Relationship between high CRP and cytokines in Saudi old people with dental caries in alkharj Region, Saudi Arabia

Alanazi, Arwa F.; Alenezy, Awwad; Alotiby, Amna; Bukhari, Talat; Alturaiki, Wael; Binshaya, Abdulkarim S.; Waggiallah, Hisham Ali; W, Harbi; Kahtani, Y; Majli, K; Alanazi, Amani F.; Alenzi, Faris Q.

doi:10.1016/j.sjbs.2021.03.022

Cited by 4 publications

(3 citation statements)

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“…In addition, the present study revealed that dental caries after complete treatment (filled teeth) were no longer associated with myopia. Active dental caries are caused by poor oral hygiene and bacterial growth in the teeth [27], which can lead to dental destruction and systemic inflammation [11]. If the actively dental caries were treated, the impact of systemic inflammation on lens fibrosis would be much reduced [28], thus decreasing the risk of myopia [29].…”

Section: Discussionmentioning

confidence: 99%

“…Several risk factors, such as low physical activity and body weight, may lead to both dental caries and high myopia [6][7][8][9]. In addition, systemic inflammation related to periodontitis [10] and actively dental caries [11] may play a role in the process of various ocular diseases. In the 1970s, Goldstein et al [12] and Hirsh et al [13] reported that there was a higher risk of dental caries in myopic children than in nonmyopic children.…”

Section: Introductionmentioning

confidence: 99%

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Dental caries and periodontitis and the risk of myopia in young adults: CHIEF oral health study

et al. 2022

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Aim Oral health and ocular diseases may be associated with collagen defects and inflammation status. However, the results from prior studies are conflicting. The aim of this study was to explore the association of dental caries and periodontitis with myopia in young adults. Materials and methods A total of 938 military personnel aged 19–39 years receiving both oral and eye examinations from 2018 through 2020 were included in this study in Taiwan. The severity of myopia was graded as no myopia (diopters > − 0.5, N = 459), low myopia (diopters: − 0.5 to -5.9, N = 225) and high myopia (diopters ≤ − 6.0, N = 254). A multiple logistic regression analysis with adjustments for age, body mass index, systolic blood pressure, smoking, alcohol consumption, missing teeth numbers, blood leucocyte counts, triglycerides, high-density lipoprotein, and uric acid were used to determine the associations of actively dental caries, filled teeth and stage II/III periodontitis with myopia. Results The presence of any actively dental caries was significantly associated with a higher risk of any myopia (low or high) (odds ratio [OR] and 95% confidence intervals [95% CI] 1.42 [1.04–1.94]), whereas there was no association for filled teeth. Moreover, the association for stage II/III periodontitis was only observed with high myopia (OR: 1.52 [1.07–2.15]) and was not observed with low myopia. Conclusions Our findings suggest that only actively dental caries and a higher severity of periodontitis were associated with myopia among young adults, thus highlighting the dental inflammation status in the oral cavity as a potential link to ocular diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dental caries and periodontitis and the risk of myopia in young adults: CHIEF oral health study

et al. 2022

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“…Dental caries, characterized by non-communicable, net-mineral loss of dental hard tissues, results from acid production by cariogenic bacteria fermenting free sugars ( 16 – 18 ). This oral health condition fueled by fermentable sugars, initiate a cascade of inflammatory responses within the oral cavity which results in increased production of an acute-phase protein known as C-reactive protein (CRP) ( 19 ). Increased CRP level is considered as a risk factor for developing cardiovascular diseases ( 20 , 21 ) and hypertension ( 20 , 22 ).…”

Section: Introductionmentioning

confidence: 99%

Can oral health care be a gateway to improve cardiovascular disease? A scoping review

Usmani,

de Courten,

Hanna

2024

Front. Oral. Health

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BackgroundCardiovascular diseases (CVDs) are a significant cause of morbidity and mortality worldwide, resulting in a high socioeconomic burden. Growing evidence has shown a link between oral diseases and several chronic conditions including CVDs. The focus of this review is to investigate and summaries the evidence surrounding oral health interventions and their potential impact on reducing both the risk and/or severity of CVDs.MethodsA scoping review was conducted to examine oral health interventions for managing CVD outcomes and risks. The review adhered to the Joanna Briggs Institute (JBI) framework for evidence synthesis and followed the reporting standards outlined by the Preferred Reporting Items for Systematic Reviews and Meta-analysis- extension to Scoping Review (PRISMA-ScR). A systematic search across EBSCOhost, PubMed, and Scopus databases from 2012 to 2024 was utilized to identify relevant studies. Inclusion criteria focused on English language articles with a sample size of at least 50, evaluating the impact of oral health interventions on CVD outcomes.ResultsOut of the initial 2,154 studies identified in the search, 12 studies met the inclusion and exclusion criteria and were included in the final analysis. Overall, the studies revealed that along with surgical and non-surgical periodontal therapy, regular oral hygiene care practices, including toothbrushing, tongue brushing, and flossing, significantly reduced the risk of cardiovascular events and mortality. These interventions in patients with or without CVD baseline have shown a decrease in CVD risk markers as well as a reduction in bacterial colonization. Similarly, consistent oral hygiene routines, combined with regular dental visits, were associated with a lower risk of heart failure and CVD risk mortality.ConclusionThe evidence extracted from this review suggests that periodontal therapy, regular dental cleaning, and re-enforcing of oral health regimes can stabilize oral health conditions and subsequently improve CVD progression/risks. However, limited to no evidence exists regarding the therapeutic effects of oral health promotion in managing CVD markers and its direct impact on disease outcomes, warranting further investigation.

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The association between dental caries and serum crp in the us adult population: evidence from NHANES 2015–2018

AlShammari,

AlSaleh,

AlKandari

et al. 2024

BMC Public Health

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Background Dental caries remains one of the most prevalent diseases worldwide, affecting 29.4% of the global population. Despite numerous efforts to diagnose, predict, and prevent dental caries, the incidence continues to rise. Salivary biomarkers provide a non-invasive means for early detection of various oral conditions. C-reactive protein (CRP) is a key marker, elevated in both oral and general inflammatory conditions such as diabetes, periodontitis and oral squamous cell carcinoma. Considering the emerging connection between oral and systemic health, it is worth exploring the various factors associated with this widespread disease. This study investigates the association between CRP levels and dental caries in the United States population, utilizing data from the National Health and Nutrition Examination Survey (NHANES). Methods The study analyzed data from the 2015–2018 NHANES cycles, focusing on a nationally representative sample of individuals aged 30 years and above. Weighted multivariable negative binomial and logistic regression analyses were employed to explore the relationship between dental caries and CRP levels, adjusting for age, gender, race, education level, diabetes status, and gum disease. Results The results of the negative binomial regression analysis demonstrated a positive association between higher CRP levels and an increased mean number of dental caries (Adjusted Mean Ratio [AMR] = 1.7; 95% CI: 1.3 – 2; P: < 0.001). The logistic regression analysis showed that individuals with higher CRP levels have a 50% increase in the odds of developing dental caries (AOR: 1.5, CI: 1.2 – 1.9; P: < 0.01). Conclusion The results of this cross-sectional study of the U.S. population highlight the positive association between high CRP levels and increased dental caries. These findings contribute to the growing body of evidence supporting the integration of oral and systemic health care. Further research is necessary to deepen our understanding of the mechanistic relationship between CRP levels and dental caries.

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Relationship between high CRP and cytokines in Saudi old people with dental caries in alkharj Region, Saudi Arabia

Cited by 4 publications

References 20 publications

Dental caries and periodontitis and the risk of myopia in young adults: CHIEF oral health study

Dental caries and periodontitis and the risk of myopia in young adults: CHIEF oral health study

Can oral health care be a gateway to improve cardiovascular disease? A scoping review

The association between dental caries and serum crp in the us adult population: evidence from NHANES 2015–2018

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