Relationship between hypothyroidism and periodontitis: A scoping review

Abstract

Aim The objective of this study was to assess the existing literature to determine if a relationship exists between hypothyroidism and periodontitis. Methods We used a modified approach to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses by searching five databases in addition to the gray literature. Keywords in the title and abstract fields, as well as subject headings for both periodontal disease and hypothyroidism, were used to search the existing literature for publications relevant to evaluation of the thyroid–periodontitis relationship. Results The authors screened 847 unique publications which, after applying inclusion and exclusion criteria, yielded 29 publications, which were further analyzed for relevance and applicability. Most of the included papers were cross‐sectional studies and retrospective chart reviews. Following critical analysis, four publications, including one abstract, were used to further assess the hypothyroid–periodontitis relationship. Conclusions There are very few high‐quality studies describing the potential association between hypothyroidism and periodontitis. In general, and among the included papers with the fewest confounding factors, a positive relationship between hypothyroidism and periodontitis was found. Further well‐controlled, prospective clinical and immunologic studies will be required to confirm that relationship.

Periodontal Condition and Subgingival Microbiota Characterization in Subjects with Down Syndrome

“…Since the endocrine system can modulate the immune system in a bidirectional manner [52] and, in a recent scoping review, on 29 selected articles, a positive relationship between hypothyroidism and periodontitis was found [53], thus the findings of the present study are totally unexpected. One possible explanation is that periodontitis patients are actually suffering subclinical hypothyroidism and/or they have not yet been properly diagnosed [54], and, this were true, the surveillance of hypothyroid hormone function can be further supported in DS individuals.…”

Disposable or not?

“…3 A literature review demonstrated a bidirectional association between hypothyroidism and periodontal disease. 4 The following points are relevant: 1. For dental patients and those with thyroid disease, regular extra-oral clinical examination of the head and neck is vital 2.…”

“…Instead, this has been due to the ability to escalate beds and surgical capacity. 4 The main increases in capacity have been the independent sector and the creation of cancer hubs. Some regions have more private hospitals, so finding additional operative capacity is relatively easier.…”

Transcriptomic Analysis Reveals Genetic Cross-Talk between Periodontitis and Hypothyroidism

“…It has been reported that a reduction in serum levels of thyroid hormones, as clinically present in HT, increases the bone loss related to periodontal inflammation in animal model [ 5 ]. Meanwhile, a clinical relationship between PD and HT appears reasonable and is supported by the literature, although the body of evidence is still weak [ 6 ]. This is supported by several findings in recent literature; on the one hand, periodontal therapy was found to positively influence the thyroid status, whereby Interleukin 6 and TNF alpha were revealed as potential key players [ 7 ].…”