Relationship between knee osteoarthritis and meniscal shape in observation of Japanese patients by using magnetic resonance imaging

Kawahara, Tsuneo; Sasho, Takahisa; Katsuragi, J.; Ohnishi, Takashi; Haneishi, Hideaki

doi:10.1186/s13018-017-0595-y

Cited by 17 publications

(13 citation statements)

References 19 publications

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“…This fact suggested that the change of MPH was less closely associated with OA-related knee structural abnormalities when compared with medial meniscal body height. A recent study by Kawahara et al reported a statistically significant association between MPH and cartilage lesions, which conflicted with our findings [24]. A possible reason was that their results did not adjust for the common confounders such as meniscal lesions.…”

Section: Discussioncontrasting

confidence: 99%

Meniscal anterior and posterior horn heights are associated with MRI-defined knee structural abnormalities in middle-aged and elderly patients with symptomatic knee osteoarthritis

Liu

2022

BMC Musculoskelet Disord

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Background Meniscal morphological changes are associated with knee OA. However, the correlation of meniscal height and OA-related knee structural abnormalities is still not well understood. The purpose of present study is to investigate whether and how meniscal anterior and posterior horn heights are associated with structural abnormalities in knees with symptomatic OA. Methods Our sample consisted of 106 patients (61 female, aged 40–73 years) with symptomatic knee OA. Kellgren-Lawrence system was used for radiographic evaluation. On sagittal sequence, medial meniscal posterior horn height (MPH), lateral meniscal anterior horn height (LAH) and lateral meniscal posterior horn height (LPH) were measured on the middle slice through the medial/lateral compartment. Knee structural abnormalities were assessed using the modified whole-organ magnetic resonance imaging score (WORMS). Associations between meniscal anterior and posterior horn heights and knee structural abnormalities were assessed using linear regression analysis. Results Higher MPH was significantly associated with higher WORMS score for medial meniscal anterior horn lesion (P = 0.016) but did not have a statistical association with other WORMS parameters. Increased LAH was statistically correlated with decreased WORMS scores for lateral compartmental cartilage lesions (P = 0.001–0.004) and lateral compartmental bone marrow edema patterns (BMEPs) (P = 0.021–0.027). Moreover, LPH was negatively associated with WORMS scores for lateral compartmental cartilage lesions (P = 0.007–0.041) and lateral compartmental BMEPs (P = 0.022–0.044). Additionally, higher MPH was statistically associated with lower trochlea cartilage WORMS score and higher LAH was significantly correlated with higher WORMS score for trochlea subarticular cysts. Conclusions Changes of LAH and LPH were inversely associated with the severity of lateral compartmental cartilage lesions and BMEPs, while higher MPH was only significantly correlated with more severe medial meniscal anterior horn lesions. Besides, MPH and LAH were also significantly associated with patellofemoral structural abnormalities. The present study provided novel information for understanding the role of meniscal morphological changes in knee OA, which would be helpful in identifying and evaluating knees with or at risks for OA.

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Section: Discussioncontrasting

confidence: 99%

Meniscal anterior and posterior horn heights are associated with MRI-defined knee structural abnormalities in middle-aged and elderly patients with symptomatic knee osteoarthritis

Liu

2022

BMC Musculoskelet Disord

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“…Two orthopaedic surgeons, with more than 10 years of experience in reading radiographs, who were blinded to the OA grade at radiography and clinical data, systematically evaluated the presence of MME as previously reported [24]. Briefly, the ends of the tibia and meniscal edge were manually identified from an MR coronal slice, and the horizontal distance between them was defined as the amount of meniscus extrusion.…”

Section: Mr Image Interpretationmentioning

confidence: 99%

Alignment factors affecting the medial meniscus extrusion increases the risk of osteoarthritis development

Goto

Okazaki

Akiyama

et al. 2018

Knee Surg Sports Traumatol Arthrosc

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Purpose Varus alignment is known as one of the major causes of medial compartment osteoarthritis (OA). Medial meniscus extrusion also plays a critical role in the in the development of OA. However, studies on the exact relationship between alignment parameters and medial meniscus extrusion are limited. Therefore, this study aimed to investigate this relationship in patients with knee OA. Methods Based on a retrospective analysis of the outpatient magnetic resonance imaging (MRI) database, 190 knees were identified to be examined using weight-bearing, whole-leg radiographs and MRIs within 3 months from the first consultation. Subsequently, various parameters of lower leg alignment were measured, which affected the knee varus in radiographs. Finally, a statistical analysis was performed to assess the relationships between the OA grade, distance of medial meniscus extrusion (MME), and alignment parameters; hip-knee-ankle angle (HKAA), percentage of mechanical axis (% MA), medial proximal tibial angle (MPTA), and joint line convergence angle (JLCA). The subjects were divided according to the presence or absence of MME (Group A: MME distance below 3 mm, Group B: MME distance 3 mm and above) to assess the differences in each alignment parameter correlated with MME distance between the groups. Results MME distance significantly increased with OA grade progression. HKAA, % MA, MPTA, and JLCA significantly correlated with medial meniscus extrusion distance (r = − 0.21, − 0.23, − 0.16, 0.3, respectively). Multiple regression analysis of each significant alignment combined with age, sex, and body mass index revealed that HKAA, % MA, MPTA, and JLCA were significant independent factors of MME distance (P = 0.008, 0.0026, 0.011, 0.0001, respectively). These significant findings were reinforced in group B. In contrast, the correlation between alignment parameters and medial meniscus extrusion distance was not significant in group A. Conclusion Varus alignment factors are related to MME distance especially in extruded meniscus knees, as the OA grade progressed. Therefore, the coexistence of varus alignment and MME can be the risk factors for OA progression. As the low MPTA was an independent alignment factor for generating varus alignment, patients with osteoarthritis of the knee with both, low MPTA and MME could be the appropriate candidates for early intervention by high tibial osteotomy. Level of evidence III.

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“…[17] , [7] , [18] Several MRI studies evaluating early OA changes in meniscal morphology and cartilage degeneration have been published. [19] , [20] To the best of our knowledge, there has been no study comparing MOAKS pre-and post-ACLR. In this study, early knee OA was easily quanti ed using MOAKS in ACL-injured knees .…”

Section: Discussionmentioning

confidence: 99%

Early Knee Osteoarthritis Changes Pre- And Post-Anterior Cruciate Ligament Reconstruction Assessed By the Semi-Quantitative MRI Osteoarthritis Knee Score (MOAKS) Case Series and Case-Control Study

Hamada

Sato

Watanabe

et al. 2021

Preprint

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Background: Semi-quantitative scoring of knee abnormalities on magnetic resonance imaging (MRI) can aid in the diagnosis of early stage knee osteoarthritis (OA). Injuries to the anterior cruciate ligament (ACL) and medial meniscus (MM) can contribute to the development of knee OA, but their relationship to its time of onset is unknown.Purpose: To analyze the factors contributing to early knee OA changes in ACL injured knees using MRI Osteoarthritis Knee Score (MOAKS). Methods: Thirty-four cases status post unilateral ACL reconstruction (ACLR) were included. Knee OA abnormalities were evaluated using MOAKS scores of MRIs performed pre- and post-ACLR. Using multiple linear regression analysis, the MOAKS scores of medial osteophytes, medial cartilage alteration, and patellofemoral cartilage alteration were determined as dependent variables. Age, the presence of a meniscal abnormality, the time from injury to ACLR, and body mass index (BMI) were determined as explanatory variables. MOAKS differences between knees with and without medial meniscus (MM) abnormality were tested for each variable using a 2-way repeated-measures analysis of variance with the factors of preoperative vs. postoperative status and MM abnormality. Results: In the pre-ACLR multiple linear regression analysis, the waiting period was significantly and positively associated with medial cartilage loss, Lateral femorotibial osteophytes, lateral cartilage loss. and BMI were positively associated with MM abnormalities. BMI and lateral meniscus (LM) abnormality were significantly associated with lateral cartilage loss. Age was significantly associated with medial osteophytes. Age and LM abnormality were significantly associated with lateral osteophytes. Age, BMI, and LM abnormality were significantly associated with patellofemoral osteophytes. Conclusion: We found early knee OA changes in most knees a mean of 28.2 ± 52.0 months after ACL injury. The time from injury to ACLR, BMI, and the presence of MM or LM abnormality in the ACL injured knee were associated with early knee OA changes. In the ACL injured knee with MM involvement, prompt ACLR may forestall the development of OA.

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Relationship between knee osteoarthritis and meniscal shape in observation of Japanese patients by using magnetic resonance imaging

Cited by 17 publications

References 19 publications

Meniscal anterior and posterior horn heights are associated with MRI-defined knee structural abnormalities in middle-aged and elderly patients with symptomatic knee osteoarthritis

Meniscal anterior and posterior horn heights are associated with MRI-defined knee structural abnormalities in middle-aged and elderly patients with symptomatic knee osteoarthritis

Alignment factors affecting the medial meniscus extrusion increases the risk of osteoarthritis development

Early Knee Osteoarthritis Changes Pre- And Post-Anterior Cruciate Ligament Reconstruction Assessed By the Semi-Quantitative MRI Osteoarthritis Knee Score (MOAKS) Case Series and Case-Control Study

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