Relationship between Insulin Resistance and Effect of Atorvastatin in Non-diabetic Subjects

Yoshitomi, Yuji; Ishii, Toshiharu; Kaneki, Masashi; Tsujibayashi, Takashi; Sakurai, Shogo; Nagakura, Chieko; Miyauchi, Atsuyoshi

doi:10.5551/jat.12.9

Cited by 12 publications

(10 citation statements)

References 20 publications

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“…Esta relación también fue señalada en algunos estudios previos. 30,31 Hay una alta prevalencia de esteatosis hepática no alcohólica en los niños obesos. 32 El desarrollo de esteatosis hepática no alcohólica relacionada con la obesidad es causado por la resistencia a la insulina.…”

Section: Discussionunclassified

La deficiencia de vitamina D y la resistencia a la insulina como factores de riesgo de dislipidemia en niños obesos

2017

Arch Argent Pediat

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Section: Discussionunclassified

La deficiencia de vitamina D y la resistencia a la insulina como factores de riesgo de dislipidemia en niños obesos

2017

Arch Argent Pediat

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“…23,24 Insulin resistance was evaluated by the homeostasis model assessment (HOMA) index, calculated as blood glucose (mmol l À1 )Âinsulin concentration (mIU ml À1 )/22.5. 25,26 Body mass index was calculated as weight (kilograms) divided by height (meters) squared.…”

Section: Methodsmentioning

confidence: 99%

The associations between G972R polymorphism of the IRS-1 gene, insulin resistance, salt sensitivity and non-dipper hypertension

et al. 2011

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The aim of this study was to assess the association between G972R polymorphism of the insulin receptor substrate-1 (IRS-1) gene and the circadian variation in blood pressure, insulin sensitivity and salt sensitivity in subjects with uncomplicated, never-treated essential hypertension receiving low-, normal-and high-salt diets. The study was performed on 115 subjects aged 27.48 ± 5.1 years with never-treated, uncomplicated hypertension. In the 7-day consecutive period of time, subjects received a normal-, low-and high-salt diet. At the end of each dietary regimen, the following parameters were recorded: 24-h blood pressure monitoring, lipid profile, insulin level, glucose level, aldosterone level and plasma renin activity. Insulin resistance was evaluated by the homeostasis model assessment (HOMA). In comparison with Gly/Gly carriers, subjects with the G972R polymorphism had higher concentrations of total and LDL cholesterol and triglycerides and HOMA but lower HDL cholesterol. On a high-salt diet, patients with the G972R polymorphism had an increased risk for insulin resistance (odds ratio (OR)¼11.42, 95% confidence interval (CI) 7.68-28.44), salt sensitivity (OR¼5.38, 95% CI 1.14-25.34) and non-dipper hypertension (OR¼3.6, 95% CI 1.07-12.09). Regardless of the dietary salt intake, blood pressure values were similar between G972R and Gly/Gly carriers. In conclusion, the results of our study suggest that the G972R polymorphism of the IRS-1 gene is associated with insulin resistance, salt sensitivity and non-dipper hypertension.

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“…This relationship was also highlighted in some previous studies. 30,31 Non-alcoholic fatty liver disease is highly prevalent in obese children. 32 Insulin resistance is responsible for the development of obesityrelated non-alcoholic liver disease.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D deficiency and insulin resistance as risk factors for dyslipidemia in obese children

et al. 2017

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ABSTRACT30.4 ± 18.95; p= 0.018) were significantly higher in the children with dyslipidemia. In the dyslipidemic obese children, the average hepatosteatosis rate and HOMA-IR level were higher; 28 (71.9%) had hepatosteatosis, 37 (94.87%) had insulin resistance; the vitamin D levels were <20 ng/ml in 69.3%. Vitamin D deficiency was significantly more common (p= 0.033). The multivariate regression analysis confirmed that the increase in the HOMA-IR level (p= 0.015) and the low vitamin D level (p= 0.04) were important risk factors for dyslipidemia. Conclusion. Obese children in our region exhibit low vitamin D and increased HOMA-IR levels, which are efficient risk factors of dyslipidemia.

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Relationship between Insulin Resistance and Effect of Atorvastatin in Non-diabetic Subjects

Abstract: Background: Although insulin resistance (IR) is present in non-diabetic subjects, it is

Cited by 12 publications

References 20 publications

La deficiencia de vitamina D y la resistencia a la insulina como factores de riesgo de dislipidemia en niños obesos

La deficiencia de vitamina D y la resistencia a la insulina como factores de riesgo de dislipidemia en niños obesos

The associations between G972R polymorphism of the IRS-1 gene, insulin resistance, salt sensitivity and non-dipper hypertension

Vitamin D deficiency and insulin resistance as risk factors for dyslipidemia in obese children

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