Relationship between inflammation and metabolic syndrome following treatment with paliperidone for schizophrenia

Na, Kyoung-Sae; Kim, Won-Hyoung; Jung, Han‐Yong; Ryu, Seong Gon; Min, Kyung Joon; Park, Ki-Chang; Kim, Yong-Sik; Yoon, Jin‐Sang; Ahn, Yong Min; Kim, Chul-Eung

doi:10.1016/j.pnpbp.2012.06.024

Cited by 16 publications

(20 citation statements)

References 37 publications

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“…Inflammation is recognised as an integral component of both metabolic syndrome and psychiatric disorders (Hope 2009;Na 2012), with high serum levels of C-reactive protein (CRP) and proinflammatory cytokines such as interleukin IL-6 and tumour necrosis factoralpha (TNF-α) in both conditions. Genetic factors such as the presence of specific genes responsible for a predisposition to metabolic problems and variations in the leptin-melanocortin pathway that contribute to heterogeneity in antipsychoticinduced weight gain are also important causes of metabolic syndrome.…”

Section: Declaration Of Interestmentioning

confidence: 99%

“…As for leptin, which may impair insulin action, it enhances inflammation by increasing the synthesis of TNF-α and IL-6. There is growing evidence to suggest that inflammation contributes to the development of metabolic syndrome in patients with schizophrenia (Na 2012). Both schizophrenia and obesity demonstrate a decrease in adiponectin and increase in leptin, with raised TNF-α and IL-6.…”

Section: Chronic Inflammationmentioning

confidence: 99%

“…Abnormal baseline levels of IL-6 were found to predict significantly greater elevations in both total cholesterol and low-density lipoprotein (LDL) following a 12-week treatment with olanzapine (Fernandez-Egea 2011). Total white blood cell count, one of the surrogate parameters of inflammation, has been found to be a risk factor for metabolic syndrome, its values positively correlating with the increase in waist circumference and glucose during a 24-week treatment with paliperidone (Na 2012).…”

Section: Chronic Inflammationmentioning

confidence: 99%

See 2 more Smart Citations

Metabolic syndrome in psychiatry: advances in understanding and management

Ho¹,

Zhang²,

Mak³

et al. 2014

Adv. psychiatr. treat

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SummaryMetabolic syndrome comprises a number of cardiovascular risk factors that increase morbidity and mortality. The increase in incidence of the syndrome among psychiatric patients has been unanimously demonstrated in recent studies and it has become one of the greatest challenges in psychiatric practice. Besides the use of psychotropic drugs, factors such as genetic polymorphisms, inflammation, endocrinopathies and unhealthy lifestyle contribute to the association between metabolic syndrome and a number of psychiatric disorders. In this article, we review the current diagnostic criteria for metabolic syndrome and propose clinically useful guidelines for psychiatrists to identify and monitor patients who may have the syndrome. We also outline the relationship between metabolic syndrome and individual psychiatric disorders, and discuss advances in pharmacological treatment for the syndrome, such as metformin.LEARNING OBJECTIVES•Be familiar with the definition of metabolic syndrome and its parameters of measurement.•Appreciate how individual psychiatric disorders contribute to metabolic syndrome and vice versa.•Develop a framework for the prevention, screening and management of metabolic syndrome in psychiatric patients.

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Section: Declaration Of Interestmentioning

confidence: 99%

Section: Chronic Inflammationmentioning

confidence: 99%

Section: Chronic Inflammationmentioning

confidence: 99%

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Metabolic syndrome in psychiatry: advances in understanding and management

Ho¹,

Zhang²,

Mak³

et al. 2014

Adv. psychiatr. treat

View full text Add to dashboard Cite

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“…WBC count was mildly correlated with MetS in the correlation analysis, while in the regression analysis it was one of the predictors of MetS. Three previous studies reported that a higher WBC count was associated with MetS (7)(8)(9). One of these studies determined that changes in WBC count were positively correlated with changes in waist circumference during a 24-week antipsychotic treatment period (7).…”

Section: Discussionmentioning

confidence: 94%

“…Three previous studies reported that a higher WBC count was associated with MetS (7)(8)(9). One of these studies determined that changes in WBC count were positively correlated with changes in waist circumference during a 24-week antipsychotic treatment period (7). In addition, total WBC count predicted the future development of MetS in the general population (9).…”

Section: Discussionmentioning

confidence: 99%

Total white blood cell count, liver enzymes, and metabolic syndrome in schizophrenia

et al. 2016

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Background/aim: Metabolic syndrome (MetS) is an important clinical issue in patients with schizophrenia, but its associated factors are still ambiguous. The aim of the present study was to test whether there are any associations between MetS and white blood cell (WBC) levels, liver enzymes, or sociodemographic variables. Materials and methods:The study included 91 patients with a diagnosis of schizophrenia. We used the National Cholesterol Education Program's Third Adult Treatment Protocol criteria to evaluate MetS in patients. Schizophrenia patients with MetS were compared with those without MetS on the basis of demographic and clinical characteristics and total WBC counts. We conducted Spearman's correlation and binary logistic regression analyses to achieve the best prediction of MetS in schizophrenia.Results: Compared with schizophrenia patients without MetS, those with MetS were older, less educated, and more likely to be smokers. They were also more likely to have a longer duration of the illness, a longer untreated period, and higher alanine aminotransferase (ALT) and WBC levels. MetS was correlated with age, duration of illness, income, ALT, gamma-glutamyl transpeptidase, WBC, and hemoglobin values. Age and WBC levels were found to be the best predictors of MetS. Conclusion:Hemograms and liver tests should be conducted to test for MetS in schizophrenia.

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A meta-analysis of cardio-metabolic abnormalities in drug naïve, first-episode and multi-episode patients with schizophrenia versus general population controls

et al. 2013

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A meta-analysis was conducted to explore the risk for cardio-metabolic abnormalities in drug naïve, first-episode and multi-episode patients with schizophrenia and age- and gender- or cohort-matched general population controls. Our literature search generated 203 relevant studies, of which 136 were included. The final dataset comprised 185,606 unique patients with schizophrenia, and 28 studies provided data for age- and gender-matched or cohort-matched general population controls (n=3,898,739). We found that multi-episode patients with schizophrenia were at increased risk for abdominal obesity (OR=4.43; CI=2.52-7.82; p<0.001), hypertension (OR=1.36; CI=1.21-1.53; p<0.001), low high-density lipoprotein cholesterol (OR=2.35; CI=1.78-3.10; p<0.001), hypertriglyceridemia (OR=2.73; CI=1.95-3.83; p<0.001), metabolic syndrome (OR=2.35; CI=1.68-3.29; p<0.001), and diabetes (OR=1.99; CI=1.55-2.54; p<0.001), compared to controls. Multi-episode patients with schizophrenia were also at increased risk, compared to first-episode (p<0.001) and drug-naïve (p<0.001) patients, for the above abnormalities, with the exception of hypertension and diabetes. Our data provide further evidence supporting WPA recommendations on screening, follow-up, health education and lifestyle changes in people with schizophrenia.

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Relationship between inflammation and metabolic syndrome following treatment with paliperidone for schizophrenia

Cited by 16 publications

References 37 publications

Metabolic syndrome in psychiatry: advances in understanding and management

Metabolic syndrome in psychiatry: advances in understanding and management

Total white blood cell count, liver enzymes, and metabolic syndrome in schizophrenia

A meta-analysis of cardio-metabolic abnormalities in drug naïve, first-episode and multi-episode patients with schizophrenia versus general population controls

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