Relationship Between Handgrip Strength and Metabolic Syndrome Among Middle-Aged and Elderly Cancer Survivors

Kim, Jisu; Seo, Yeji

doi:10.1097/ncc.0000000000001018

Cited by 3 publications

(9 citation statements)

References 46 publications

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“…Of the 30 studies in 19 articles, 26 ( 12 , 14 , 15 , 17 , 37 – 50 ) were cross-sectional studies and 4 ( 50 , 51 ) were cohort studies. A total of 24 studies in 14 articles ( 12 , 14 , 17 , 38 – 43 , 47 – 51 ) originated from Asia [7 studies in 4 articles ( 14 , 42 , 43 , 50 ) from South Korea, 12 studies in 7 articles ( 12 , 38 , 39 , 47 – 49 , 51 ) from China, 4 studies in 2 articles ( 40 , 41 ) from Japan, and 1 study ( 17 ) from Singapore], 2 studies in an article ( 15 ) from the United States, 2 studies ( 37 , 44 ) from Australia, 1 study ( 46 ) from United Kingdom, and 1 study ( 45 ) from Brazil. The total sample size was 43,396 in the 30 studies (reported in 19 articles).…”

Section: Resultsmentioning

confidence: 99%

“…Jamar [3 studies ( 44 – 46 )], Takei [16 studies in 9 articles ( 14 , 15 , 17 , 40 , 42 , 43 , 47 , 48 , 50 )], Smedley [1 study ( 37 )], Camry [1 study ( 12 )], WCS-100 [4 studies in 2 articles ( 49 , 51 )], and hydraulic hand dynamometer [1 study ( 38 )] were used to measure HGS. There were 4 studies in 2 articles ( 39 , 41 ) that did not specify the name of the handgrip dynamometer.…”

Section: Resultsmentioning

confidence: 99%

“…There were 4 studies in 2 articles ( 39 , 41 ) that did not specify the name of the handgrip dynamometer. HGS measurement positions included standing [13 studies in 8 articles ( 12 , 14 , 15 , 42 , 43 , 47 , 48 , 51 )] and seated positions [4 studies ( 17 , 39 , 44 , 45 )]. A total of 13 studies in 7 studies ( 37 , 38 , 40 , 41 , 46 , 49 , 50 ) did not introduce the measurement positions of HGS.…”

Section: Resultsmentioning

confidence: 99%

“…Table 1 shows the study characteristics. Of the 30 studies in 19 articles, 26 (12,14,15,17,(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50) were cross-sectional studies and 4 (50, 51) were cohort studies. A total of 24 studies in 14 articles (12,14,17,(38)(39)(40)(41)(42)(43)(47)(48)(49)(50)(51) (38)] were used to measure HGS.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Of the 30 studies in 19 articles, 26 (12,14,15,17,(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50) were cross-sectional studies and 4 (50, 51) were cohort studies. A total of 24 studies in 14 articles (12,14,17,(38)(39)(40)(41)(42)(43)(47)(48)(49)(50)(51) (38)] were used to measure HGS. There were 4 studies in 2 articles (39, 41) that did not specify the name of the handgrip dynamometer.…”

Section: Study Characteristicsmentioning

confidence: 99%

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Association between handgrip strength and metabolic syndrome: A meta-analysis and systematic review

Wen

Liu

et al. 2022

Front. Nutr.

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BackgroundAlthough muscle strength has been reported to be associated with metabolic syndrome (MetS), the association is still controversial. Therefore, the purpose of this meta-analysis was to identify the association between handgrip strength (HGS) and MetS.MethodsOriginal research studies involving HGS and MetS from database inception to 20 May 2022 were selected from PubMed, Web of Science, Embase, China National Knowledge Infrastructure, Wanfang databases, and Chinese Biomedical Document Service System. The odds ratios (ORs) with 95% confidence intervals (CIs) of MetS for HGS were calculated using a random-effects model. A dose–response analysis was performed. Subgroup analysis and meta-regression were also conducted.ResultsThirty effect sizes (reported in 19 articles) with a total of 43,396 participants were included in this meta-analysis. All studies were considered to be of moderate-to-good quality. An inverse association between HGS (low vs. high) with MetS was shown (OR: 2.59, 95% CI: 2.06−3.25). Subgroup analyses demonstrated the pooled ORs of relative HGS (HGS/weight), relative HGS (HGS/BMI), and absolute HGS were 2.97 (95% CI: 2.37−3.71), 2.47 (95% CI: 1.08−5.63), and 1.34 (95% CI: 1.06−1.68), respectively. Dose–response analysis revealed a significant linear dose–response relationship between relative HGS (HGS/weight) and MetS in observational studies (0.1 HGS/weight: OR, 0.68; 95% CI: 0.62−0.75). Univariate meta-regression analysis indicated that country status, measuring tools of HGS, components of MetS, and diagnosed criteria of MetS explained 16.7%, 26.2%, 30.1%, and 42.3% of the tau-squared in the meta-regression, respectively.ConclusionThe results of the current meta-analysis indicated that lower HGS is associated with a higher risk of MetS. A linear dose–response association between lower relative HGS (HGS/weight) and increased prevalence of MetS was found. Accordingly, a lower HGS is a significant predictor of MetS.Systematic review registration[https://www.crd.york.ac.uk/PROSPERO/], identifier [CRD42021276730].

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

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Association between handgrip strength and metabolic syndrome: A meta-analysis and systematic review

Wen

Liu

et al. 2022

Front. Nutr.

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Understanding Heterogeneity in the Relationship Between Cancer and Hand Grip Strength: A Longitudinal Analysis

Kim

Park

2023

Res Aging

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This study examined whether the relationship between cancer and hand grip strength differs by sex and along the hand grip strength distribution. Using six waves of the Korean Longitudinal Study of Ageing (KLoSA) (N = 9735), sex-stratified unconditional quantile regression models with fixed effects were used to assess sex-specific effects of cancer for patients in different quantiles of the hand grip strength distribution. Cancer diagnosis was negatively associated with hand grip strength for males, but not females, and this sex difference was statistically significant. Quantile regression models showed that the stronger association between cancer and hand grip strength is observed among males with weaker hand grip strength. No statistically significant association was found between hand grip strength and cancer in females across the entire distribution of hand grip strength. This study provided evidence of the heterogeneity in the relationship between cancer and hand grip strength.

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Associations of Physical Activity and Handgrip Strength with Health-Related Quality of Life in Older Korean Cancer Survivors

Kim

Kang

Kim

et al. 2022

Cancers

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Background: Uncertainty exists regarding the associations between physical activity (PA), relative handgrip strength (RHGS), and health-related quality of life (HRQoL) among elderly Korean cancer survivors. This study investigated the moderating effect of RHGS on the relationship between PA and HRQoL in 308 cancer survivors aged ≥65 years using the data from the Korean National Health and Nutrition Examination Survey in 2014–2019. Methods: HRQoL was evaluated with the EuroQol-5-dimension instrument. PA and handgrip strength were assessed with the Global Physical Activity Questionnaire and a hand dynamometer, respectively. Age, sex, body mass index, income, marital status, educational background, heavy alcohol consumption, smoking status, multimorbidity, and hemoglobin were included as covariates. Results: Bivariate logistic regression showed that insufficient PA and no PA were associated with higher odds of a low HRQoL (odds ratio, OR = 2.6, 95% confidence interval, CI = 1.3~5.1, p = 0.005; OR = 2.4, 95% CI = 1.1~5.0, p = 0.024, respectively), compared with sufficient PA (OR = 1). Weak RHGS was associated with high odds of a low HRQoL (OR = 2.6, 95%= 1.530~4.6, p < 0.001) compared with normal RHGS (OR = 1). Particularly, RHGS (β = −0.0573, 95% CI = −0.1033~−0.0112) had a significant moderating effect on the relationship between PA and HRQoL even after adjustments for all the covariates. The negative influence of physical inactivity on HRQoL was observed in cancer survivors with weak RHGS but not in cancer survivors with normal RHGS. Conclusions: The current findings suggest that maintaining or promoting muscular strength through regular exercise is critical for the HRQoL of elderly Korean cancer survivors.

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Relationship Between Handgrip Strength and Metabolic Syndrome Among Middle-Aged and Elderly Cancer Survivors

Cited by 3 publications

References 46 publications

Association between handgrip strength and metabolic syndrome: A meta-analysis and systematic review

Association between handgrip strength and metabolic syndrome: A meta-analysis and systematic review

Understanding Heterogeneity in the Relationship Between Cancer and Hand Grip Strength: A Longitudinal Analysis

Associations of Physical Activity and Handgrip Strength with Health-Related Quality of Life in Older Korean Cancer Survivors

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