Relationship between Milk and Calcium Intake and Lipid Metabolism in Female Patients with Type 2 Diabetes

Kim, Jaehee; Hwang, Ji Hye; Kim, Ki Nam; Choi, Youngju; Chang, Namsoo; Huh, Kap-Bum

doi:10.3349/ymj.2013.54.3.626

Cited by 12 publications

(16 citation statements)

References 33 publications

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“…[30] Even though estrogen has the ability to inhibit hepatic lipase activity, it is our belief that the overall net effect favors progestin in the regulation of HDL-c in users of OCP. This observation is slightly different from that reported by Kim et al [25] They observed that in patients with diabetes mellitus, calcium was protective against decreasing HDL-c levels without elevating total cholesterol levels. The proposed mechanisms by which total calcium affects lipid metabolism are that calcium interferes with lipid absorption in the gut since it can bound to fatty acids and bile salts hydrolase.…”

Section: Discussioncontrasting

confidence: 99%

“…[15] While HDL-c increasing effect of calcium may be through a reduction in the activity of plasma cholesteryl ester transport protein (CETP). [25] We observed a significant association between measured lipoproteins except HDL-c and serum total calcium in OCP users. A subgroup of women OCP users with calcium levels of 2.0-2.05 mmol/L had the lowest concentrations of total lipids and lipoproteins, while those with higher total calcium levels (2.06-2.3 mmol/L) had the highest concentrations of the measured lipids.…”

Section: Discussionmentioning

confidence: 56%

“…Calcium has been reported to modulate lipid metabolism in both experimental animals and human studies. [25] Cobb et al [36] observed that OCP use may be detrimental to bone health in exercising women with normal menstrual cycles. Studies have also shown that physically active women on low-dose OCP had reduced bone mineral density (BMD) compared with physically active women who do not use OCP.…”

Section: Discussionmentioning

confidence: 99%

“…This active form of vitamin D regulates serum calcium levels by increasing calcium absorption from diet in the intestine and tubular re-absorption of calcium in the kidney. [15,25] A large Swedish health screening survey reported that changes in calcium metabolism, even within the physiological range, were related to increased blood pressure, impaired glucose tolerance and dyslipidaemia. [44] The increased serum total calcium levels in some subjects on low-dose OCP may be due to increased intestinal absorption, renal absorption, increased skeletal resorption or a combination of these factors since these activities are mediated by parathyroid hormone (PTH).…”

Section: Discussionmentioning

confidence: 99%

“…[24] Subjects with calcium intake above the estimated average requirement (EAR) exhibited significantly greater serum high-density lipoprotein cholesterol (HDL-c) levels than those with a calcium intake below EAR. [25] It was suggested that diabetes mellitus and CVDs are linked by a common defect of divalent cation metabolism including calcium. [26] Epidemiological evidence shows link between abnormality of lipid profile and variations in calcium levels.…”

Section: Introductionmentioning

confidence: 99%

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Serum calcium level is associated with lipids in young Nigerian women using low-dose oral contraceptive pills

Emokpae

Uadia

2014

J Basic Clin Reprod Sci

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Background: The formulation of low-dose oral contraceptive pill (OCP) has not been able to completely eliminate the cardiovascular risks associated with its use. Studies have associated serum calcium with metabolic syndrome, high blood pressure and lipids in the general population. Aim: To examine the association of serum total calcium with lipids levels and blood pressure in young Nigerian women who use OCP. Subjects and Methods: Fasting serum triglyceride, total cholesterol, high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), very low-density lipoprotein cholesterol (VLDL-c), total lipids and total calcium were assayed in 160 young women (110 OCP users and 50 controls) using colorimetric methods. Body mass index (BMI) and blood pressure were also measured. Results: Serum triglyceride (1.19(0.01) vs 0.94(0.02), total cholesterol (4.08(0.06) vs 3.52 (0.05), LDL-c (1.79(0.04) vs 1.24 (0.02), VLDL-c (0.25(0.02) vs 0.18(0.03), total lipids (7.55(0.2) vs 6.26(0.2), total calcium (2.25(0.01) vs 2.06(0.03), systolic (108.9(0.9) vs 103.1(0.9) and diastolic (67.7(0.7) vs 65.0(0.5) blood pressures were significantly higher (P < 0.001) in OCP users than non-users. Conversely, HDL-c levels in OCP users were lower (1.77(0.08) vs 1.84(0.02); P = 0.30) compared with non-users. Serum calcium positively correlated with blood pressure and lipid parameters except HDL-c in women OCP users. Women on OCP who had lower serum total calcium levels had statistically significant lower lipid parameters while those women on OCP who had higher serum calcium levels had significantly higher lipid parameters. The BMI of both study population and control was not significantly different. Conclusion: Low-dose OCPs induce increased levels of serum lipids, calcium and blood pressures. Serum total calcium level was positively associated with blood pressure, measured lipid parameters except HDL-c in women on OCP. These data suggest that serum calcium may have some influences on lipids and blood pressure in subjects who use OCP irrespective of their BMI.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Serum calcium level is associated with lipids in young Nigerian women using low-dose oral contraceptive pills

Emokpae

Uadia

2014

J Basic Clin Reprod Sci

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Genome-Wide Interaction Study of Dietary Intake and Colorectal Cancer Risk in the UK Biobank

Hoang,

Cho,

Choi

et al. 2024

JAMA Netw Open

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ImportanceCandidate gene analysis approaches have shown that colorectal cancer (CRC) risk attributable to diet may differ according to genotype. A genome-wide approach further allows for the exploration of underlying pathways for associations between diet and CRC risk across the genome.ObjectivesTo identify genetic variants that modify diet-CRC associations and to further explore the underlying pathways in the cause of CRC.Design, Setting, and ParticipantsThis nested case-control study used data on White British participants from the prospective cohort UK Biobank. Participants were recruited between March 13, 2006, and October 1, 2010, and data were censored June 25, 2021.ExposuresThe average frequency intake of 11 dietary factors in the year preceding baseline was obtained via a touchscreen questionnaire. After quality control for more than 93 million variants of imputed genetic data, 4 122 345 variants remained.Main Outcomes and MeasuresColorectal cancer cases were identified according to the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision. Genome-wide interaction analysis was performed to test interactions between dietary factors and variants using a conditional logistic regression model. Summary statistics of interactions at the variant level were used to calculate empirical P values for interactions at gene and gene-set levels in gene-based and gene-set enrichment analyses.ResultsA total of 4686 participants with CRC (mean [SD] age, 60.7 [6.6] years; 2707 men [57.8%]) received a new diagnosis during a median of 12.4 years (IQR, 11.6-13.1 years) of follow-up. Once a case was detected, 3 matched controls were identified, for a total of 14 058 controls (mean [SD] age, 60.4 [6.6] years; 8121 men [57.8%]). A total of 324 variants were identified that interacted with diet consumption at the suggestive threshold (P &lt; 1 × 10−5). In gene-based analysis, aggregation of multiple EPDR1 gene variants was found to interact with fish intake regarding CRC risk. Furthermore, gene-set enrichment analysis found that several sets of protein-coding genes, which were overrepresented with particular functions and pathways, interacted with the consumption of milk (ART), cheese (OR), tea (KRT), and alcohol (PRM and TNP).Conclusions and RelevanceIn this nested case-control study, the risk of CRC associated with fish intake was modified by multiple single-nucleotide polymorphisms of the EPDR1 gene. The findings further suggested possible functions and pathways that might link the consumption of milk, cheese, tea, and alcohol with CRC development.

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Influence of total sugar intake on metabolic blood markers at 8 years of age in the Childhood Obesity Project

et al. 2020

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Purpose We aimed to characterize the association of dietary sugar intake with blood lipids and glucose-related markers in childhood. Methods Data from the multicentric European Childhood Obesity Project Trial were used. Three-day weighed dietary records were obtained at 8 years of age along with serum concentrations of triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), glucose, and insulin. Total sugar intake comprised all mono-and disaccharides; different sugar sources were defined. Linear regression models were applied to investigate the cross-sectional association of total sugar intake with blood lipids and glucose-related markers with adjustment for total energy intake using the residual method. Results Data were available for 325 children. Children consumed on average 332 kcal (SD 110) and 21% (SD 6) of energy from total sugar. In an energy-adjusted model, an increase of 100 kcal from total sugar per day was significantly associated with a z score HDL-C decrease (− 0.14; 95% CI − 0.01, − 0.27; p value = 0.031). Concerning different food groups of total sugar intake, 100 kcal total sugar from sweetened beverages was negatively associated with z score HDL-C (− 1.67; 95% CI − 0.42, − 2.91; p value = 0.009), while total sugar from milk products was positively related to z score HDL-C (1.38, 95% CI 0.03, 2.72; p value = 0.045). None of the other blood lipids or glucose-related markers showed a significant relationship with total sugar intake. Conclusion Increasing dietary total sugar intake in children, especially from sweetened beverages, was associated with unfavorable effects on HDL-C, which might increase the long-term risk for dyslipidemia and cardiovascular disease. Clinical trial registry ClinicalTrials.gov Identifier: NCT00338689; Registered: June 19, 2006. URL: https ://clini caltr ials. gov/ct2/show/NCT00 33868 9?term=NCT00 33868 9&rank=1.

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Relationship between Milk and Calcium Intake and Lipid Metabolism in Female Patients with Type 2 Diabetes

Cited by 12 publications

References 33 publications

Serum calcium level is associated with lipids in young Nigerian women using low-dose oral contraceptive pills

Serum calcium level is associated with lipids in young Nigerian women using low-dose oral contraceptive pills

Genome-Wide Interaction Study of Dietary Intake and Colorectal Cancer Risk in the UK Biobank

Influence of total sugar intake on metabolic blood markers at 8 years of age in the Childhood Obesity Project

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