Relationship between Hypothyroidism and Endometrial Cancer

Wang, Yiqin; Zhou, Rong; Wang, Jianliu

doi:10.14336/ad.2018.0224

Cited by 24 publications

(26 citation statements)

References 52 publications

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“…Several studies have shown that hypothyroidism is closely related to MS, PCOS, elevated serum leptin levels, and dyslipidemia. Hypothyroidism may promote the occurrence and development of endometrial cancer by indirectly increasing the risk factors of endometrial cancer or through direct interaction (123). Studies examining the relationship between thyroid function (TSH level) and endometrial cancer will provide new insights into the mechanism of endometrial cancer.…”

Section: Other Types Of Diseases Of Metabolic Syndrome and Endometriamentioning

confidence: 99%

The Role of Metabolic Syndrome in Endometrial Cancer: A Review

2019

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Endometrial cancer is one of the most common cancers of the female reproductive system. Although surgery, radiotherapy, chemotherapy, and hormone therapy can significantly improve the survival of patients, the treatment of patients with very early lesions and a strong desire to retain reproductive function or late recurrence is still in the early stages. Metabolic syndrome (MS) is a clustering of at least three of the five following medical conditions: central obesity, high blood pressure, high blood sugar, high serum triglycerides, and low serum high-density lipoprotein (HDL). Obesity, diabetes and hypertension often coexist in patients with endometrial cancer, which increases the risk of endometrial cancer, also known as the “triple syndrome of endometrial cancer.” In recent years, epidemiological and clinical studies have found that MS associated with metabolic diseases is closely related to the incidence of endometrial cancer. However, the key molecular mechanisms underlying the induction of endometrial cancer by MS have not been elucidated to date. Characterizing the tumor metabolism microenvironment will be advantageous for achieving a comprehensive view of the molecular mechanism of metabolic syndrome associated with endometrial cancer and for providing a new target for the treatment of endometrial cancer. This review focuses on recent advances in determining the role of metabolic syndrome-related factors and mechanisms in the pathogenesis of endometrial cancer. We suggest that interfering with the tumor metabolic microenvironment-related molecular signals may inhibit the occurrence of endometrial cancer.

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Section: Other Types Of Diseases Of Metabolic Syndrome and Endometriamentioning

confidence: 99%

The Role of Metabolic Syndrome in Endometrial Cancer: A Review

2019

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“…In recent times, a strong association between primary malignancies of thyroid and melanoma has been established [ 116 ]. At the same time increased TSH level is associated with poor prognosis for endometrial carcinoma patients [ 117 ]. A meta-analysis study reported an elevated risk of colorectal cancer in patients with hypothyroidism and thyroid replacement therapy has a protective role [ 118 ].…”

Section: Disorders and Diseases Associated With Thyroid Dysfunctionmentioning

confidence: 99%

Prospective role of thyroid disorders in monitoring COVID-19 pandemic

Kumari

Chainy

Subudhi

2020

Heliyon

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“…All these factors were evident in the best “four-factor” model for the primary female infertility ( Supplementary Note ). The influence of elevated TSH and LH/FSH ratio may also lead to the formation of myometrial and endometrial hyperplasia in forms of polyp/tumour [44,45], which cause infertility in females by bleeding, blocking or obliterating the passage of sperm conduction [46,47]. Besides, collection of fluid in the POD is generally associated with infection [48,49], rupture of cyst [50], and ectopic pregnancy [51], contributing to female infertility, and so, these two radiologically diagnosed factors were identified as significant risk factors for female infertility in this study.…”

Section: Discussionmentioning

confidence: 99%

Down-regulatedGDF9andBMP15mRNAs are the important determining factors for the unexplained female infertility cases advised for assisted reproductive technology

Gupta

Kundu

Dhar

et al. 2019

Preprint

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Down-regulated GDF9 and BMP15 mRNAs are the important 2 determining factors for the unexplained female infertility cases 3 advised for assisted reproductive technology 4 5 Down-regulation of GDF9 and BMP15 mRNAs in unexplained female infertility 31 32 2 33 Abstract 34Background: In India, the potential risk factors influencing female infertility are not well-characterized. 35 Hence, this study was initially aimed to determine the multi-factor risk-predictive models for the infertile 36 females from different Indian ethnics. Afterwards, when treatment was performed for correcting the abnormal 37 demographic and clinical parameters obtained from our initial findings, some of the patients were observed to 38 be treatment-non-responsive. This further recommended assessing the expression pattern of GDF9 and 39 BMP15 mRNAs in those unexplained infertile females. 40 Methodology: This study included 470 Primary, 209 Secondary infertile and 419 age-matched Healthy 41 females, where baseline demographic and clinicopathological factors were assessed. Additionally, from the 42 treatment-non-responsive patients, laparoscopy and trans-vaginal ultrasound-guided collection of ovarian 43follicular fluid were done for studying the expression pattern of GDF9 and BMP15 mRNAs using q-PCR. 44Principal Findings: Mid-education level, no contraception usage and duration of infertility for >2 years were 45 the critical risk factors for female infertility (OR>>1; p<0.05), whereas elevated platelet count showed ~10-46 fold more risk of having secondary infertility and high ESR showed 3.33-fold increased threat of primary 47 infertility. Besides, abnormal MCV, LH/FSH ratio, mild-anaemia and hypothyroidism were the best risk-48 predictive multi-factor model. After correcting these abnormal clinical factors, 6.8% of the patients were 49 treatment-non-responsive, where elevated ESR, hypothyroidism and anaemia remained uncorrected. 50Interestingly, in those unexplained cases, GDF9 and BMP15 mRNAs were significantly down-regulated (2-4 51 fold) irrespective of age groups. Additionally, for predicting female infertility, the cut-off for the expression 52 level of GDF9 and BMP15 mRNAs were estimated -2.09 and -2.75, respectively, with a relatively high 53 sensitivity (≥62.5%) and specificity (75%). 54Conclusions: GDF9 and BMP15 mRNAs may be considered as molecular markers for predicting female 55 infertility. Their down-regulation along with hypothyroidism and anaemia probably led to the treatment-non-56 responsiveness, thus, those patients may be advised to assisted reproductive technology with supplementation 57 of exogenous GDF9 and/or BMP15. 58 59 3 60 Introduction 61A female proclaims her superiority by the power of nurturing a new life in her womb, which 62 provides a fertile ground for conception and the healthy growth of a foetus by convention. When this 63 power is curtailed due to the presence of various antagonizing factors that make pregnancy 64 unconventional and futile, the terminology infertility is applied. World Health Organisat...

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Relationship between Hypothyroidism and Endometrial Cancer

Cited by 24 publications

References 52 publications

The Role of Metabolic Syndrome in Endometrial Cancer: A Review

The Role of Metabolic Syndrome in Endometrial Cancer: A Review

Prospective role of thyroid disorders in monitoring COVID-19 pandemic

Down-regulatedGDF9andBMP15mRNAs are the important determining factors for the unexplained female infertility cases advised for assisted reproductive technology

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