Relationship between hemodynamic alteration and sympathetic nerve activation following a single oral dose of cinnamtannin A2

Koizumi, Ryo; Fushimi, Taiki; Sato, Yuki; Fujii, Yasuyuki; Sato, Hiroki; Osakabe, Naomi

doi:10.1080/10715762.2020.1759805

Cited by 7 publications

(11 citation statements)

References 38 publications

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“…A single high dose of cocoa flavanol alone elicited no change in BP, but BP increased markedly and transiently by co-administered with yohimbine. Similar results were observed co-administration of B-type procyanidin tetramer A2 (100 μg/kg) and yohimbine ( 80 ).…”

Section: Introductionsupporting

confidence: 82%

“…We also compared B-type procyanidins such as the monomer [(-)-epicatechin; EC], dimer (procyanidin B2; B2), trimer (procyanidin C1; C1), and tetramer (cinnamtannin A2; A2) on hemodynamics ( 80 ). At a dose of 10 μg/kg, A2 and B2 were associated with a marked increase in cremasteric arteriole blood flow, C1 was linked to a slight increase, and EC did not trigger any change.…”

Section: Introductionmentioning

confidence: 99%

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Hormetic response to B-type procyanidin ingestion involves stress-related neuromodulation via the gut-brain axis: Preclinical and clinical observations

2022

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B-type procyanidins, a series of catechin oligomers, are among the most ingested polyphenols in the human diet. Results of meta-analyses have suggested that intake of B-type procyanidins reduces cardiovascular disease risk. Another recent focus has been on the effects of B-type procyanidins on central nervous system (CNS) function. Although long-term B-type procyanidin ingestion is linked to health benefits, a single oral intake has been reported to cause physiological alterations in circulation, metabolism, and the CNS. Comprehensive analyses of previous reports indicate an optimal mid-range dose for the hemodynamic effects of B-type procyanidins, with null responses at lower or higher doses, suggesting hormesis. Indeed, polyphenols, including B-type procyanidins, elicit hormetic responses in vitro, but animal and clinical studies are limited. Hormesis of hemodynamic and metabolic responses to B-type procyanidins was recently confirmed in animal studies, however, and our work has linked these effects to the CNS. Here, we evaluate the hormetic response elicited by B-type procyanidins, recontextualizing the results of intervention trials. In addition, we discuss the possibility that this hormetic response to B-type procyanidins arises via CNS neurotransmitter receptors. We have verified the direction of future research for B-type procyanidins in this review.

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Section: Introductionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Hormetic response to B-type procyanidin ingestion involves stress-related neuromodulation via the gut-brain axis: Preclinical and clinical observations

2022

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“…In previous studies, A2 exhibited potent bioactivity showing increased peripheral blood flow and thermogenic alteration for brown adipose. ( 10 , 12 ) We also found that these changes were reduced by co-treatment with adrenaline blockers. While the activation of SNS induced by exercise, cold exposure, or ingestion of spice is well known to alter hemodynamics and metabolism through CAs secreted for organs or blood.…”

Section: Discussionsupporting

confidence: 57%

“…( 7 – 9 ) The epicatechin tetramer cinnamtannin A2 (A2) has been described as a powerful bioactive compound promoting thermogenesis, ( 10 ) glucagon-like peptide-1, ( 11 ) and a marked increase in skeletal muscle blood flow. ( 12 )…”

Section: Introductionmentioning

confidence: 99%

Cinnamtannin A2, (−)-epicatechin tetramer, attenuates skeletal muscle wasting in disuse atrophy model mice induced by hindlimb suspension

Muta

Oyama

Odaka

et al. 2023

J. Clin. Biochem. Nutr.

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The impact of repeated administration of cinntamtannin A2 (A2, 25 μg/kg) on skeletal muscle disuse atrophy model mice induced by hindlimb suspension for 14 days was examined. In soleus, weight loss and a reduction in the average myofibre size with shifting to the smaller side of the peak were observed in the suspension-vehicle group, but A2 reduced these changes. Average myofibre size significantly increased in ground-A2 compared to ground-vehicle. A marked increase in the dephosphorylation of forkhead box O (FoxO) 3a by the suspension was reduced by A2. The phosphorylation of protein kinase B (Akt) and eukaryotic translation initiation factor 4E-binding protein (4EBP)-1 were significantly increased by the treatment of A2. In addition, a single dose of A2 increased dramatically in the 24-h excretion of catecholamines in urine. These results suggest that A2 administration results in sympathetic nerve activation and promotes hypertrophy while inhibiting the progress of disuse muscle atrophy.

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“…Thus, several experiments were conducted using adrenergic receptor inhibitors to investigate the relationship between these effects and the sympathetic nervous system. According to the results, it was suggested that the rapid changes in hemodynamics after a single dose of flavanols were mediated by adrenergic receptors, i.e., sympathetic hyperactivation [112,115]. Furthermore, it has been suggested that the hemodynamic absence seen with high doses of flavanols compared to low doses was due to the activation of α2 receptors, an autoreceptor expressed in CNS [112,115].…”

Section: Astringency Perception Is a Stressormentioning

confidence: 99%

Sensory Nutrition and Bitterness and Astringency of Polyphenols

Osakabe,

Shimizu,

Fujii

et al. 2024

Biomolecules

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Recent studies have demonstrated that the interaction of dietary constituents with taste and olfactory receptors and nociceptors expressed in the oral cavity, nasal cavity and gastrointestinal tract regulate homeostasis through activation of the neuroendocrine system. Polyphenols, of which 8000 have been identified to date, represent the greatest diversity of secondary metabolites in plants, most of which are bitter and some of them astringent. Epidemiological studies have shown that polyphenol intake contributes to maintaining and improving cardiovascular, cognitive and sensory health. However, because polyphenols have very low bioavailability, the mechanisms of their beneficial effects are unknown. In this review, we focused on the taste of polyphenols from the perspective of sensory nutrition, summarized the results of previous studies on their relationship with bioregulation and discussed their future potential.

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Relationship between hemodynamic alteration and sympathetic nerve activation following a single oral dose of cinnamtannin A2

Cited by 7 publications

References 38 publications

Hormetic response to B-type procyanidin ingestion involves stress-related neuromodulation via the gut-brain axis: Preclinical and clinical observations

Hormetic response to B-type procyanidin ingestion involves stress-related neuromodulation via the gut-brain axis: Preclinical and clinical observations

Cinnamtannin A2, (−)-epicatechin tetramer, attenuates skeletal muscle wasting in disuse atrophy model mice induced by hindlimb suspension

Sensory Nutrition and Bitterness and Astringency of Polyphenols

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