Relationship Between Marijuana Use and Hospitalization for Acute Coronary Syndrome

Abstract

Background: Recreational marijuana use is rising, especially among young adults. The cardiovascular (CVD) effect of marijuana remains mostly unknown.Methods: This is a retrospective study of 14,490 patients admitted to our hospital between 2012 and 2014 who had urine toxicology done for various reasons. Patients with a primary diagnosis of acute coronary syndrome (ACS) were queried in both the marijuana-positive group (n = 59) and the marijuana-negative group (n = 195). The risks of having ACS were compared in both groups.Results: There was no difference in the risk of having ACS between the two groups in the population < 54 years of age (OR: 0.90, 95% CI: 0.67-1.20, p = 0.48). However, there was a significant difference in the risk of having ACS in the 18-36 age group (OR: 2.84, 95% CI: 1.14-7.07, p = 0.01). Multivariate analysis performed to adjust for the potential confounding effects of smoking and cocaine use showed that marijuana use (OR: 0.93, 95% CI: 0.68-1.25, p = 0.65) did not increase the likelihood of ACS for patients ≤ 54 years or for those in the 37-54 age group (OR: 1.11, 95% CI: 0.79-1.53, p = 0.50). However, among the 18-36 age bracket, marijuana use was independently associated with a higher risk of ACS (OR: 5.24, 95% CI: 1.84-16.93, p = 0.002). Conclusion:In younger patients (age 18-36 years), marijuana use is independently associated with a fivefold higher risk of ACS.

Cannabis and adverse cardiovascular events: A systematic review and meta-analysis of observational studies

“…Of the 20 included studies, a total of 183,410,651 patients were enrolled with the number of participants in each study ranging from 51 to 118,659,619 patients. [10] , [11] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] The median age was 42.4 years old (IQR: 37.4, 50.0). The proportion of males was 23.7%.…”

“…Ten studies with a total of 64,602,083 patients reported acute MI, which occurred in 144,716 patients (0.22%) [10] , [11] , [24] , [26] , [30] , [31] , [34] , [35] , [38] , [40] . The pooled OR and rates of acute MI were shown in [ Fig.…”

“…Twenty studies with a total of 183,410,651 patients reported composite adverse CV events, which occurred in 313,703 patients (0.17%) [10] , [11] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] . The pooled OR and rates of composite adverse CV events were shown in [ Fig.…”

“…Thus, we used the random-effect model in our meta-analysis for this reason. Third, most of the included studies are cross-sectional and retrospective studies which include participants from the pre-existing cohort, national registry, and survey [10] , [11] , [24] , [26] , [27] , [28] , [29] , [30] , [31] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] . Hence, the data recorded in these studies were not pre-specified for cannabis use and could lead to information bias.…”

Efectos adversos del consumo de marihuana en el sistema cardiovascular

“…En el Ecuador se consumen 60 toneladas de droga al año, pero se reconoce que Antinarcóticos solo logra embargar 15 toneladas, de estas el 80% es marihuana. (el Comercio, 2018;Karki et al, 2022) En el III Estudio epidemiológico andino sobre consumo de drogas en la población universitaria de Ecuador, publicado en el año 2017 se pudo observar que el 26,9% de los estudiantes universitarios de Ecuador declararon haber usado marihuana alguna vez, con claras diferencias entre hombres y mujeres, 37,5% y 17,2% respectivamente (Oficina de las Naciones Unidas Contra la Droga y el Delito (UNODC) & Secretaría Técnica de Drogas del Ecuador (SETED, 2017). Sin embargo, en la actualidad no existen cifras verificables sobre la prevalencia del uso de marihuana en adultos jóvenes, no obstante, se conoce que su uso cada día es mayor debido a su fácil acceso, en Ecuador la Oficina de las Naciones Unidas Contra la Droga y el Delito (UNODC) en 2016 expuso que el 42,9% de los estudiantes declararon que les resultaría fácil conseguir marihuana: 46,2% de los hombres y 39,9% de las mujeres.…”