Relationship between handedness and joint involvement in rheumatoid arthritis

Yaku, Ai; Hashimoto, Motomu; Furu, Moritoshi; Ito, Hiromu; Yamakawa, Naoyuki; Yamamoto, Wataru; Fujii, Tomoyuki; Matsuda, Fumihiko; Mimori, Tsuneyo; Terao, Chikashi

doi:10.1038/srep39180

Cited by 16 publications

(9 citation statements)

References 29 publications

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“…A total of 563 RA patients were enrolled from the KURAMA (Kyoto University Rheumatoid Arthritis Management Alliance) cohort and followed up prospectively. The KURAMA cohort was established in 2011 at the Center for Rheumatic Diseases in Kyoto University Hospital for tight/proper control of RA and utilization of their sequential clinical and laboratory data for clinical investigations as described in detail previously [ 15 – 17 ]. In the current study, we enrolled all the patients consecutively from 1st May to 31st December, 2015.…”

Section: Methodsmentioning

confidence: 99%

Effect of medication adherence on disease activity among Japanese patients with rheumatoid arthritis

et al. 2018

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For the optimum efficacy of disease-modifying anti-rheumatic drugs (DMARDs), patients need to be adherent to their medication regimen. To clarify the effects of medication adherence on disease activity in Japanese patients with rheumatoid arthritis (RA), we conducted a cohort study in patients with various stages of RA. Patients were enrolled from the Kyoto University RA Management Alliance cohort, and followed up prospectively for 12 months. In this study, a total of 475 patients were analyzed and divided into 9 groups according to their medication adherence and the RA disease duration. The primary outcomes were based on the rate of a disease flare. The secondary outcomes were the changes in disease activity score using 28 joints (DAS28-ESR), simplified disease activity index (SDAI) and physical disability by health assessment questionnaire-disability index (HAQ). The changes in DAS28-ESR, HAQ, and the risk of disease flare in the highly adherent patients were significantly lower than those of the less adherent patients among the groups with RA ≤ 4.6 years but not those among the other groups. Taken together, this study identified a significant association between medication adherence and the disease flare during early-stage RA or short disease duration. These results emphasize the need to pay more attention to medication adherence in preventing the disease progression of RA.

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Section: Methodsmentioning

confidence: 99%

Effect of medication adherence on disease activity among Japanese patients with rheumatoid arthritis

et al. 2018

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“…[1][2][3][4] RA could cause joint swelling, pain, loss of function and stiffness and tremendously impact on health and quality of life of patients. [5][6][7][8] The prevalence of RA is about 3 times higher in females than males.…”

Section: Introductionmentioning

confidence: 99%

Long non‐coding RNAs in rheumatoid arthritis

Zheng

Jiang

et al. 2017

Cell Proliferation

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Rheumatoid arthritis, a disabling autoimmune disease, is associated with altered gene expression in circulating immune cells and synovial tissues. Accumulating evidence has suggested that long non-coding RNAs (lncRNAs), which modulate gene expression through multiple mechanisms, are important molecules involved in immune and inflammatory pathways. Importantly, many studies have reported that lncRNAs can be utilized as biomarkers for disease diagnosis and prognostication. Recently, dysregulation of lncRNAs in rheumatoid arthritis and other autoimmune diseases has been revealed. Experimental studies also confirmed their crosstalk with matrix metalloproteinases, nuclear factor-κB signalling and T-cell response pertinent to autoimmunity and inflammation. Circulating lncRNAs, such as HOTAIR, differentiated patients with rheumatoid arthritis from healthy subjects. Taken together, lncRNAs are good candidates as biomarkers and therapeutic targets in rheumatoid arthritis. Further investigation on in vivo delivery of these regulatory molecules and large-cohort validation of their clinical applicability may be useful.

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“…Several studies pointed out that mechanical stress such as excessive load causes trauma of the affected joints and therefore may significantly accelerate the initiation of inflammatory joint diseases . Yaku et al confirmed this thesis, as they demonstrated that handedness in terms of a higher mechanical demand plays a significant role for the increased incidence of RA in the dominant joints compared to the non‐dominant joints. Therefore, we assume that due to the higher exposure of the knee joint to mechanical stress, obvious signs of RA are more probable in the extremity joint than in the TMJ.…”

Section: Discussionmentioning

confidence: 91%

Comparative study on serum‐induced arthritis in the temporomandibular and limb joint of mice

et al. 2019

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Introduction:The subject of the present study was a systematic comparative analysis of the rheumatoid arthritis (RA)-induced pathomechanisms in the temporomandibular joint with those of the limb joints using the serum-induced arthritis K/BxN model. Methods:In 18 BALB/c mice the induction of RA was performed according to the Kouskoff method. Another healthy cohort served as controls (n = 12). Joint swelling of the paws was measured using a micrometer. Functional data were obtained analyzing locomotion. Three-dimensional examination of the temporomandibular joint was performed with micro-computed tomography imaging, followed by histological evaluation of the extremity joints and the temporomandibular joint. Additionally, immunohistochemical investigations were carried out to evaluate inflammatory and immunological changes.Results: Measurement of joint swelling showed a significant increase in the diameter of the paws, as well as a decrease in locomotor activity compared to control animals and the time before arthritis induction. Histological and immunohistochemical investigations showed clear signs of inflammation in the extremity joints. In contrast, no histological or immunohistochemical indications of an inflammatory process were detectable in the temporomandibular joint. In addition, the three-dimensional analysis by micro-computed tomography of the temporomandibular joints did not show any obvious morphological changes. Conclusion:For the first time, using the K/BxN model we could demonstrate that, due to its anatomical and mechanical conditions, the temporomandibular joint seems to be less susceptible to the initiation of RA compared to limb joints. Therefore, additional investigations are needed on other arthritis models as well, in order to further improve our understanding of the pathogenesis and defense mechanisms of the disease. K E Y W O R D SµCT, arthritis, immunhistochemistry, K/BxN, rheumatoid arthritis, temporomandibular joint

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Relationship between handedness and joint involvement in rheumatoid arthritis

Cited by 16 publications

References 29 publications

Effect of medication adherence on disease activity among Japanese patients with rheumatoid arthritis

Effect of medication adherence on disease activity among Japanese patients with rheumatoid arthritis

Long non‐coding RNAs in rheumatoid arthritis

Comparative study on serum‐induced arthritis in the temporomandibular and limb joint of mice

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