1988
DOI: 10.1016/0005-2760(88)90074-4
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Relationship between mitochondrial lipid peroxidation and α-tocopherol levels in the guineα-pig adrenal cortex

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Cited by 14 publications
(10 citation statements)
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“…Goss-Sampson and Muller [12] re ported increased glutathione peroxidase ac tivity on feeding vitamin E to rats. This vita min has been reported to protect the enzyme from the consequences of lipid peroxidation ii in adrenal cortex of guinea pigs [ 17], It is also likely that antioxidants induce modification in enzyme conformation without any cova lent change, hence increased enzyme activity. The present results are in agreement with the findings of Stewart and Boston [18] who re ported an increase in hepatic glutathione-Stransferase with BHA.…”
Section: Discussionmentioning
confidence: 85%
“…Goss-Sampson and Muller [12] re ported increased glutathione peroxidase ac tivity on feeding vitamin E to rats. This vita min has been reported to protect the enzyme from the consequences of lipid peroxidation ii in adrenal cortex of guinea pigs [ 17], It is also likely that antioxidants induce modification in enzyme conformation without any cova lent change, hence increased enzyme activity. The present results are in agreement with the findings of Stewart and Boston [18] who re ported an increase in hepatic glutathione-Stransferase with BHA.…”
Section: Discussionmentioning
confidence: 85%
“…Nonetheless, both in vitro observations (Staats & Colby 1987, Staats et al 1988b, 1989) and reports on the accumulation of lipofuscin in adrenals in vivo (Reichel 1968, Belloni et al 1987, Cheng et al 1996, Almeida et al 1998 suggest high levels of LP in the gland. As noted by others, the large amounts of polyunsaturated fatty acids found in adrenocortical membranes may predispose the adrenals to LP.…”
Section: Discussionmentioning
confidence: 99%
“…As noted above, the extensive deposition of lipofuscin granules in the adrenal cortex of humans and other species (Hornsby & Crivello 1983, Cheng et al 1996 is consistent with high levels of LP. Interestingly, adrenal accumulation of lipofuscin increases with aging and is greatest in the zona reticularis of the gland, the same zone that is most susceptible to LP in vitro (Staats & Colby 1987, Staats et al 1988b, 1989. The zona reticularis is also the major source of adrenal androgens, whose secretion decreases markedly with aging (Adams 1985, Parker 1991).…”
Section: Discussionmentioning
confidence: 99%
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