Relationship between leukocytes recruitment and risk of rebleeding in patients with peptic ulcers

Sulaieva, Oksana; Deliy, Victoriia; Zharikov, S. O.

doi:10.1016/j.pathophys.2015.07.002

Cited by 6 publications

(2 citation statements)

References 30 publications

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“…Neutrophils could also be responsible for bleeding in the gastro-intestinal tract. Indeed, an increased number of macrophages and neutrophils is observed in the ulcer margin in patients with stomach ulcer that undergoes re-bleeding [158]. In UC, NLR correlates with disease severity calculated by a score comprising the extent of intestinal bleeding [159].…”

Section: Contribution Of Neutrophils To Ibd-associated Thrombo-embmentioning

confidence: 99%

The Dual Role of Neutrophils in Inflammatory Bowel Diseases

Wéra

Lancellotti

Oury

2016

JCM

239

189

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Inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis, are characterised by aberrant immunological responses leading to chronic inflammation without tissue regeneration. These two diseases are considered distinct entities, and there is some evidence that neutrophil behaviour, above all other aspects of immunity, clearly separate them. Neutrophils are the first immune cells recruited to the site of inflammation, and their action is crucial to limit invasion by microorganisms. Furthermore, they play an essential role in proper resolution of inflammation. When these processes are not tightly regulated, they can trigger positive feedback amplification loops that promote neutrophil activation, leading to significant tissue damage and evolution toward chronic disease. Defective chemotaxis, as observed in Crohn’s disease, can also contribute to the disease through impaired microbe elimination. In addition, through NET production, neutrophils may be involved in thrombo-embolic events frequently observed in IBD patients. While the role of neutrophils has been studied in different animal models of IBD for many years, their contribution to the pathogenesis of IBD remains poorly understood, and no molecules targeting neutrophils are used and validated for the treatment of these pathologies. Therefore, it is crucial to improve our understanding of their mode of action in these particular conditions in order to provide new therapeutic avenues for IBD.

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Section: Contribution Of Neutrophils To Ibd-associated Thrombo-embmentioning

confidence: 99%

The Dual Role of Neutrophils in Inflammatory Bowel Diseases

Wéra

Lancellotti

Oury

2016

JCM

239

189

View full text Add to dashboard Cite

show abstract

“…Evaluation of O 2 À release by polymorphonuclear leukocytes (PMNs). PMNs were isolated from the venous blood 16 of consenting healthy volunteers (20-35 years) by doublegradient Ficoll-Hypaque centrifugation and hypotonic lysis of contaminating red blood cells as previously described. 17 The cells were counted on a hemocytometer.…”

Section: 4mentioning

confidence: 99%