects the isoelectric line, and the mean value was obtained by measuring all the chest derivations which could be selected.…”