Relationship between moderate food restriction during pregnancy and Fe, Zn and Cu contents in maternal tissues and foetuses

Vaquero, M. Pilar; Navarro, M. L. Martínez

doi:10.1051/rnd:19960310

Cited by 4 publications

(1 citation statement)

References 17 publications

(21 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, the effects of anaemia on the fetal and neonatal kidney may be a mechanism common to a number of experimental models. In rats undernourished or fed a lowprotein diet during pregnancy, reductions in packed cell volume and total body Fe content are observed in the fetuses at day 21 of gestation (Vaquero & Navarro, 1996;Barone et al 1998). The findings of the present study highlight the importance of sufficient Fe levels, not only for normal renal development in utero, but also for the prevention of programming of hypertensive disease in later life.…”

Section: Discussionsupporting

confidence: 54%

Effect of maternal iron restriction during pregnancy on renal morphology in the adult rat offspring

et al. 2003

View full text Add to dashboard Cite

In rats, maternal anaemia during pregnancy causes hypertension in the adult offspring, although the mechanism is unknown. The present study investigated the renal morphology of adult rats born to mothers who were Fe-deficient during pregnancy. Rats were fed either a control (153 mg Fe/kg diet, n 7) or low-Fe (3 mg/kg diet, n 6) diet from 1 week before mating and throughout gestation. At delivery, the Fe-restricted (IR) mothers were anaemic; the IR pups were also anaemic and growth-retarded at 2 d of age. At 3 and 16 months, systolic blood pressure in the IR offspring (163 (SEM 4) and 151 (SEM 4) mmHg respectively, n 13) was greater than in control animals (145 (SEM 3) and 119 (SEM 4) mmHg respectively, n 15, P,0·05). At post mortem at 18 months, there was no difference in kidney weight between treatment groups, although relative kidney weight as a fraction of body weight in the IR offspring was greater than in control animals (P,0·05). Glomerular number was lower in the IR offspring (11·4 (SEM 1·1) per 4 mm 2 , n 13) compared with control rats (14·8 (SEM 0·7), n 15, P, 0·05). Maternal treatment had no effect on glomerular size, but overall, female rats had smaller and more numerous glomeruli per unit area than male rats. When all animals were considered, inverse relationships were observed between glomerular number and glomerular size (r2 0·73, n 28, P, 0·05), and glomerular number and systolic blood pressure at both 3 months (r2 0·42, n 28, P, 0·05) and 16 months of age (r2 0·64, n 28, P, 0·05). Therefore, in rats, maternal Fe restriction causes hypertension in the adult offspring that may be due, in part, to a deficit in nephron number.

show abstract

Section: Discussionsupporting

confidence: 54%