Relationship between HPLC precision and number of significant figures when reporting impurities and when setting specifications

Analytical Method Validation for Biopharmaceuticals

“…Agut et al (Agut, Segalini et al 2006) examined different rules and their application to the reporting interval of results and specifications. The best known and simplest rule to implement is that stated in the AMST standard E-29-02.…”