Relationship Between Leptin and Neopterin Levels and Disease Activation Parameters in Patients With Rheumatoid Arthritis

Gulkesen, Arif; Akgol, Gurkan; Tuncer, Türkan; Kal, Gül Ayden; Telo, Selda; Poyraz, Ahmet Kursad; Kaya, Arzu

doi:10.5606/archrheumatol.2016.5893

Cited by 8 publications

(8 citation statements)

References 34 publications

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“…Ultimately, of 98 articles screened, 15 studies met the eligibility criteria. [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] The characteristics of the included studies are described in Table 1, and the study selection process is given in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…Twenty‐three studies have been selected for full‐text analysis; after securitization of them, eight studies were excluded due to the lack of sufficient data or similar results that were also reported in other publications. Ultimately, of 98 articles screened, 15 studies met the eligibility criteria 17–31 . The characteristics of the included studies are described in Table 1, and the study selection process is given in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

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Neopterin serum level does not reflect the disease activity in rheumatoid arthritis: A systematic review and meta‐analysis

et al. 2020

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Rheumatoid arthritis (RA) is a chronic autoimmune disease caused by established chronic inflammation. Neopterin levels have extensively been considered as a marker of immune activation during inflammation. In this study, we performed a systematic evaluation and meta-analysis to elucidate the overall relationship between neopterin concentration and RA disease activity. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, a systematic review was conducted using PubMed, Google Scholar, Web of Science, and Scopus from 2000 to August 2020. The Newcastle-Ottawa scale was used to assess the quality of eligible studies. The effect size (ES) and corresponding 95% confidence intervals (CIs) were calculated to evaluate this association. A total of 15 studies out of 98 met our inclusion criteria. The pooled analysis found that patients with RA had high level of neopterin; however, no statistically significant association was found between neopterin levels with high, intermediate, and low diseases activity score (DAS)-28 (ES =11.18, 95% CI: 6.02 to 16.34, and I 2 = 91.8%; and ES = 8.57, 95% CI: 6.41 to 10.37, and I 2 = 99.5%; and ES =12.45, 95% CI: −1.68 to 26.58, and I 2 = 99.0%, respectively). Our results indicated that the neopterin concentration does not seem to have any substantial impact on the RA disease activity.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Neopterin serum level does not reflect the disease activity in rheumatoid arthritis: A systematic review and meta‐analysis

et al. 2020

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“…Twenty studies were conducted in Asia ( 55 , 59 , 65 , 66 , 69 , 70 , 72 – 74 , 77 , 78 , 80 – 82 , 84 – 89 ), six in Europe ( 61 , 62 , 64 , 67 , 79 , 90 ), three in Africa ( 71 , 75 , 83 ), and the remaining one in America ( 76 ). Ten study groups included patients with RA ( 55 , 76 , 78 – 81 , 83 , 86 , 89 , 90 ), nine with SLE ( 55 , 65 , 70 , 71 , 75 – 77 , 82 , 84 ), eight with BD ( 59 , 65 , 66 , 69 , 72 – 74 , 87 ), three with IIM ( 62 , 88 ), two with pSS ( 64 , 67 ), one with SSc ( 61 ), and one with AS ( 85 ). The analytical methods used for measuring neopterin included an enzyme-linked immunosorbent assay (ELISA) in 18 studies ( 61 , 64 – 67 , 69 – 71 , 74 – 76 , 78 , 79 , 81 , 85 , 86 ,...…”

Section: Resultsmentioning

confidence: 99%

“…Ten study groups included patients with RA ( 55 , 76 , 78 – 81 , 83 , 86 , 89 , 90 ), nine with SLE ( 55 , 65 , 70 , 71 , 75 – 77 , 82 , 84 ), eight with BD ( 59 , 65 , 66 , 69 , 72 – 74 , 87 ), three with IIM ( 62 , 88 ), two with pSS ( 64 , 67 ), one with SSc ( 61 ), and one with AS ( 85 ). The analytical methods used for measuring neopterin included an enzyme-linked immunosorbent assay (ELISA) in 18 studies ( 61 , 64 – 67 , 69 – 71 , 74 – 76 , 78 , 79 , 81 , 85 , 86 , 88 , 90 ), liquid chromatography with fluorimetric detection in 10 ( 55 , 72 , 73 , 77 , 80 , 82 – 84 , 87 , 89 ), and radioimmunoassay in two ( 59 , 62 ). Serum was analysed in 26 studies ( 55 , 59 , 61 , 62 , 64 – 67 , 69 – 74 , 76 – 78 , 81 …”

Section: Resultsmentioning

confidence: 99%

A systematic review and meta-analysis of neopterin in rheumatic diseases

Mangoni,

Zinellu

2023

Front. Immunol.

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IntroductionNovel biomarkers of inflammation and oxidative stress might enhance the early recognition, management, and clinical outcomes of patients with rheumatic diseases (RDs). We assessed the available evidence regarding the pathophysiological role of neopterin, the oxidation product of 7,8-dihydroneopterin, a pteridine generated in macrophages activated by interferon-γ, by conducting a systematic review and meta-analysis of studies reporting its concentrations in biological fluids in RD patients and healthy controls.MethodsWe searched electronic databases for relevant articles published between inception and 31 August 2023. The risk of bias and the certainty of evidence were assessed using the Joanna Briggs Institute Critical Appraisal Checklist and the Grades of Recommendation, Assessment, Development and Evaluation Working Group system, respectively.ResultsIn 37 studies, when compared to healthy controls, RD patients had significantly higher concentrations of neopterin both in plasma or serum (standard mean difference, SMD=1.31, 95% CI 1.01 to 1.61; p<0.001; moderate certainty of evidence) and in the urine (SMD=1.65, 95% CI 0.86 to 2.43, p<0.001; I2 = 94.2%, p<0.001; low certainty of evidence). The results were stable in sensitivity analysis. There were non-significant associations in meta-regression and subgroup analysis between the effect size and age, male to female ratio, year of publication, sample size, RD duration, C-reactive protein, erythrocyte sedimentation rate, specific type of RD, presence of connective tissue disease, analytical method used, or biological matrix investigated (plasma vs. serum). By contrast, the effect size was significantly associated with the geographical area in studies assessing serum or plasma and with the type of RD in studies assessing urine.DiscussionPending additional studies that also focus on early forms of disease, our systematic review and meta-analysis supports the proposition that neopterin, a biomarker of inflammation and oxidative stress, can be useful for the identification of RDs. (PROSPERO registration number: CRD42023450209).Systematic review registrationPROSPERO, identifier CRD42023450209

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“…RA patients have been divided in low, moderate and high disease activity according to DAS28 score. However, no significant differences have been observed according to disease activity stratification, inflammatory markers, BMI and radiologic progression, thus leptin is not an useful biomarker [42].…”

Section: Irisin and Leptinmentioning

confidence: 98%

Beneficial effects of physical activity in Rheumatoid Arthritis patients: focus on active biomolecules

Restuccia

Ficarra

Perani

et al. 2022

Preprint

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Physical activity (PA) has a fundamental role in subjects with rheumatoid arthritis (RA), in terms of motility, joint function, muscle wasting, BMI (body mass index), cardiovascular fitness (CRF), mental health, but also changes in bioactive molecules that might influence the disease activity and patient’s wellbeing. A systematic search of Pubmed and Google Scholar library was performed for clinical trials, randomized-controlled trials, and pilot studies published in the last 15 years. Studies using as adjunctive therapy aerobic exercise, high-intensity interval training (HIIT), and moderate training as yoga were included. The available papers shown that exercise programs improve joint’s mobility and flexibility and the overall health status, without differences regarding age, gender or disease activity. All these findings are supported by the modulatory role of exercise-induced cytokines as interleukin-6 (IL-6) and irisin, together with a reduction of inflammatory markers.

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Relationship Between Leptin and Neopterin Levels and Disease Activation Parameters in Patients With Rheumatoid Arthritis

Cited by 8 publications

References 34 publications

Neopterin serum level does not reflect the disease activity in rheumatoid arthritis: A systematic review and meta‐analysis

Neopterin serum level does not reflect the disease activity in rheumatoid arthritis: A systematic review and meta‐analysis

A systematic review and meta-analysis of neopterin in rheumatic diseases

Beneficial effects of physical activity in Rheumatoid Arthritis patients: focus on active biomolecules

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