Relationship between helminthic infection and IgE response in atopic and nonatopic children in a tropical environment☆☆☆★★★

Lynch, Neil R.; Hagel, Isabel; Palenque, Miguel; Prisco, María Cristina Di; Escudero, Jaime E.; Corao, L.Alejandra; Sandia, J.Alberto; Ferreira, Lisbeth J.; Botto, Carlos; Pérez, Mireya

doi:10.1016/s0091-6749(98)70386-0

Cited by 166 publications

(183 citation statements)

References 34 publications

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“…As regards IgE, previous studies have described that synthesis of this immunoglobulin is an important component of immune resistance against helminthic infections (61,62). High serum IgE in individuals with AIDS were seen at the beginning of the epidemic and confirmed years later by other studies (63)(64)(65)(66)(67)(68)(69).…”

Section: Discussionmentioning

confidence: 63%

Intestinal parasitic infections in HIV/AIDS patients: epidemiological, nutritional and immunological aspects

Amâncio¹,

Pascotto²,

Souza³

et al. 2012

J. Venom. Anim. Toxins incl. Trop. Dis

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This study applied a socioeconomic questionnaire designed to evaluate the frequency of intestinal parasites and characterize epidemiological, nutritional, and immunological variables in 105 HIV/AIDS patients -with and without parasitic infections, attending the Day Hospital in Botucatu, UNESP, from 2007 to 2008. Body mass index was calculated and the following tests performed: parasitological stool examinations; eosinophil, IgE, CD4 + T and CD8 + T lymphocyte cell counts; albumin test; viral load measure; and TNF-α, IFN-γ, IL-2, IL-5 and IL-10 cytokine levels. Results were positive for parasitic intestinal infections in 12.4% of individuals. Most patients had good socioeconomic conditions with basic sanitation, urban dwellings, treated water supply and sewage, good nutritional and immunological status and were undergoing HAART. Parasites were found at the following frequencies: Entamoeba -five patients (38.5%), Giardia lamblia -four (30.7%), Blastocystis hominis -three (23.0%), Endolimax nana -two (15.4%), and Ascaris lumbricoides -one (7.7%). There were no significant differences between the two groups for eosinophils, albumin, IgE, CD4 + T and CD8 + T lymphocytes, INF-γ, IL-2, or IL-10. Most patients also showed undetectable viral load levels. Significant differences were found for TNF-α and IL-5. These results show the importance of new studies on immunodeficient individuals to increase understanding of such variables.

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Section: Discussionmentioning

confidence: 63%

Intestinal parasitic infections in HIV/AIDS patients: epidemiological, nutritional and immunological aspects

Amâncio¹,

Pascotto²,

Souza³

et al. 2012

J. Venom. Anim. Toxins incl. Trop. Dis

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“…Como na área de estudo são observadas altas prevalên-cias de enteroparasitoses 10 e todas as crianças apresentam calendário vacinal completo, seria de se esperar a diminuição de doenças alérgicas e que a ocorrência de fatores imunoprotetores TH1 fosse desencadeada, funcionando como mecanismo para a menor ocorrência de DA 14,27 .…”

Section: Discussionunclassified

“…Outros estudos, como de o Lynch et al 14 15 , observaram redução do risco de sensibilização aos aeroalérgenos nas crianças com infecção pelo A. lumbricoides. Em estudo anterior, na comunidade do Pedregal, Campina Grande, não foi observada a associação entre asma e ascaridíase 14 . Leonardi-Bee et al 16 , em uma meta-análise, associaram a infecção por A. lumbricoides a um significante aumento do risco de asma.…”

Section: Introductionunclassified

Atopic dermatitis and ascariasis in children aged 2 to 10 years

et al. 2010

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Objective: To assess the association between atopic dermatitis (AD) and ascariasis in 2 to 10-aged children from the neighborhood Pedregal, in the city of Campina Grande, Brazil, an area of low socioeconomic index. Methods:Cross-sectional study conducted with the use of the standard questionnaire from the International Study of Asthma and Allergies in Childhood (ISAAC) and stool parasitological exam for Ascaris lumbricoides. The dependent variable was AD diagnosis: absent, mild, and severe. Multivariate logistic regression and descriptive analysis of the variable were used. Associations were estimated using relative risk (RR) and odds ratio (OR). The statistical inference was based on 95% confidence intervals (95%CI). Results:We assessed 1,195 children, 612 (51.2%) female. The AD prevalence was 24.6%, and ascariasis prevalence was 26.1%. In the mild AD group of children, 44 (36.7%) were infected by A. lumbricoides, while in the severe AD group, 40 (22.9%) had the same geohelminthosis (p = 0.01). Comparing negative cases of AD between mild and severe forms, the infection with A. lumbricoides increased the frequency of mild AD (RR = 1.7; p = 0.009), but not the severe form (RR = 0.86; p = 0.46). Evaluating only the positive cases of dermatitis, 120 mild AD (40.8%) and 176 with severe AD (58.2%), it can be said that the exposure to the parasite decreased the frequency of the severe form of dermatitis (RR = 1.46; p = 0.016). Conclusion:There is a high prevalence of AD and of ascariasis in the population studied. The severe AD is related to lower parasitemia of A. lumbricoides. J Pediatr (Rio J). 2010;86(1):53-58: Atopic dermatitis, ascariasis, prevalence, children. ResumoObjetivo: Avaliar a associação entre dermatite atópica (DA) e ascaridíase em crianças de 2 a 10 anos do bairro do Pedregal, Campina Grande (PB), área de baixos indicadores socioeconômicos.Métodos: Trata-se de estudo transversal a partir da aplicação do questionário padrão do International Study of Asthma and Allergies in Chlidhood (ISAAC) e exame parasitológico de fezes para Ascaris lumbricoides. A variável dependente foi o diagnóstico de DA ausente, DA leve e DA grave. Efetuou-se análise de regressão logística multivariada, bem como análise descritiva das variáveis do estudo. As associações foram estimadas por meio de risco relativo (RR) e razão de chances (odds ratio, OR). A inferência estatística foi baseada em intervalos de confiança de 95% (IC95%). Resultados:Foram avaliadas 1.195 crianças, sendo 51,2% (n = 612) do sexo feminino. A prevalência de DA foi de 24,6%, e a de ascaridíase, de 26,1%. Das crianças com DA leve, 44 (36,7%) eram parasitadas pelo A. lumbricoides, enquanto que 40 (22,9%), com DA grave, apresentavam a mesma geo-helmintose (p = 0,01). Comparando-se os casos negativos para DA com os casos leves e graves, constatou-se que a presença de ascaridíase aumentou a ocorrência de dermatite leve (RR = 1,7; p = 0,009), mas não de DA grave (RR = 0,86; p = 0,46). Avaliando-se apenas os casos positivos de dermatite, DA leve (n = 120;...

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“…Studies performed by Lynch and collaborators have both demonstrated that people living in an endemic area for Ascaris lumbricoides have a decreased reactivity to the immediate hypersensitivity skin prick tests, and that treatment with anti-helminthic drugs resulted in increased frequency of positive skin prick tests and aeroallergen-specific IgE production (Lynch et al 1993(Lynch et al , 1998. Supporting this idea, we evaluated whether immediate hypersensitivity reaction and aeroallergen specific IgE levels are influenced by the presence of S. mansoni, taking into account the potential influences of age and gender on this association.…”

Section: Influence Of Parasite Infection On the Devel-opment Of Allermentioning

confidence: 99%

Schistosoma mansoni infection modulates the immune response against allergic and auto-immune diseases

Araújo

Hoppe

Medeiros

et al. 2004

Mem. Inst. Oswaldo Cruz

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Relationship between helminthic infection and IgE response in atopic and nonatopic children in a tropical environment☆☆☆★★★

Cited by 166 publications

References 34 publications

Intestinal parasitic infections in HIV/AIDS patients: epidemiological, nutritional and immunological aspects

Intestinal parasitic infections in HIV/AIDS patients: epidemiological, nutritional and immunological aspects

Atopic dermatitis and ascariasis in children aged 2 to 10 years

Schistosoma mansoni infection modulates the immune response against allergic and auto-immune diseases

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