Relationship Between Loneliness and Proangiogenic Cytokines in Newly Diagnosed Tumors of Colon and Rectum

Nausheen, B.; Carr, Norman J.; Peveler, Robert; Moss‐Morris, Rona; Verrill, Clare; Robbins, Elizabeth; Nugent, Karen; Baker, Alexander M.; Judd, M.; Gidron, Yori

doi:10.1097/psy.0b013e3181f0bc1c

Cited by 48 publications

(37 citation statements)

References 36 publications

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“…VEGF expression in tumor specimens taken from chronically stressed mice was significantly higher compared to control mice further correlating psychosocial conditions with tumor biology [16]. In colon cancer patients, implicit loneliness measured on a validated questionnaire correlated with significantly higher levels of VEGF by immunohistochemistry assessment of tumor specimens [25]. High levels of circulating interleukin 6 (IL-6), a pro-inflammatory cytokine, in patients with ovarian cancer have been associated with poor survival and earlier disease progression [26], and research has shown that ovarian cancer patients with low levels of social attachment have significantly higher levels of IL-6 [27].…”

Section: Discussionmentioning

confidence: 93%

Survival advantage of marriage in uterine cancer patients contrasts poor outcome for widows: A Surveillance, Epidemiology and End Results study

Lowery

Stany

Phippen

et al. 2015

Gynecologic Oncology

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Section: Discussionmentioning

confidence: 93%

Survival advantage of marriage in uterine cancer patients contrasts poor outcome for widows: A Surveillance, Epidemiology and End Results study

Lowery

Stany

Phippen

et al. 2015

Gynecologic Oncology

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“…Further research on the mechanisms underlying this relationship showed that lack of social support (or high levels of subjective loneliness) can translate into psychosocial stress, which then alters the endocrine and immune systems (17). In conclusion, assisting social support with organizational support and establishment of some type of screening for psychological distress in patients may lead to better cancer-related outcomes.…”

Section: Discussionmentioning

confidence: 99%

Social support and quality of life in a group of cancer patients (Ankara, Turkey)*

Yılmaz¹,

Piyal²,

Akdur³

2017

Turk J Med Sci

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Introduction There were 14.1 million new cancer cases, 8.2 million cancer deaths, and 32.6 million people living with cancer (within 5 years of diagnosis) in 2012 worldwide (1). Cancer represents a tremendous burden on patients, families, and societies (2). Cancer is firmly at the forefront of the Turkish health agenda with a total cancer incidence of 269.7 in males and 173.3 in females per 100,000 world standard population (3,4).Treatment methods, symptom control, and the sustaining of physiological, psychological, and social wellbeing are some important issues that individuals with cancer must tackle. From the point of view of preventing and coping with physical and mental problems related to illness and treatment, positive health behaviors, improvement of self-care, strengthening of social support networks, and provision of counseling, information, and education are considered to be positive factors regarding quality of life and perceived social support. Social support is defined as the existence or availability of people who let individuals know that they care about, value, and love them. The link between social support and psychological well-being is well established (5), and much of the research conducted suggests a role for social support in a number of diseases (i.e. cardiovascular disorders, cancer, infectious diseases) (6). During a hard and complex illness like cancer, perceived support from social relationships is very important (7,8).This study aims to evaluate the perceived social support and quality of life measures of the participants with respect to demographic and illness-related characteristics. Materials and methodsThis descriptive study was carried out in the inpatient and outpatient chemotherapy and radiotherapy units of the medical oncology departments of three hospitals located in Ankara: Ankara University Faculty of Medicine's hospitals on two different campuses, Ibn-i Sina Hospital (902 beds) and Cebeci Research Hospital (1011 beds); and the Dr.Background/aim: Cancer has become an important public health challenge all around the world. Though the demographic and clinical features of cancer patients are well documented in Turkey, the establishment of social support networks has been somewhat neglected. The aim of the study was to assess cancer patients' perceived social support and quality of life characteristics.

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“…General psychometric properties of IAT methodology across applications are reviewed by Nosek et al (2007). The IAT-L has shown good internal consistency and predictive validity, having been associated with greater cardiovascular reactivity to stress in a nonclinical sample (Nausheen et al, 2007) and with higher angiogenic cytokine activity in colorectal cancer patients (Nausheen et al, 2010). …”

Section: Methodsmentioning

confidence: 99%

Implicit loneliness, emotion regulation, and depressive symptoms in breast cancer survivors

et al. 2016

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Among individuals coping with cancer, emotional approach coping—expressing and processing emotions following negative events— has been identified as a potentially adaptive form of emotion regulation. However, its mental health benefits may depend on social-cognitive factors and on how it is implemented. This study examined loneliness as a determinant of emotion regulation associations with depressive symptoms in women with breast cancer. Loneliness was examined as an implicit social-cognitive phenomenon (i.e., automatic views of oneself as lonely), and emotional expression and processing were examined as both explicit and implicit processes. Approximately 11 months after diagnosis, 390 women completed explicit measures of coping through cancer-related emotional expression and processing; an implicit measure of expression and processing (an essay-writing task submitted to linguistic analysis); and an implicit association test (IAT) measuring loneliness. Depressive symptoms were assessed three months later. Regardless of implicit loneliness, self-reported emotional expression (but not emotional processing) predicted fewer depressive symptoms, whereas implicit expression of negative emotion during essay-writing predicted more symptoms. Only among women high in implicit loneliness, less positive emotional expression and more causal processing during the writing task predicted more depressive symptoms. Results suggest that explicit and implicit breast cancer-related emotion regulation have distinct relations with depressive symptoms, and implicit loneliness moderates effects of implicit emotional approach. Findings support implicit processes as influential mechanisms of emotion regulation and suggest targets for intervention among breast cancer survivors.

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Relationship Between Loneliness and Proangiogenic Cytokines in Newly Diagnosed Tumors of Colon and Rectum

Abstract: The results of this study suggest VEGF to be an angiogenic mechanism through which loneliness may lead to worse cancer-related outcomes. Implications are discussed in terms of devising targeted psychosocial and immunotherapeutic interventions for cancer patients with low social support.

Cited by 48 publications

References 36 publications

Survival advantage of marriage in uterine cancer patients contrasts poor outcome for widows: A Surveillance, Epidemiology and End Results study

Survival advantage of marriage in uterine cancer patients contrasts poor outcome for widows: A Surveillance, Epidemiology and End Results study

Social support and quality of life in a group of cancer patients (Ankara, Turkey)*

Implicit loneliness, emotion regulation, and depressive symptoms in breast cancer survivors

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