Relationship Between IL1 Gene Polymorphism and Susceptibility to Ankylosing Spondylitis: An Updated and Supplemented Meta-Analysis

Gao, Meng; Li, Teng; Song, Zelong; Wang, Xiangyu; Liu, WeiBo

doi:10.1007/s10528-021-10149-5

Cited by 4 publications

(3 citation statements)

References 27 publications

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“…Our conclusion is based on the results of a meta-analysis of five IL-1β SNPs. These discrepancies may arise from factors such as small sample sizes, low statistical power, clinical heterogeneity, and racial differences ( 37 ). In the future, further research will be needed to clarify the causal relationship between IL-1β and AS.…”

Section: Discussionmentioning

confidence: 99%

Exploring causal correlations between inflammatory cytokines and ankylosing spondylitis: a bidirectional mendelian-randomization study

Fang,

Liu,

Qiu

et al. 2023

Front. Immunol.

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BackgroundThe impact of inflammatory factors on the development of Ankylosing Spondylitis (AS) is widely recognized, but the exact causal relationship remains unclear.MethodsThe bidirectional mendelian-randomization study utilized genetic data from a genome-wide association study (GWAS) of 186 AS cases and 456,162 controls of European ancestry. Inflammatory cytokines were obtained from a GWAS summary of 8,293 healthy participants. Causal associations were primarily investigated using the inverse variance-weighted method, supplemented by MR Egger, weighted median and weighted mode analyses. Heterogeneity in the results was assessed using the Cochrane Q test. Horizontal pleiotropy was evaluated through the MR-Egger intercept test and the MR pleiotropy residual sum and outliers (MR-PRESSO) test. Sensitivity analysis was conducted through leave-one-out analysis.ResultsThe results suggest a genetically predicted potential association between beta-nerve growth factor (βNGF), Interleukin-1-beta (IL-1β), and TNF-related apoptosis inducing ligand (TRAIL) with the risk of AS (OR: 2.17, 95% CI: 1.13-4.16; OR: 0.41, 95% CI: 0.18-0.95,; OR: 1.47, 95% CI: 1.02-2.13).Additionally, Interleukin-12p70 (IL-12p70), Interleukin-17 (IL-17), Interleukin-6 (IL-6), Interleukin-4 (IL-4), Stromal-cell-derived factor 1 alpha (SDF−1α), Macrophage inflammatory protein 1β (MIP1β), Monocyte chemoattractant protein-3 (MCP-3), Platelet-derived growth factor bb (PDGFbb), Granulocyte-colony stimulating factor (GCSF), Fibroblast growth factor basic (bFGF), TNF-related apoptosis inducing ligand (TRAIL), and Interferon-gamma (IFN -γ) are suggested as consequences of AS in genetically prediction.No evidence of horizontal pleiotropy or heterogeneity between the genetic variants was found (P>0.05), and a leave-one-out test confirmed the stability and robustness of this association.ConclusionThese findings suggest that βNGF, IL-1β, and TRAIL may play a crucial role in the pathogenesis of AS. Additionally, AS may impact the expression of cytokines such as IL-12p70, IL-17, IL-6, IL-4, SDF−1α, MIP1β, MCP-3, PDGFbb,GCSF, bFGF,TRAIL,and IFN-γ. Further investigations are warranted to determine whether these biomarkers can be utilized for the prevention or treatment of AS.

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Section: Discussionmentioning

confidence: 99%

Exploring causal correlations between inflammatory cytokines and ankylosing spondylitis: a bidirectional mendelian-randomization study

Fang,

Liu,

Qiu

et al. 2023

Front. Immunol.

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“…Other factors taken into account were interleukin (IL)-1 and IL-23 receptor (-R) genes. Concerning IL-1, from a metanalysis of Chinese and English databases, it was found out that the IL-1A-889 (rs1800587) allele was significantly correlated with AS while IL1F7 exon 2 (rs3811047) G allele polymorphism was significantly associated to a lower risk of developing AS (20). Another metanalysis evaluated the association between IL-23R polymorphisms and autoimmune diseases susceptibility.…”

Section: Genetics and Pathogenesismentioning

confidence: 99%

“…• Some SNPs of both ERAP1/2, TNF-α, IL-1A, IL-23A-R and CTLA-4 genes seem to be associated with a higher probability of developing AS, with different pattern of risk based on ethnicity (16)(17)(18)(19)(20)(21)(22)(23)(24)(25). • An imbalance in lymphocytes subsets seems to be involved in ax-SpA pathogenesis and the administration of symbiotics does not seem to correct it (26-28).…”

Section: Take-home Messagesmentioning

confidence: 99%

Axial spondyloarthritis: one year in review 2023

Fattorini,

Gentileschi,

Cigolini

et al. 2023

Clinical and Experimental Rheumatology

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Axial spondyloarthritides (axSpA) are a group of systemic autoimmune diseases, characterised by an inflammatory involvement of the axial skeleton, which, in the earlier phases, cannot be detected by conventional radiology, but only by magnetic resonance imaging, thus defining the so-called non-radiographic axSpA (nr-axSpA). The initial osteitis then tends to complicate into bone reabsorption and aberrant bone deposition, which then determines the ankylosis of the axial skeleton in the latest phases of the disease. Peripheral joints may also be affected, enthesitis being its more characteristic manifestation. The radiographic form corresponds to ankylosing spondylitis which, with psoriatic arthritis, is the best-known subtype of SpA. AxSpA are rarely associated to laboratory abnormalities and are usually complicated by the presence of both extra-articular manifestations (particularly acute anterior uveitis, psoriasis and inflamatory bowel disease) and comorbidities, with a subsequent higher risk for patients of an impaired quality of life. In this paper we reviewed the literature on axSpA of 2021 and 2022 (Medline search of articles published from 1st January 2021 to 31st December 2022).

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MICA and NLRP3 gene polymorphisms interact synergistically affecting the risk of ankylosing spondylitis

Fernández-Torres,

Zamudio-Cuevas,

Ruiz-Dávila

et al. 2023

Immunol Res

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Relationship Between IL1 Gene Polymorphism and Susceptibility to Ankylosing Spondylitis: An Updated and Supplemented Meta-Analysis

Cited by 4 publications

References 27 publications

Exploring causal correlations between inflammatory cytokines and ankylosing spondylitis: a bidirectional mendelian-randomization study

Exploring causal correlations between inflammatory cytokines and ankylosing spondylitis: a bidirectional mendelian-randomization study

Axial spondyloarthritis: one year in review 2023

MICA and NLRP3 gene polymorphisms interact synergistically affecting the risk of ankylosing spondylitis

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