Relationship between MAO Inhibitory and Anticonvulsant Properties of Substituted Cinnamides

Three novel series of benzo[b]thiophene derivatives bearing various hydrazone, hydrazine and 1,3,4-oxadiazole moieties were synthesized as potential antidepressant agents. 22 Compounds were evaluated for their in vitro inhibitory effect on monoamine oxidase enzyme (MAO) type A. Several compounds inhibited MAO stronger than pargyline hydrochloride. Maximum inhibitions of 83% and 90% were observed with 1-benzyl-2-(3-chlorobenzo[b]thienyl-2-carbonyl)hydrazine (24) and 1-[2-(4-chlorophenyl)ethyl]-2-(3-chlorobenzo[b]thienyl-2- carbonyl)hydrazine (35), respectively.

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Novel Benzo[b]thienylhydrazine and 1,3,4‐Oxadiazole Derivatives as Potential Antidepressant Agents

Aboulwafa

El-Metwalli

1992

Archiv der Pharmazie

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Synthesis of 1‐(N‐piperidinoacetyl)‐4‐arylthiosemicarbazides as possible anticonvulsants

Misra

Parmar

Kishore

et al. 1979

Journal of Heterocyclic Chem

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Several 1‐(N‐piperidinoacetyl)‐4‐arylthiosemicarbazides were synthesized from N‐piperidinoacetyl hydrazide, which was obtained by the reaction of hydrazine hydrate with ethyl N‐piperidinoacetate. The anticonvulsant activity of these substituted thiosemicarbazides was reflected by their ability to provide 10–50% protection against pentylenetetrazol‐induced convulsions in mice. All substituted thiosemicarbazides (0.3 mM) inhibited in vitro monoamine oxidase activity of rat brain homogenates and provided 21–86% protection against hypoosmotic hemolysis at a final concentration of 0.1 mM.

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Substituted 3,4,5-Trimethoxybenzamides: Correlation between Inhibition of Pyruvic Acid Oxidation and Anticonvulsant Activity

Chaturvedi

Chaudhari

Parmar

1972

Journal of Pharmaceutical Sciences

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Relationship between MAO Inhibitory and Anticonvulsant Properties of Substituted Cinnamides

Cited by 9 publications

References 13 publications

Novel Benzo[b]thienylhydrazine and 1,3,4‐Oxadiazole Derivatives as Potential Antidepressant Agents

Novel Benzo[b]thienylhydrazine and 1,3,4‐Oxadiazole Derivatives as Potential Antidepressant Agents

Synthesis of 1‐(N‐piperidinoacetyl)‐4‐arylthiosemicarbazides as possible anticonvulsants

Substituted 3,4,5-Trimethoxybenzamides: Correlation between Inhibition of Pyruvic Acid Oxidation and Anticonvulsant Activity

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