Relationship between meiotic spindle characteristics in human oocytes and the timing of the first zygotic cleavage after intracytoplasmic sperm injection

Tomari, Hiroyuki; Honjou, K.; Nagata, Y.; Horiuchi, Toshitaka

doi:10.1007/s10815-011-9634-5

Cited by 25 publications

(22 citation statements)

References 31 publications

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“…Physical characteristics of the oocyte variably linked with oocyte development include perivitelline space size (174,175), GV location (176), smooth endoplasmic reticulum aggregation (175,(177)(178)(179)(180)(181), zona pellucida birefringence (182)(183)(184), and meiotic spindle formation (185)(186)(187). These morphological features of the oocyte have yet to become clinically useful in reliably predicting oocyte competence.…”

Section: Polar Body Analysis and Oocyte Morphologymentioning

confidence: 99%

Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health

Dumesic

Meldrum

Katz‐Jaffe

et al. 2015

Fertility and Sterility

501

314

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Section: Polar Body Analysis and Oocyte Morphologymentioning

confidence: 99%

Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health

Dumesic

Meldrum

Katz‐Jaffe

et al. 2015

Fertility and Sterility

501

314

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“…Meiosis progression, spindle morphology and chromosome alignment of MII oocytes are related to oocyte quality and developmental potential [Rama Raju et al, 2007;Ye et al, 2007;Tomari et al, 2011]. Abnormalities in spindle morphology and chromosome alignment at the metaphase plate have been found to lead to embryonic aneuploidy as a result of maternal factors such as advanced maternal age and obesity [Battaglia et al, 1996;Luzzo et al, 2012].…”

Section: Meiosis Progression and MII Spindle Abnormalitiesmentioning

confidence: 99%

“…The metaphase II (MII) spindle is often studied because of its role in the completion of meiosis, polar body extrusion and segregation of the chromosomes. An association has been found in mammalian models between spindle abnormalities and aneuploidy incidence which may result in pregnancy loss or genetic diseases [Rama Raju et al, 2007;Ye et al, 2007;Tomari et al, 2011].…”

mentioning

confidence: 99%

Bisphenol A Exposure during Oocyte Maturation in vitro Results in Spindle Abnormalities and Chromosome Misalignment in <b><i>Bos taurus</i></b>

Ferris

Favetta²,

King³

2015

Cytogenet Genome Res

128

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Bisphenol A (BPA) exposure in humans is widespread, and BPA has been detected in a variety of samples including follicular fluid. BPA levels have been found to negatively correlate with the developmental potential of oocytes in women undergoing in vitro fertilization and to induce meiotic abnormalities experimentally in human and mouse models. BPA may detrimentally affect oocyte maturation, and different concentrations of exposure can cause various outcomes. Because of the importance of oocyte maturation on developmental potential, disturbances during this time can significantly impact oocyte viability. Here, bovine oocytes were matured in vitro with and without BPA treatment of the media. The levels of BPA taken up by the oocytes were much lower than the initial exposure. Medium treatment with 30 ng/ml resulted in an average of 2.48 ng/ml BPA measured in mature oocytes. These oocytes exhibited decreased maturation and increased incidence of spindle abnormalities. Only 57.4% of oocytes exposed to 30 ng/ml BPA reached maturity compared to 72.4% of controls (p < 0.05). Mature oocytes following BPA exposure displayed increased abnormal spindle morphology (67.9%) and chromosome dispersal (60%) compared to all other groups analyzed (p < 0.05). Thus, exposure to BPA during in vitro oocyte maturation has the potential to decrease oocyte quality.

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“…A non-linear response to BPA doses on the incidence of MII oocytes with aligned chromosomes has also been determined (Machtinger et al 2013). The changes which have been recorded in the development of oocytes exposed to bisphenol may lead to disorders in the development of embryos, fetal loss or genetic disorders (Rama Raju et al 2007;Ye et al 2007;Tomari et al 2011). The result of maternal exposure to BPA may be the disruption of the entire oogenesis in the developing ovary (Susiarjo et al 2007).…”

Section: Influences Of Bpa On Reproduction Of Femalesmentioning

confidence: 99%

Bisphenol S instead of bisphenol A: a story of reproductive disruption by regretable substitution - a review

Žalmanová¹,

Hošková²,

Nevoral³

et al. 2016

Czech J. Anim. Sci.

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A range of substances that are released into the environment, foodstuffs and drinking water as a result of human activity were originally considered relatively harmless, and it was only later that their adverse effects were discovered. In general the use of such substances is currently restricted, and they are often replaced by other substances. This applies also in the case of a range of endocrine disruptors. These substances have the capacity to disturb the balance of physiological functions of the organism on the level of hormonal regulation, and their pleiotropic spectrum of effects is very difficult to predict. Endocrine disruptors include the currently intensively studied bisphenol A (BPA), a prevalent environmental pollutant and contaminant of both water and foodstuffs. BPA has a significantly negative impact on human health, particularly on the regulation mechanisms of reproduction, and influences fertility. The ever increasingly stringent restriction of the industrial production of BPA is leading to its replacement with analogues, primarily with bisphenol S (BPS), which is not subject to these restrictions and whose impacts on the regulation of reproduction have not yet been exhaustively studied. However, the limited number of studies at disposal indicates that BPS may be at least as harmful as BPA. There is therefore a potential danger that the replacement of BPA with BPS will become one of the cases of regrettable substitution, in which the newly used substances manifest similar or even worse negative effects than the substances which they have replaced. The objective of this review is to draw attention to ill-advised replacements of endocrine disruptors with substances whose effects are not yet tested, and which may represent the same risks for the environment, for the reproduction of males and females, and for human health as have been demonstrated in the case of the originally used substances.

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Relationship between meiotic spindle characteristics in human oocytes and the timing of the first zygotic cleavage after intracytoplasmic sperm injection

Cited by 25 publications

References 31 publications

Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health

Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health

Bisphenol A Exposure during Oocyte Maturation in vitro Results in Spindle Abnormalities and Chromosome Misalignment in <b><i>Bos taurus</i></b>

Bisphenol S instead of bisphenol A: a story of reproductive disruption by regretable substitution - a review

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