Relationship Between Insulin Resistance and Endometrial Cancer: Determination of Key Genes and Pathways

Abstract

Introduction:Epidemiological studies have found that the occurrence of endometrial cancer(EC) is closely related to metabolic diseases, and insulin resistance (IR) plays an important role in the pathogenesis of endometrium, but the specific pathogenesis is still unclear. The purpose of this study is to reveal the relationship between insulin resistance and endothelial cells by gene screening technology. Material and methods:We analyzed one endometrial carcinoma database (GSE106191) and one insulin-resistant database (GSE63992), with Gene Expression Omnibus (GEO) database and Venny online analysis tool, then, we found an add-up to 148 different genes. Functional enrichment analysis of these genes using DAVID showed that they were participated in transcription factor activity,signaling pathways and response to factors, etc. Then used cytoHubba in Cytoscape,we got 25 hub genes.Results: The results showed that the survival time of OGT, IGSF3, TRO, NEURL2 and PIK3C2B was significantly and closely related to EC, and the percentage of gene changes of five central genes ranged from 3% to 10% of a single gene, was also related to the infiltration of seven kinds of immune cells in endometrial carcinoma.Conclusion:The five key genes (OGT,IGSF3, PIK3C2B,TRO and NEURL2) are involved in immune infiltration in the progression of endometrial carcinoma, and there is also a certain mutation probability in gene mutation. This may be the pathogenesis of insulin resistance and endometrial cancer.