Relationship Between Initial Volumetric 68Ga-PSMA PET/CT Parameters, and Clinical and Histopathological Data in Patients with Newly Diagnosed Prostate Cancer

Abstract

Purpose: To evaluate the relationships between volumetric 68Ga-PSMA PET/CT parameters, Gleason Score (GS), Gleason Grade (GG), PSA levels, histopathological data, and metastatic status in newly diagnosed prostate cancer (PCa) patients. Methods: A total of 78 newly diagnosed PCa patients who had 68Ga-PSMA PET/CT scan were included in this study. Clinical parameters, histopathological data, and metastatic status were documented, volumetric parameters were measured. All obtained data were compared statistically. Results: Gleason Score, GG, and SUVmax had a significant relationship with serum PSA levels (p<0.05). PSA levels and SUVmax values ​​of patients with lymph node metastases were found to be significantly higher than those without. GG and the sum of GS were found to be statistically significantly increased in metastatic patients. PSMA-TV and TL-PSMA of the primary lesion, have a significant relationship with PSA value, GS, and regional lymph node metastases. When the relationships between histopathological data with PSA level, GG, SUVmax, PSMA-TV, and TL-PSMA were compared; A significant correlation was observed between all except PNI and TL-PSMA. ROC analysis was performed in patients with metastatic and localized disease, and the cutoff value for SUVmax was found to be 10.85. Conclusion: Correlations between PSA values ​​and GG, lymph node metastasis, SUVmax, and histopathological data support the crucial role of 68Ga-PSMA PET/CT in the initial evaluation of PCa patients. In our study, we concluded that 68Ga-PSMA PET/CT is an effective tool and the effects of clinical, histopathological, and imaging-based parameters in prostate cancer patients should be well known.