Relationship between Left Yentricular Hypertrophy and Renal and Retinal Damage in Untreated Patients with Essential Hypertension.

Abstract

Weexamined the relationship between left ventricular hypertrophy (LVH) and renal and retinal damage in 174 untreated patients with essential hypertension. As an index of renal and retinal damage, we examined proteinuria and retinal vascular change. LVH was diagnosed according to left ventricular mass obtained from echocardiography. Of the hypertensive patients, 111 patients (64% ) had LVH. The incidences ofproteinuria and advanced retinal vascular change werehigher in patients with LVH than in those without LVH. In a multiple regression model, there wasa significant positive correlation between left ventricular mass and proteinuria, as well as diastolic blood pressure, sex, age and body mass index. In conclusion, proteinuria is related to elevated left ventricular mass in patients with essential hypertension.

Co-Relation of 24 Hours Proteinuria And Left Ventricular Hypertrophy in Hypertensive Patients.

“…(27) (28) In this study, the proteinuria is significant when associated retinopathy is present. Similar finding was seen in a study by S. Mokoto et al (25) They noted that the incidences of proteinuria and advanced retinal changes are significant.…”

“…(31) Pontremoli R et al (1998) concluded that microalbuminuria correlates with cardiovascular risk factors commonly associated with hypertension and is early marker of diffuse target organ damage in essential hypertension. (33)(34) (25) In this study, the high systolic and diastolic blood pressures are cause of left ventricular hypertrophy. The hypertension progressively causes left ventricular enlargement leading to systolic and diastolic dysfunction.…”

“…In study by G. Saitoh M et al (1998) noted that the incidences of proteinuria and advanced retinal vascular change were higher in patients with left ventricular hypertrophy than in those without left ventricular hypertrophy and concluded that proteinuria is related to elevated left ventricular mass in patients with essential hypertension. (25) According to estimates from Framingham study, Sheshadri et al concluded that blood pressure is significant determinant for life time risk of stroke. (26) It has been mentioned in studies by Wolf et al and Wachtell et al that the increasing levels of microalbuminuria were associated with increasing risks for heart attacks and strokes.…”

Retinal Microvasculature as a Model to Study the Manifestations of Hypertension

“…12 Retinal vascular changes assessed by standardized photographic methods were demonstrated to be associated with microalbuminuria and renal impairment in cross-sectional studies. [56][57][58] Such association was independent of BP, diabetes mellitus, and other risk factors and was also seen in persons without diabetes mellitus or hypertension. However, the findings from prospective studies are mixed.…”

Association between Left Ventricular Diastolic Dysfunction and Renal Hemodynamic Change in Patients with Treated Essential Hypertension

“…Echocardiographically determined LV mass and geometry have been associated with serum creatinine in patients with essential hypertension (19,20). LV mass has also been related to proteinuria and microalbuminuria in such patients (5,21,22). As for LV function, it has been reported that patients with renal insufficiency had both systolic and diastolic dysfunction (23).…”