Relationship between hair cortisol concentrations and cognitive functioning in adolescents with ADHD

Llorens, Marta; Barba, Maria; Torralbas-Ortega, Jordi; Nadal, Roser; Armario, Antonio; Gagliano, Humberto; Urraca, Lara; Pujol, Susana; Montalvo, Itziar; Gracia, Rebeca; Polo, Diana; González-Riesco, Laura; Matalí, Josep Lluís; Palao, Diego; Pàmias, Montserrat; Labad, Javier

doi:10.1080/20008066.2023.2281752

Cited by 3 publications

(1 citation statement)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Llorens et al ( 2023 ) examined the relationship between hair cortisol concentrations (HCCs) and cognitive factors (i.e. attention and memory, and executive functioning) in adolescents with attention deficit and hyperactivity disorder (ADHD), and the moderating effects of sex and childhood trauma.…”

Section: In This Special Issuementioning

confidence: 99%

Sex and gender in psychotrauma research

Langeland,

Olff

2024

European Journal of Psychotraumatology

View full text Add to dashboard Cite

Section: In This Special Issuementioning

confidence: 99%

Sex and gender in psychotrauma research

Langeland,

Olff

2024

European Journal of Psychotraumatology

View full text Add to dashboard Cite

The effect of methylphenidate on the reproductive function of female rats

Cim,

Akyuz Cim

et al. 2024

J of Obstet and Gynaecol

View full text Add to dashboard Cite

AimResearch on the effects of methylphenidate on female fertility is limited. This study evaluated the effects of methylphenidate on reproductive function, oxidants, antioxidants, proinflammatory cytokines, prolactin, and cortisol in female rats.MethodsForty‐eight albino Wistar female rats were divided into four groups consisting of 12 rats, which were given pure water orally once daily for 7 days (HG‐1), 10 mg/kg methylphenidate orally once daily for 7 days (MP‐1), pure water orally once daily for 30 days (HG‐2), and 10 mg/kg methylphenidate orally once daily for 30 days (MP‐2). At the end of the treatment periods, tail vein blood was collected from six rats per group for prolactin and cortisol determination. Subsequently, euthanasia was performed and the ovaries were removed. Ovaries were analyzed for malondialdehyde (MDA), total glutathione (tGSH), superoxide dismutase (SOD), catalase (CAT), interleukin‐1 beta (IL‐1β), and tumor necrosis factor‐alpha (TNF‐α), and immunohistochemically. For breeding, the remaining six rats were mated with male rats for 1 month. Rats that failed to give birth were classed as infertile.ResultsA comparison of MP‐1 and MP‐2 groups to healthy controls revealed an elevation in MDA and corticosterone levels, and a decline in tGSH, SOD, and CAT levels (p < 0.001). Methylphenidate did not affect prolactin, IL‐1β, and TNF‐α levels (p > 0.05). MP‐1 and MP‐2 exhibited immunopositivity for 8‐hydroxy‐2'‐deoxyguanosine (8‐OHDG). MP‐2 rats developed 66.7% infertility while MP‐1, HG‐1, and HG‐2 rats did not.ConclusionIn ovaries, methylphenidate caused oxidative stress, but did not induce inflammation. Long‐term use of methylphenidate caused increased cortisol levels and infertility.

show abstract

Hair Cortisol Concentration and Mental Health During Childhood and Adolescence: evidence of higher cortisol concentration in ADHD symptoms in a large Brazilian population-based birth cohort

Tovo-Rodrigues,

Bierhals,

Goularte

et al. 2024

Preprint

View full text Add to dashboard Cite

Background: Childhood and adolescence are pivotal for mental health. The hypothalamic-pituitary-adrenal axis is the primary stress system, with chronic activation measurable via hair cortisol concentration (HCC), indicating long-term stress exposure. While elevated HCC is linked to adult mental health, its role in youth remains unclear. This study aims to assess the association between mental health symptoms in childhood and adolescence and HCC levels at age 15 in a Brazilian population-based cohort. Methods: We analyzed data from the 2004 Pelotas Birth Cohort, which includes 4,231 children followed from birth. At ages 6, 11 and 15 years, mental health symptoms were assessed using the Strengths and Difficulties Questionnaire (SDQ). At age 15, HCC was measured from 3 cm hair samples, and analyzed as ln (pg/mg). Linear regression models examined associations between HCC and SDQ scores, adjusting for perinatal variables, demographic factors, family income, maternal characteristics, maternal depression, harsh parenting exposure, hair traits, and corticosteroid use. The regression coefficient was exponentiated to improve interpretability. Results: SDQ total difficulties and conduct problems at age 6 were associated with HCC at age 15 in adjusted models (p<0.05). Hyperactivity/inattention symptoms at ages 6 (β=1.009 [1.001;1.018]) and 11 (β=1.013 [1.004;1.022]) were associated with HCC in the adjusted models. At age 15, the association between hyperactivity/inattention and HCC was associated with HCC in the partially adjusted model. (β=1.009 [1.000;1.017]). Conclusions: These associations emphasize the links between mental health and chronic stress over time, mainly an association between Attention-Deficit/Hyperactivity Disorder symptoms and higher concentration of HCC.

show abstract

Relationship between hair cortisol concentrations and cognitive functioning in adolescents with ADHD

Cited by 3 publications

References 54 publications

Sex and gender in psychotrauma research

Sex and gender in psychotrauma research

The effect of methylphenidate on the reproductive function of female rats

Hair Cortisol Concentration and Mental Health During Childhood and Adolescence: evidence of higher cortisol concentration in ADHD symptoms in a large Brazilian population-based birth cohort

Contact Info

Product

Resources

About