Relationship between Hepcidin, Ferritin and C-Reactive Protein in Hemodialysis Patients

Elmenyawi, Azza A I.; Hassan, Ahmed; Said, Seham A.

doi:10.12816/0040604

Cited by 7 publications

(7 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5,6 Most of the study subjects were men with a percentage of 67.5%, similar to studies by Toima, et al, Mercadel, et al, Elmenyawi, et al 5,6,7 Higher male prevalence than female could be infl uenced by numerous factors like hypertension, hyperglycemia, lifestyle, kidney structure and hormonal diff erences. 8 The mean age in this study was 50.23 ± 1.04 years old, similar to studies by Mercadel, et al, Toima, et al, 2010, Elmenyawi, et al 5,6,7 Aging process infl uenced CKD progression and lesser function was expected from older nephrons. 9 Mean hemoglobin result in this study was 10.74 g/dL with SE of 0.36.…”

Section: Discussionsupporting

confidence: 82%

“…In a study by Elmenyawi et al the most frequent CKD stage in the population was stage 3 with mean CRP level at 3.52 and 4.28 mg/L. 7 In the study of Toima et al and Rasheed et al the highest staging in the population was stage 5 and mean CRP levels were, 6.0 and 7.59 mg/L. 5,13 This study found that CRP level increased along with a decrease in eGFR, which were consistent with other studies.…”

Section: Discussionmentioning

confidence: 94%

“…This was similar to previous studies by Toima et al who found CRP levels of 6.0 mg/L with a standard deviation of 0.9, Elmenyawi et al who found mean CRP level was 4.28 mg/L with a standard deviation of 3.7, Rasheed et al who found CRP mean levels were 7.59 mg/L in all CKD stages, and. 5,7,13 Fluctuations in CRP levels may also have been due to the highest staging diff erences in the population study. In a study by Elmenyawi et al the most frequent CKD stage in the population was stage 3 with mean CRP level at 3.52 and 4.28 mg/L.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

C-reactive Protein and Hepcidin in Non-Dialysis Chronic Kidney Disease

Putera

Widodo

Mardiana

2020

IJTID

View full text Add to dashboard Cite

Complications such as anemia and its clinical consequences arise as chronic kidney diseases progress,. One renal anemia pathophysiology is a disruption of iron metabolism, regulated by the main iron exporter hormone, hepcidin. Chronic kidney disease patients were constantly in an inflammatory state, represented by an increased in C-reactive protein. This inflammatory state would facilitate the liver to secrete hepcidin, which would subsequently follow a decrease of iron circulation, thus resulting in functional iron deficiency. Both acute phase reactants which used thoroughly as markers in tropical and infectious diseases, had their own roles in chronic kidney disease. The correlation of c-reactive protein and hepcidin in chronic kidney disease patients was still controversial. To analyse the relationship between c-reactive protein and hepcidin in non-dialysis chronic kidney disease patients. We conducted an observational cross-sectional study with 40 non-dialysis chronic kidney disease patients who met the inclusion and exclusion criteria. Patients were enrolled with consecutive sampling and were examined for serum c-reactive protein and hepcidin levels.A total of forty subjects (67.5% male with mean age of 50.23 ± 1.04 years) were eligible for enrolment in this study. The most comorbid factor was hypertension (62.5%). The common stage for chronic kidney disease was stage 3 (40%). The mean hemoglobin value was 10.74 ± 0.36 g/dL, mean blood urea nitrogen was 39.98 ± 29.59 mg/dL, and serum creatinine of 4.12 ± 3.39 mg/dL. Mean serum c-reactive protein levels were 3.52 ± 5.13 mg/l. Mean hepcidin level were 94,03 ± 95,39 ng/ml. Serum C-reactive protein levels correlated positively (r=0.487) and significantly (p-value=0.001) with serum hepcidin value. C-reactive protein and hepcidin was significantly correlated in non-dialysis chronic kidney disease patients.

show abstract

Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

C-reactive Protein and Hepcidin in Non-Dialysis Chronic Kidney Disease

Putera

Widodo

Mardiana

2020

IJTID

View full text Add to dashboard Cite

show abstract

“…This may be explained by the higher sample size than our study and that one of those studies (12) was done on haemodialysis patients with chronic hepatitis C virus. Otherwise, an insignificant positive weak correlation between serum levels of hepcidin and ferritin (15).…”

Section: Resultsmentioning

confidence: 96%

Study of serum hepcidin level and its relation to recombinant human erythropoietin resistence, markers of iron status and C-reactive protein in patients with end stage renal disease on maintenance hemodialysis.

Elbadawy

Ibraheim

Khalil

et al. 2021

Benha Medical Journal

View full text Add to dashboard Cite

Background: Anemia represents a significant problem to deal with in patients with chronic kidney disease (CKD) on haemodialysis (HD). This work aimed to determine the usefulness of measuring serum hepcidin level in patients with end stage renal disease (ESRD) on maintenance hemodialysis and anemia, and assess the possible correlation between serum hepcidin level and markers of iron status (serum iron, serum ferritin, total iron binding capacity and iron saturation), erythropoietin resistance and inflammatory markers (C-reactive protein). Methods: The study was performed on (50 patients) with end stage renal disease on maintenance haemodialysis. Patients were divided into two groups: group (I): 40 patients who have anaemia responsive to erythropoietin therapy and group (II): 10 patients who have anaemia resistant to erythropoietin therapy. All patients were subjected to thorough history taking, clinical examination, and laboratory investigations. Results: serum hepcidin level was higher in all patients with erythropoietin resistance index (ERI) < 15 compared to patients with ERI > 15. There was a highly significant positive correlation between serum hepcidin level and ERI and significant negative correlation between serum hepcidin level and serum iron, ferritin and transferrin saturation. But no significant correlation between serum hepcidin level and C-reactive protein. Conclusion: Hepcidin is associated with anemia, markers of iron status and erythropoietin resistance. If used as a diagnostic tool, it might improve iron therapy in patients with functional iron deficiency due to reticuloendothelial blockage of iron transport. This is important to avoid iron overload and to improve erythropoietin (EPO) response in patients with ESRD.

show abstract

“…This could be attributed to the risk of inflammatory and infection processes during dialysis. However, patients with RRT were excluded from the current study [44].…”

Section: Resultsmentioning

confidence: 99%

Evaluation of YKL-40 as a Biomarker of Inflammation and Atherosclerosis in Chronic Kidney Disease Patients

El-Ghorab

Elshafey²,

Negm³

et al. 2022

JAMMR

View full text Add to dashboard Cite

Background: Chronic kidney disease (CKD) has been recognized as a leading public health problem worldwide. In Egypt, CKD approximately affects 13% of the adult population, resulting in significant morbidity, mortality, and health care costs. Patients with advanced CKD (stage 3 or more) experience a high rate of cardiovascular complications compared to earlier stages of CKD. Objective: To evaluate serum YKL-40 levels in patients with CKD to assess its value as a biomarker of inflammation and its correlation with carotid intima-media thickness (CIMT) as a predictor for early atherosclerosis. Patients and Methods: The present study was conducted on fifty subjects divided into 2 groups: group I includes 25 patients with CKD (from stage 1 to stage 5 "pre-dialysis") and group II (control group) includes 25 healthy volunteers. The patients were recruited from Internal Medicine Department and Nephrology Unit, Tanta university hospitals in the period between," August 2020 to September 2021 ". Results: In our study, YKL-40 levels were significantly high in CKD patients(P=0.001). As regards CIMT measurements for the studied cases its median value was 0.90 and1 mm for the right and left carotid respectively. On the other hand, CIMT measurements for the studied volunteers were within the normal range with statistically significant differences between both groups (p=0.001). There is a positive significant correlation between the serum YKL-40 level from the studied cases with each of triglycerides, serum urea, serum creatinine, CRP, ESR, R CIMT, and L CIMT. Systolic blood pressure, triglyceride, cholesterol, LDL, serum urea, serum creatine, e-GFR, ESR, CRP, and YKL-40 were found to be independent predictors for CIMT (P<0.05). Serum YKL-40 is a highly sensitive predictor of atherosclerosis in CKD and its specificity is 74% in CKD cases. Conclusion: Serum YKL-40 was significantly high in CKD patients. YKL-40 could be used as a biomarker for inflammation and early detection of atherosclerosis in patients with CKD, but further studies are needed. YKL-40 is an independent predictor of increased CIMT and early atherosclerosis. YKL-40 is highly sensitive to increased CIMT.

show abstract

Relationship between Hepcidin, Ferritin and C-Reactive Protein in Hemodialysis Patients

Cited by 7 publications

References 32 publications

C-reactive Protein and Hepcidin in Non-Dialysis Chronic Kidney Disease

C-reactive Protein and Hepcidin in Non-Dialysis Chronic Kidney Disease

Study of serum hepcidin level and its relation to recombinant human erythropoietin resistence, markers of iron status and C-reactive protein in patients with end stage renal disease on maintenance hemodialysis.

Evaluation of YKL-40 as a Biomarker of Inflammation and Atherosclerosis in Chronic Kidney Disease Patients

Contact Info

Product

Resources

About