Relationship Between Low Skeletal Muscle Mass and Arteriosclerosis in Western China: A Cross-Sectional Study

Abstract

Objectives: This study explored the prevalence and the correlation between low muscle mass and arteriosclerosis in different gender and age groups, to increase the attention paid to the risk factors of arteriosclerosis in the young and middle-aged population.Methods: This was an analytical, cross-sectional study. Data were obtained from healthy individuals recruited from the Health Management Center of W Hospital. The brachial-ankle pulse-wave velocity was used as an indicator of arteriosclerosis, and a bioelectrical impedance analysis was used to assess the body composition.Results: A total of 36,374 subjects (men, 58.4%; women, 41.6%; mean age, 43.74 ± 12.34 years [range, 18–80 years]) participated in this study. The prevalence of low skeletal muscle mass and arteriosclerosis was 17.7 and 53.1%, respectively, in all subjects. Low skeletal muscle mass was significantly associated with arteriosclerosis (OR: 1.435, 95% CI: 1.343–1.533, P < 0.001) in all subjects, and the association remained significant in young age (OR: 1.506, 95% CI: 1.353–1.678, P < 0.001), middle-age (OR: 1.329, 95% CI: 1.195–1.479, P < 0.001), and old age (OR: 1.676, 95% CI: 1.191–2.358, P = 0.003), and also significant in men (OR: 1.559, 95% CI: 1.396–1.740, P < 0.001) and women (OR: 1.266, 95% CI: 1.143–1.401, P < 0.001).Conclusions and Implications: Our results show that the prevalence of low muscle mass and arteriosclerosis is high in the general population, even among middle-aged people and young people, and confirmed that there is a significant independent association between low skeletal muscle mass and arteriosclerosis in all subjects and in different age and gender subgroups.

Association between N-Terminal Prohormone Brain Natriuretic Peptide and Decreased Skeletal Muscle Mass in a Healthy Adult Population: A Cross-Sectional Study

“…Loss of muscle mass has been demonstrated to be a significant public health issue, with an estimated 10% prevalence of individuals (both sexes) with decreased skeletal muscle mass worldwide [ 1 ]. Decrease in the skeletal muscle mass is generally associated with the aging process, and this age-related decline in skeletal muscle mass may begin as early as >30 years of age [ 2 ]. In addition, owing to decreased physical activity in the middle-aged adult population, decreased skeletal muscle mass has become an increasingly important issue in the relatively young adult population [ 3 ].…”

Association between pulse pressure and low muscle mass in Korean adults: A nationwide cross-sectional study

“…[30] Moreover, low skeletal muscle mass was significantly and independently associated with arteriosclerosis overall and in various age and both sex subgroups. [31] PP serves as an indicator of changes in arterial stiffness. [16,18] A high PP previously exhibited a positive correlation with coronary heart disease [13,14] and increased the risk of nephropathy.…”

Increased Carcinoembryonic Antigen (CEA) Level Is Highly Associated with Low Skeletal Muscle Mass in Asymptomatic Adults: A Population-Based Study

“…It is also found in younger individuals with reduced muscle activity, ongoing physiological and pathological processes, and systemic inflammation [ 8 , 9 ]. Generally, muscle mass decreases by 3–8% every 10 years after 30 years of age due to changes in body composition and unfavorable metabolic alterations [ 10 ]. Due to this pathophysiology, LMM is considered a part of the aging process, with an estimated prevalence from 7% to over 50% in older people worldwide [ 11 ].…”

“…Due to this pathophysiology, LMM is considered a part of the aging process, with an estimated prevalence from 7% to over 50% in older people worldwide [ 11 ]. However, its prevalence can be high even among middle-aged and young populations, suggesting that LMM is prevalent in the general population, regardless of age [ 10 ].…”