Relationship between Matrix Metalloproteinase-9 and Lifetime History of Suicidal Behavior in Remitted Patients with Bipolar I Disorder: A Cross-Sectional Pilot Study

Chandrasekaran, Vigneshvar; Subramanian, Karthick; Kattimani, Shivanand; Hanumanthappa, Nandheesha; Sarkar, Siddharth; Penchilaiya, Venkatalakshmi

doi:10.4103/ijpsym.ijpsym_320_19

Cited by 5 publications

(2 citation statements)

References 17 publications

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“…It suggested the role of biomarkers, especially in suicidality in bipolar disorder. [ 18 ] A study by Goyal et al [ 19 ] was done on a total of 120 subjects on inflammatory markers in the first episode and bipolar mania. The results of the study supported the inflammatory pathophysiology of mania as shown by significantly higher values of neutrophil counts and neutrophil/lymphocyte ratio (NLR) and significantly lower values of lymphocyte counts in both the first episode and bipolar mania compared to healthy controls.…”

Section: Resultsmentioning

confidence: 99%

Research on clinical aspects of bipolar disorder: A review of Indian studies

Narula,

Pal,

Reddy

et al. 2024

Indian Journal of Psychiatry

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Background: Bipolar disorder is one of the severe mental disorders that are associated with significant morbidity of the patients. Despite advancements in our understanding about the disorder, it remains a challenging proposition to treat bipolar disorder, largely since the prophylactic treatment of the disorder requires assessment of complex clinical algorithms. The revisions of the classificatory systems have also changed the conceptualization of the disorder. In this background, we conducted a review of the Indian studies conducted on the clinical aspects of bipolar disorder. Methods: A narrative review was conducted with focus on the literature published from India. The databases searched included PubMed, Scopus, and Google Scholar, and articles published over the last 15 years by Indian authors were included for this review. Results: In our review, we could access a substantial volume of research published from India. We could identify studies that catered to most of the relevant themes in bipolar disorder including epidemiology, etiology, comorbidities, stigma, disability, clinical course, cognitive profile, pathways to care, and recovery. Conclusion: The research trajectory was in line with the research conducted elsewhere in the world. However, certain dissimilarities in terms of focus could also be observed. The possible reason behind this deviation could be the difference in clinical need and unique challenges faced in the management and rehabilitation of patients in bipolar disorder in Indian scenario.

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Section: Resultsmentioning

confidence: 99%

Research on clinical aspects of bipolar disorder: A review of Indian studies

Narula,

Pal,

Reddy

et al. 2024

Indian Journal of Psychiatry

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“…In their study, Bobi'nska et al [106] investigate the presence of MMPs (MMP-9, MMP-2, and MMP-7) and TIMP-2 in the blood of people experiencing depression. A pilot study conducted by Chandrasekaran et al [107] demonstrated, as its main finding, elevated serum levels of MMP-9 in patients diagnosed with bipolar disorder and a significant duration of suicidal thoughts.…”

Section: The Inflammatory Function Of Matrix Metalloproteinases In Hu...mentioning

confidence: 94%

Metalloproteinases as Biomarkers and Sociomarkers in Human Health and Disease

Costa,

Scalise,

Ielapi

et al. 2024

Biomolecules

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Metalloproteinases (MPs) are zinc-dependent enzymes with proteolytic activity and a variety of functions in the pathophysiology of human diseases. The main objectives of this review are to analyze a specific family of MPs, the matrix metalloproteinases (MMPs), in the most common chronic and complex diseases that affect patients’ social lives and to better understand the nature of the associations between MMPs and the psychosocial environment. In accordance with the PRISMA extension for a scoping review, an examination was carried out. A collection of 24 studies was analyzed, focusing on the molecular mechanisms of MMP and their connection to the manifestation of social aspects in human disease. The complexity of the relationship between MMP and social problems is presented via an interdisciplinary approach based on complexity paradigm as a new approach for conceptualizing knowledge in health research. Finally, two implications emerge from the study: first, the psychosocial states of individuals have a profound impact on their overall health and disease conditions, which implies the importance of adopting a holistic perspective on human well-being, encompassing both physical and psychosocial aspects. Second, the use of MPs as biomarkers may provide physicians with valuable tools for a better understanding of disease when used in conjunction with “sociomarkers” to develop mathematical predictive models.

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