Relationship between IL28B gene rs8099917 polymorphism and SVR in Turkish patients with hepatitis C virus genotype 1

Akkız, Hikmet; Akgöllü, Ersin; Bekar, Aynur; Yıldırım, Selçuk; Sandikci, Macit; Ülger, Yakup; Kaya, Berrin Yalınbaş; Kuran, Sedef; Üsküdar, Oǧuz

doi:10.1016/j.clinre.2015.02.008

Cited by 5 publications

(3 citation statements)

References 41 publications

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“…In Asian CHB patients mostly infected genotypes other than D (genotypes A, B, C). But in Turkey, genotype D is by a percentage of 78% (7). Martin MP et al (8) reported that the C/C genotype of rs12979860 was not associated with HBV recovery, but in that Abbreviations; IFN: Interferon, HBeAg: Hepatitis B e antigen, HBV-DNA: Hepatitis B virus deoxyribonucleic acid study, 20% of the patients were HCV and 69% were HIV positive patients.…”

Section: Discussionmentioning

confidence: 99%

Kronik Hepatit B Enfeksiyonu ile İnterlökin-28B Gen Polimorfizminin İlişkisi

2022

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Aim: Interleukin 28B (IL28B) gene polymorphism may play a role in hepatitis B virus (HBV) infection prognosis. We investigated the effects of IL28B gene polymorphism on viral clearance and viral load in chronic hepatitis B (CHB) patients. Material and Methods: We included 146 individuals who applied to our center between October 2011 and October 2012. CHB (N=117) and control (N=29) groups were compared in terms of IL28B gene rs12979860, rs12980275 gene region polymorphisms, and IL28B gene expression (mRNA) levels. Results: There was no statistically significant difference between groups in terms of rs12979860 gene region polymorphism rates (χ2=0.36, p=0.835). But there was a significant association between groups in terms of rs12980275. In the CHB group, the A/A genotype was much more, (χ2=55.2, p<0.001), G/A and G/G genotypes were less frequent. There was no statistically significant difference between the groups in terms of IL28B expression levels. Conclusion:This study revealed the genotype profile of the IL28B gene of our region. It is the first study on this subject in our region. The association between CHB and rs12980275 polymorphism may be important. Our results will contribute to future studies.

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Section: Discussionmentioning

confidence: 99%

Kronik Hepatit B Enfeksiyonu ile İnterlökin-28B Gen Polimorfizminin İlişkisi

2022

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“…Previous studies demonstrated that genetic factors play an important role in HCV infection, in addition to some well‐understood factors such as age and liver function . A significant association was found between HCV infection and gene polymorphisms in immune‐related genes, such as interleukin‐family, toll‐like receptor (TLR), patatin‐like phospholipase domain containing 3, interferon lambda 4, and inosine triphosphate pyrophosphatase . Given the important biological function of RLRs in HCV infection, it is essential to explore the potential influence between RLR gene polymorphisms and HCV infection.…”

Section: Introductionmentioning

confidence: 99%

“…12 A significant association was found between HCV infection and gene polymorphisms in immune-related genes, such as interleukin-family, toll-like receptor (TLR), patatin-like phospholipase domain containing 3, interferon lambda 4, and inosine triphosphate pyrophosphatase. [13][14][15][16][17][18][19][20][21][22] Given the important biological function of RLRs in HCV infection, it is essential to explore the potential influence between RLR gene polymorphisms and HCV infection. However, research on the association between mutations in RLR-related genes and HCV infection are scant currently.…”

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Genetic variants in IFIH1 and DDX58 influence hepatitis C virus clearance in Chinese Han population

Zhu¹,

Zhuo

Yue

et al. 2019

Journal of Medical Virology

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Aims To investigate the association between two RIG‐I‐like receptor gene polymorphisms and hepatitis C virus (HCV) infection in Chinese Han population. Methods The current study genotyped two selected SNPs (IFIH1 rs3747517 and DDX58 rs9695310) using TaqMan allelic discrimination assay to assess their association with the susceptibility and clinical outcome of HCV infection among 3065 participants (1545 non‐HCV infection individuals, 568 spontaneous HCV clearance cases, and 952 persistent infection patients). Results IFIH1 rs3747517 (dominant model: Adjusted odds ratio [OR] = 1.34, 95% confidence interval [CI] = 1.07‐1.68; P = 0.009) and DDX58 rs9695310 (dominant model: Adjusted OR = 1.43, 95% CI = 1.15‐1.78; P = 0.001) were associated with chronic hepatitis C (CHC). And the risk of CHC increased when people were carrying more unfavorable rs3747517‐GA/AA and rs9695310‐GC/CC genotypes from zero to two with the chronic rates of 56.72%, 59.38%, and 69.01%, respectively (Ptrend < 0.001). Conclusion Genetic variations at IFIH1 rs3747517 and DDX58 rs9695310 were independent predictors of chronic hepatitis C in Chinese Han population.

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EGFR rs11506105 and IFNL3 SNPs but not rs8099917 are strongly associated with treatment responses in Iranian patients with chronic hepatitis C

et al. 2017

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Interferon lambda 3 (IFNL3) and epidermal growth factor receptor (EGFR) single nucleotide polymorphisms (SNPs) may play a key role in the spontaneous clearance of hepatitis C virus (HCV) and treatment responses. The aim of this study was to evaluate the effect of IFNL3 SNPs and EGFR rs11506105 on treatment outcomes in patients with chronic HCV (CHC). IFNL3 SNPs and EGFR rs11506105 were genotyped by PCR-restriction fragment length polymorphism and PCR-sequencing, respectively, in 235 naïve patients with CHC infection. The frequency of rapid virologic response (RVR), complete early virologic response (cEVR) and sustained virologic response (SVR) were 52.3%, 76.2% and 64.7% respectively. The results of this study showed that RVR was associated with ALT (P=0.015), AST (P=0.020), IFNL3 rs12979860 (CC) (P=0.043), rs12980275 (AA) (P=1 × 10), and EGFR rs11506105 (AA) (P=0.010), and IFNL3 rs12979860 (CC) (P=0.048), rs12980275 (AA) (P=0.022), and EGFR rs11506105 (AA) (P=0.006) were correlated with cEVR. HCV genotype (P=0.007), IFNL3 rs12979860 (CC) (P=0.023), IFNL3 rs12980275 (AA) (P=1 × 10), EGFR rs11506105 (AA) (P=0.005), RVR (P=1 × 10), and cEVR (P=0.003) were significant predictors for SVR. These results, for the first time, revealed that beside IFNL3 SNPs, EGFR rs11506105 is strongly associated with RVR, cEVR and SVR. EGFR rs11506105 besides IFNL3 SNPs could predict treatment responses in CHC patients.

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Relationship between IL28B gene rs8099917 polymorphism and SVR in Turkish patients with hepatitis C virus genotype 1

Cited by 5 publications

References 41 publications

Kronik Hepatit B Enfeksiyonu ile İnterlökin-28B Gen Polimorfizminin İlişkisi

Kronik Hepatit B Enfeksiyonu ile İnterlökin-28B Gen Polimorfizminin İlişkisi

Genetic variants in IFIH1 and DDX58 influence hepatitis C virus clearance in Chinese Han population

EGFR rs11506105 and IFNL3 SNPs but not rs8099917 are strongly associated with treatment responses in Iranian patients with chronic hepatitis C

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