Relationship between intracortical electrode design and chronic recording function

Karumbaiah, Lohitash; Saxena, Tarun; Carlson, David; Patil, Ketki; Patkar, Radhika; Gaupp, Eric; Betancur, Martha I.; Stanley, Garrett B.; Carin, Lawrence; Bellamkonda, Ravi V.

doi:10.1016/j.biomaterials.2013.07.016

Cited by 222 publications

(240 citation statements)

References 70 publications

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“…While these results may indicate that mechanical mismatch has limited effects on the chronic inflammatory response, the Tresco lab has observed that microwire implants produce a reduced inflammatory response compared to Michigan-style implants (38). Previous work also has indicated that mechanics and architecture can each independently manipulate the inflammatory response (31, 39–41). Additionally, we have previously reported that rigid silicon implants show a mid-term recovery phase in neuron densities (8).…”

Section: Discussionmentioning

confidence: 99%

Mechanically-compliant intracortical implants reduce the neuroinflammatory response

et al. 2014

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Objective The mechanisms underlying intracortical microelectrode encapsulation and failure are not well understood. A leading hypothesis implicates the role of the mechanical mismatch between rigid implant materials and the much softer brain tissue. Previous work has established the benefits of compliant materials on reducing early neuroinflammatory events. However, recent studies established late onset of a disease-like neurodegenerative state. Approach In this study, we implanted mechanically-adaptive materials, which are initially rigid but become compliant after implantation, to investigate the long-term chronic neuroinflammatory response to compliant intracortical microelectrodes. Main results Three days after implantation, during the acute healing phase of the response, the tissue response to the compliant implants was statistically similar to that of chemically matched stiff implants with much higher rigidity. However, at two, eight, and sixteen weeks post-implantation in the rat cortex, the compliant implants demonstrated a significantly reduced neuroinflammatory response when compared to stiff reference materials. Chronically implanted compliant materials also exhibited a more stable blood-brain barrier than the stiff reference materials. Significance Overall, the data show strikingly that mechanically-compliant intracortical implants can reduce the neuroinflammatory response in comparison to stiffer systems.

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Section: Discussionmentioning

confidence: 99%

Mechanically-compliant intracortical implants reduce the neuroinflammatory response

et al. 2014

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“…One recent study examined the cytokines and soluble factors present around the implanted microelectrode arrays using laser capturing microdissection and gene expression analysis and found elevated levels of several pro-inflammatory and neurotoxic cytokines as well as tumor necrosis factor α (TNF α). Among these, upregulation of IL-1β mRNA is the most significant across all types of electrode designs tested [53]. …”

Section: Introductionmentioning

confidence: 99%

Effects of caspase-1 knockout on chronic neural recording quality and longevity: Insight into cellular and molecular mechanisms of the reactive tissue response

et al. 2014

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Chronic implantation of microelectrodes into the cortex has been shown to lead to inflammatory gliosis and neuronal loss in the microenvironment immediately surrounding the probe, a hypothesized cause of neural recording failure. Caspase-1 (aka Interleukin 1β converting enzyme) is known to play a key role in both inflammation and programmed cell death, particularly in stroke and neurodegenerative diseases. Caspase-1 knockout (KO) mice are resistant to apoptosis and these mice have preserved neurologic function by reducing ischemia-induced brain injury in stroke models. Local ischemic injury can occur following neural probe insertion and thus in this study we investigated the hypothesis that caspase-1 KO mice would have less ischemic injury surrounding the neural probe. In this study, caspase-1 KO mice were implanted with chronic single shank 3mm Michigan probes into V1m cortex. Electrophysiology recording showed significantly improved single-unit recording performance (yield and signal to noise ratio) of caspase-1 KO mice compared to wild type C57B6 (WT) mice over the course of up to 6 months for the majority of the depth. The higher yield is supported by the improved neuronal survival in the caspase-1 KO mice. Impedance fluctuates over time but appears to be steadier in the caspase-1 KO especially at longer time points, suggesting milder glia scarring. These findings show that caspase-1 is a promising target for pharmacologic interventions.

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“…Using microelectrodes, extracellular action potential (EAPs) and local field potentials (LFPs) can be recorded from multiple neurons across multiple cortical areas and layers. Even though penetrating microelectrodes can provide rich information from neurons, they can suffer from tissue damage during insertion [7]- [9], of various neural activity monitoring modalities [3]- [5]. For each modality shown, the lower boundary of the box specifies the spatial resolution indicated on the left axis, whereas the upper boundary specifies the spatial coverage on the right axis.…”

Section: Introductionmentioning

confidence: 99%

Silicon-Integrated High-Density Electrocortical Interfaces

Akinin

Park

et al. 2017

Proc. IEEE

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Relationship between intracortical electrode design and chronic recording function

Cited by 222 publications

References 70 publications

Mechanically-compliant intracortical implants reduce the neuroinflammatory response

Mechanically-compliant intracortical implants reduce the neuroinflammatory response

Effects of caspase-1 knockout on chronic neural recording quality and longevity: Insight into cellular and molecular mechanisms of the reactive tissue response

Silicon-Integrated High-Density Electrocortical Interfaces

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