Relationship between<i>Helicobacter pylori</i>Infections in Diabetic Patients and Inflammations, Metabolic Syndrome, and Complications

Kayar, Yusuf; Pamukcu, Ozgul; Eroğlu, Hatice; Erol, Kübra Kalkan; İlhan, Ayşegül; Kocaman, Orhan

doi:10.1155/2015/290128

Cited by 30 publications

(31 citation statements)

References 20 publications

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“…Another 34 articles were excluded (12 were not observational studies, one did not include control group, one duplicate, and the other 20 did not report an outcome of interest). Subsequently, 18 studies including 15 cross‐sectional studies and three cohort studies involving 27 544 participants met our inclusion criteria and were included in the meta‐analysis. The search methodology is outlined in Fig.…”

Section: Resultsmentioning

confidence: 99%

Association between Helicobacter pylori infection and metabolic syndrome: a systematic review and meta‐analysis

Upala

Jaruvongvanich

Riangwiwat

et al. 2016

J of Digest Diseases

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Section: Resultsmentioning

confidence: 99%

Association between Helicobacter pylori infection and metabolic syndrome: a systematic review and meta‐analysis

Upala

Jaruvongvanich

Riangwiwat

et al. 2016

J of Digest Diseases

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“…Furthermore, the H. pylori infection rate was significantly higher in patients with T2DM and DPG than in those without DPG, suggesting that patients with T2DM with H. pylori infection are more likely to develop the clinical manifestations of gastroparesis. The higher H. pylori infection rate in patients with diabetes may be explained by the following mechanisms:[ 7 8 9 10 11 ] (1) diabetes-related deficiencies in cellular and humoral immunity can increase H. pylori susceptibility; (2) mechanical and potential changes in the stomach due to diabetic autonomic neuropathy may lower the gastric mucosa's ability to remove bacteria; and (3) in patients with diabetes, nonenzymatic mucin glycosylation can increase salivary mucin in the gastric mucosa and thus promote the binding of H. pylori with the gastric mucosa.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Relationship between Helicobacter pylori Infection and Diabetic Gastroparesis

Huang

2017

Chinese Medical Journal

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Background:Whether Helicobacter pylori infection is associated with diabetic gastroparesis (DGP) is unclear. This study aimed to investigate the potential correlation between H. pylori infection and DGP.Methods:In this study, 163 patients with type 2 diabetes mellitus and 175 nondiabetic patients who were treated in our department were divided into DGP, simple diabetes, non-DGP (NDG), and normal groups based on their conditions. The H. pylori infection rate in each group was calculated. H. pylori eradication therapy was performed for patients with H. pylori infection in each group. The eradication rates were compared between the groups, and the improvements in gastroparesis-associated symptoms were compared before and after treatment in patients with DGP.Results:The H. pylori infection rate was 74.6% in the DGP group, which was significantly higher than that in the simple diabetes (51.1%, P < 0.01), NDG (57.7%, P < 0.05), and normal groups (48.0%, P < 0.01). With increased disease course, the incidence of DGP and the H. pylori infection rate gradually increased (P < 0.05). In the DGP group, the incidences of upper abdominal pain and distention, early satiety, and anorexia were 75.5%, 66.0%, and 67.9%, respectively, before eradication treatment; and 43.4%, 35.8%, and 39.6%, respectively, after eradication treatment, and the difference was statistically significant (P < 0.01). In patients with DGP with successful H. pylori eradication, the number of barium strips discharged after eradication was 5.9 ± 1.0, which was significantly larger than that before treatment (4.1 ± 0.7, P < 0.01). In addition, the number of barium strips discharged was significantly larger in patients with DGP with successful H. pylori eradication than those with failed H. pylori eradication (P < 0.01).Conclusions:DGP development might be associated with H. pylori infection. H. pylori eradication can effectively improve dyspepsia-associated symptoms and delayed gastric emptying in patients with DGP.

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“…In general, various studies have investigated the role of H. pylori in the pathogenesis of diabetes and its complications, but the results are inconsistent with each other. For example, some case-control studies have reported higher prevalence of H. pylori in patients with diabetes [14,15]. Also, several crosssectional studies have shown a significant statistical association between H. pylori and diabetes [3,15].…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori infection as a risk factor for diabetes: a meta-analysis of case-control studies

et al. 2020

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Background: There are several studies with varied and mixed results about the possible relationship between H. pylori and diabetes. Therefore, this current meta-analysis performed to determine the association between H. pylori infection and the risk of diabetes mellitus. Methods: A systematic literature searches of international databases, including Medline (PubMed), Web of Sciences, Scopus, EMBASE, and CINHAL (January 1990-March 2019) was conducted to identify studies investigating the relationship between H. pylori infection and diabetes mellitus. Only case-control studies were analyzed using odds ratio (OR) with 95% confidence intervals (CIs). Stratified and subgroup analyses were performed to explore heterogeneity between studies and assess effects of study quality. Logarithm and standard error logarithm odds ratio (OR) were also used for meta-analysis. Results: A total of 41 studies involving 9559 individuals (case; 4327 and control; 5232) were analyzed. The pooled estimate of the association between H. pylori infection with diabetes was OR = 1.27 (95% CI 1.11 to 1.45, P = 0.0001, I 2 = 86.6%). The effect of H. pylori infection on diabetes mellitus (both types), type 1 and type 2 diabetes was 1.17 (95% CI 0.94 to 1.45), 1.19 (95% CI 0.98 to 1.45), and 1.43 (95% CI 1.11 to 1.85) respectively. Subgroup analysis by the geographical regions showed in Asian population risk of the effect of H. pylori infection on diabetes was slightly higher than other population, Conclusion: In overall a positive association between H. pylori infection and diabetes mellitus was found.

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Relationship betweenHelicobacter pyloriInfections in Diabetic Patients and Inflammations, Metabolic Syndrome, and Complications

Cited by 30 publications

References 20 publications

Association between Helicobacter pylori infection and metabolic syndrome: a systematic review and meta‐analysis

Association between Helicobacter pylori infection and metabolic syndrome: a systematic review and meta‐analysis

Analysis of the Relationship between Helicobacter pylori Infection and Diabetic Gastroparesis

Helicobacter pylori infection as a risk factor for diabetes: a meta-analysis of case-control studies

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