Relationship Between Mean Platelet Volume and Pulmonary Embolism in Patients With Deep Vein Thrombosis

Icli, Atilla; Aksoy, Fatih; Türker, Yasin; Uysal, Bayram Ali; Alpay, Mehmet Fatih; Doğan, Abdullah; Nar, Gökay; Varol, Ercan

doi:10.1016/j.hlc.2015.04.170

Cited by 27 publications

(18 citation statements)

References 33 publications

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“…15,16 It has been reported to be a risk indicator for predicting the possibility of PTE in patients with unprovoked DVT. 16,17 Considering the presence of hypercoagulable state in venous thromboembolism and acute PTE and purported pro-thrombotic properties of platelets with higher MPV, it is expected to see a correlation between high MPV and clinical outcomes in this specific disease. Several studies have explored and demonstrated its diagnostic value in diagnosing acute PTE among the suspected patients.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of platelet indices in patients with acute pulmonary thromboembolism

Ghaffari

Parvizian

Pourafkari

et al. 2020

J Cardiovasc Thorac Res

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Introduction: Given the role of platelets in thrombus formation, markers of platelet activation may be able to predict outcomes in patients with acute pulmonary thromboembolism (PTE). Methods: In a prospective cohort study, 492 patients with acute PTE were enrolled. Patients were evaluated for platelet indices including mean platelet volume (MPV), platelet distribution width (PDW), and platelet-lymphocyte-ratio (PLR), as well as for the simplified Pulmonary Embolism Severity Index (PESI) risk score. The primary endpoint was in-hospital all-cause mortality. Major adverse cardiopulmonary events (MACPE, composite of mortality, thrombolysis, mechanical ventilation and surgical embolectomy during index hospitalization) and all-cause death during follow-up were secondary endpoints. Results: MPV, PDW and PLR were 9.9±1.0 fl, 13.5±6.1%, and 14.7±14.5, respectively, in the total cohort. Whilst MPV was higher in those with adverse events (10.1±1.0 vs 9.9±1.0 fl; P = 0.019), PDW and PLR were not different between two groups. MPV with a cut-off point of 9.85 fl had a sensitivity of 81% and a specificity of 50% in predicting in-hospital mortality, but it had lower performance in predicting MACPE (Area under the curve: AUC 0.58; 95%CI 0.52-0.63) or long-term mortality (AUC 0.54; 95% CI 0.47-0.61). The AUC for all these three markers were lower than the AUC calculated for the simplified PESI score (0.80; 0.71-0.88). Conclusion: Platelet indices had only fair-to-good predictive performance in predicting in-hospital all-cause death. Established PTE risk scoring models such as simplified PESI outperform these indices in predicting adverse outcomes. Article info TUOMS P R E S SPlatelets indicies in acute pulmonary thromboembolism

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Section: Discussionmentioning

confidence: 99%

Prognostic value of platelet indices in patients with acute pulmonary thromboembolism

Ghaffari

Parvizian

Pourafkari

et al. 2020

J Cardiovasc Thorac Res

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“…Upon reviewing the studies that examine the role of MPV in acute pulmonary embolism, it was observed that İcli et al. determined an association of MPV with APE in the study carried out on patients with deep vein thrombosis . Similarly, Talay et al.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic validity of hematologic parameters in evaluation of massive pulmonary embolism

Ateş

Kundi

et al. 2016

J Clin Lab Anal

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“…Few studies have been done about inflammatory factors in correlation to DVT and PE. These studies show clear correlation between some inflammatory factors as red blood cell distribution width (RDW), mean platelet volume (MPV), P‐selectin, E–selectin, and DVT …”

Section: Introductionmentioning

confidence: 98%

The role of neutrophil‐lymphocyte ratio, and mean platelet volume in detecting patients with acute venous thromboembolism

Farah

Nseir

Kagansky

et al. 2019

Clinical Laboratory Analysis

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Background: Acute venous thromboembolism (VTE) refers to deep venous thrombosis (DVT) of the extremities or pulmonary embolism (PE), or to both. Reliable imaging is not always available making a serologic diagnosis, or biomarker, highly desirable. Objective: This study aimed to examine the role of neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and mean platelet volume (MPV) in detection patients with acute VTE. How to cite this article: Farah R, Nseir W, Kagansky D, Khamisy-farah R. The role of neutrophil-lymphocyte ratio, and mean platelet volume in detecting patients with acute venous thromboembolism.

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Relationship Between Mean Platelet Volume and Pulmonary Embolism in Patients With Deep Vein Thrombosis

Cited by 27 publications

References 33 publications

Prognostic value of platelet indices in patients with acute pulmonary thromboembolism

Prognostic value of platelet indices in patients with acute pulmonary thromboembolism

Diagnostic validity of hematologic parameters in evaluation of massive pulmonary embolism

The role of neutrophil‐lymphocyte ratio, and mean platelet volume in detecting patients with acute venous thromboembolism

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