Relationship Between Gender and 1-Year Mortality in ANCA-Associated Vasculitis Patients: A Single-Center Retrospective Analysis and Meta-Analysis

Zhu, Qing; Li, Fen; Dong-xing, Xie; Chen, Bilin; Yu, Qianwen; Wei, Yusong; Ge, Yan L

doi:10.3389/fmed.2022.945011

Cited by 2 publications

(2 citation statements)

References 49 publications

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“…The scores were not influenced by AAV phenotype or disease duration. These results are comparable to those found by Robson et al [ 6 ], thus supporting the validity of a sex-based approach in AAV research [ 9 ]. Considering that disease activity was similar in our cohort [BVASv3: 0 (IQR 0–3)], the differences observed between sexes might have a clinically meaningful impact.…”

Section: Discussionsupporting

confidence: 90%

Validation of the Italian version of the ANCA-associated vasculitis patient-reported outcome (AAV-PRO) questionnaire

Treppo,

Isola,

De Martino

et al. 2023

Rheumatology Advances in Practice

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Objectives The primary objective of this study is the translation and validation of the ANCA-associated vasculitis patient-reported outcome (AAV-PRO) questionnaire into Italian, denoted as AAV-PRO_ita. The secondary objective is to evaluate the impact of AAV on Quality of Life(QoL) and work impairment in a large cohort of Italian patients. Methods The study design employs a prospective cohort study approach. First, the AAV-PRO was translated into Italian following the step guidelines for translations. The new AAV-PRO_ita questionnaire covers 3 disease domains: (a)organ-specific and systemic symptoms and signs(SSS); (b)physical function(PF); and (c)social and emotional impact(SEI). Secondly, Italian-speaking AAV patients were recruited from 17 Italian Centres, belonging to the Italian Vasculitis Study Group. Participants completed the AAV-PRO_ita questionnaire at 3 different time-points. Additionally, participants were also requested to complete the WPAI: GH. Results A total of 276 AAV-patients(56.5% women) completed the questionnaires. The AAV-PRO_ita questionnaire demonstrated a good internal consistency and test-retest reliability. Female AAV patients scored higher(ie worse) in all 3 domains, especially in the SEI domain(p-value < 0.001). Patients on GC therapy(n = 199) had higher scores on all domains, especially in the PF domain(p-value < 0.001), compared with patients without GC therapy(n = 77). Furthermore, patients who had at least one relapse of disease(n = 114) had higher scores compared with those who had never had one(n = 161) on any domains(p-value < 0.05). Finally, nearly 30% of the patients reported work impairment. Conclusions The AAV-PRO_ita questionnaire is a new 29-item, disease-specific PRO measuring tool which can be used in AAV research in the Italian language. Gender, GCs and relapsing disease showed the greatest impact on QoL.

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Section: Discussionsupporting

confidence: 90%

Validation of the Italian version of the ANCA-associated vasculitis patient-reported outcome (AAV-PRO) questionnaire

Treppo,

Isola,

De Martino

et al. 2023

Rheumatology Advances in Practice

View full text Add to dashboard Cite

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“…However, in terms of ALD, no research on their relationships has been reported yet. Although, among the parameters of ANI, the contribution of AST and male sex at diagnosis to the estimation of all-cause mortality was demonstrated in patients with systemic vasculitis to date [ 17 , 18 ]. Therefore, although ANI was developed as an index for distinguishing ALD from NAFLD, it could be reasonably speculated that ANI could be used to estimate poor outcomes during follow-up in patients with AAV.…”

Section: Introductionmentioning

confidence: 99%

Alcoholic Liver Disease/Nonalcoholic Fatty Liver Disease Index at Diagnosis Is Associated with All-Cause Mortality during Follow-Up in Patients with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

Cho,

Rah,

Song

et al. 2024

Medicina

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Background and Objectives: The purpose of this study was to investigate whether a new index related to chronic liver disease, the alcoholic liver disease/nonalcoholic fatty liver disease index (ANI) at diagnosis, is associated with all-cause mortality during follow-up in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). Materials and Methods: In this study, we included 270 patients with AAV. ANI was calculated using the following equation: ANI = −58.5 + 0.637 (adjusted mean corpuscular volume) + 3.91 (adjusted aspartate transaminase/alanine transaminase) − 0.406 (body mass index) + 6.35 (if male sex). All-cause mortality was defined as death from any cause during follow-up. Results: The median age of the 270 patients with AAV was 61.0 years (34.4% male and 66.6% female). The median ANI was significantly higher in deceased patients than in surviving patients. In the receiver operating characteristic curve analysis, ANI at diagnosis exhibited a statistically significant area under the curve for all-cause mortality during follow-up, and its cut-off was determined to be −0.59. Patients with ANI at diagnosis ≥ −0.59 exhibited a significantly higher risk for all-cause mortality and a significantly lower cumulative patient survival rate than those without. In the multivariable Cox analysis, ANI at diagnosis ≥ −0.59, together with age at diagnosis, was independently associated with all-cause mortality. Conclusions: This study is the first to demonstrate the predictive potential of ANI at diagnosis for all-cause mortality during follow-up in AAV patients without significant chronic liver diseases.

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Relationship Between Gender and 1-Year Mortality in ANCA-Associated Vasculitis Patients: A Single-Center Retrospective Analysis and Meta-Analysis

Cited by 2 publications

References 49 publications

Validation of the Italian version of the ANCA-associated vasculitis patient-reported outcome (AAV-PRO) questionnaire

Validation of the Italian version of the ANCA-associated vasculitis patient-reported outcome (AAV-PRO) questionnaire

Alcoholic Liver Disease/Nonalcoholic Fatty Liver Disease Index at Diagnosis Is Associated with All-Cause Mortality during Follow-Up in Patients with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

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