Relationship between Insulin-Like Growth Factor I Levels, Early Insulin Treatment, and Clinical Outcomes of Very Low Birth Weight Infants

Beardsall, Kathryn; Vanhaesebrouck, Sophie; Frystyk, Jan; Ogilvy-Stuart, Amanda; Vanhole, Christine; Weissenbruch, Mirjam M. van; Midgley, Paula; Thió, Marta; Cornette, Luc; Gill, Bryan; Ossuetta, Iviano; Iglésias, Isabel; Theyskens, Claire; Jong, Miranda de; Ahluwalia, Jag; Zegher, Francis de; Dunger, David B.

doi:10.1016/j.jpeds.2013.12.046

Cited by 30 publications

(27 citation statements)

References 22 publications

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“…IGF-I is one of the most important regulators of postnatal growth and is known to be lower in placental tissues and cord blood in women with severe, but not mild, PE [26, 27]. Therefore, poor linear growth in children exposed to severe PE might be due to effects on the growth hormone- IGF-1 axis [28–30], an effect that might be mediated through inflammation or perhaps the result of fetal programming. PE is characterized by inflammation and the cytokines of pregnancy could correlate with those in offspring until the age of 1 year [31, 32].…”

Section: Discussionmentioning

confidence: 99%

Exposure to preeclampsia in utero affects growth from birth to late childhood dependent on child’s sex and severity of exposure: Follow-up of a nested case-control study

et al. 2017

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Background and objectiveAn adverse intrauterine environment may affect offspring growth and development. Our aim was to explore whether preeclampsia (PE) exposure in utero influences growth from birth to 13 years.MethodsIn a nested case-control study, 229 children were exposed to PE (mild/moderate: n = 164, severe: n = 54) and 385 were unexposed. Length/height and weight were abstracted from records at birth, 3 and 6 months, 1 and 4 years, and measured along with waist circumference and skinfolds at follow-up at 11/12 (girls/boys) and 13 years (both sexes). Associations between PE and z-scores for growth were analyzed by multiple linear and fractional polynomial regression with adjustment for potential confounders.ResultsIn boys, exposure to mild/moderate PE was positively associated with linear growth after 0.5 years, but severe PE was negatively associated with linear growth in all ages. In girls, both exposure to mild/moderate and severe PE were negatively associated with linear growth. Exposure to PE was negatively associated with weight and body mass index (BMI) during infancy, but positively associated with weight and BMI thereafter, except that boys exposed to severe PE consistently had a lower weight and BMI compared to the unexposed. Exposure to severe PE only was positively associated with waist-to-height ratio at 11/12 (girls/boys) and 13 years (both sexes).ConclusionsFrom birth to adolescence, linear growth, weight and BMI trajectories differed between the sexes by severity of exposure to PE. In general, PE exposure was negatively associated with linear growth, while in girls; positive associations with weight and BMI were observed. This underlines fetal life as a particularly sensitive period affecting subsequent growth and this may have implications for targeted approaches for healthy growth and development.

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Section: Discussionmentioning

confidence: 99%

Exposure to preeclampsia in utero affects growth from birth to late childhood dependent on child’s sex and severity of exposure: Follow-up of a nested case-control study

et al. 2017

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“…[38][39][40][41][42] Higher levels of plasma IGF-1 were also associated with reduced incidence of NEC in a prospective analysis of very low birth weight infants in the NIRTURE study. 43 The administration of IGF-1/ IGFBP3 would not be expected to increase the risk of NEC.…”

Section: Discussionmentioning

confidence: 99%

rhIGF-1/rhIGFBP-3 in preterm Infants: A phase 2 randomized controlled trial

Ley¹,

Hallberg²,

Hansen‐Pupp³

et al. 2019

ESPE

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on behalf of the study team* Objective To investigate recombinant human insulin-like growth factor 1 complexed with its binding protein (rhIGF-1/rhIGFBP-3) for the prevention of retinopathy of prematurity (ROP) and other complications of prematurity among extremely preterm infants.Study design This phase 2 trial was conducted from September 2014 to March 2016. Infants born at a gestational age of 23 0/7 weeks to 27 6/7 weeks were randomly allocated to rhIGF-1/rhIGFBP-3 (250 µg/kg/ 24 hours, continuous intravenous infusion from <24 hours of birth to postmenstrual age 29 6/7 weeks) or standard neonatal care, with follow-up to a postmenstrual age of 40 4/7 weeks. Target exposure was ≥70% IGF-1 measurements within 28-109 µg/L and ≥70% intended therapy duration. The primary endpoint was maximum severity of ROP. Secondary endpoints included time to discharge from neonatal care, bronchopulmonary dysplasia, intraventricular hemorrhage, and growth measures.

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“…Insulin-like growth factor 1 (IGF-1) is a single-stranded polypeptide that is regulated by growth hormones. Thus, circulating IGF-1 levels may indicate the activity of growth hormones and the progress of maturation in VLBWPIs (1,4). Previous studies have revealed that IGF-1 is essential for postnatal growth and development in humans (5), and that low levels of IGF-1 may be involved in the prolonged growth restriction of VLBWPIs (6).…”

Section: Introductionmentioning

confidence: 99%

“…Very low birth weight premature infants (VLBWPIs) are cared for in the neonatal intensive care unit (NICU), which must meet the requirements of a restful and a stress-free environment (1). It has been reported that during the first 2 weeks following birth, touch, sound and light stimulation in the NICU are positively associated with median diastolic blood pressure, mean arterial pressure and infant movement (2,3).…”

Section: Introductionmentioning

confidence: 99%

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Reduced environmental stimuli is associated with improved insulin‑like growth factor‑1 levels and physical growth in very low birth weight premature infants

et al. 2019

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Standard environmental features of the neonatal intensive care unit (NICU) may be stressful and not optimal for the maturation of very low birth weight premature infants (VLBWPIs). The present study investigated whether structured no-touch periods and reducing periods of light and sound stimulation may influence the developmental indices of VLBWPIs. Between June 2012 and June 2013, 60 consecutive VLBWPIs were equally apportioned to either an experimental or control group. The groups were statistically comparable with regard to sex ratio, gestational age and birth weight. Each group received routine nursing care, but infants in the experimental group were additionally cared for in a separate room with 3 h of rest every 8 h, and reduced light and sound from staff and instruments. At 7 and 14 days following birth, plasma insulin-like growth factor 1 (IGF-1) levels of the experimental group were significantly higher than that of the control group. Furthermore, at day 7 and 14, the body weight and crown-to-heel lengths were significantly increased in the experimental group compared with the control group. In summary, during the first 2 weeks following birth, the reduction of touch, sound and light stimulation in the NICU were associated with higher plasma IGF-1 levels and physical growth of VLBWPIs. These results may have implications for the better management of VLBWPIs in the NICU.

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Relationship between Insulin-Like Growth Factor I Levels, Early Insulin Treatment, and Clinical Outcomes of Very Low Birth Weight Infants

Cited by 30 publications

References 22 publications

Exposure to preeclampsia in utero affects growth from birth to late childhood dependent on child’s sex and severity of exposure: Follow-up of a nested case-control study

Exposure to preeclampsia in utero affects growth from birth to late childhood dependent on child’s sex and severity of exposure: Follow-up of a nested case-control study

rhIGF-1/rhIGFBP-3 in preterm Infants: A phase 2 randomized controlled trial

Reduced environmental stimuli is associated with improved insulin‑like growth factor‑1 levels and physical growth in very low birth weight premature infants

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