Relationship Between Monocyte-To-Lymphocyte Ratio and Coronary Plaque Vulnerability in Patients With Stable Angina

Fan, Zeyuan; Ji, Hanhua; Li, Yang; Jian, Xing; Li, Li; Liu, Tao

doi:10.2217/bmm-2017-0235

Cited by 34 publications

(40 citation statements)

References 31 publications

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“…The vulnerable plaque was identified by intravascular ultrasound, which cannot provide specific morphology characteristics of plaque, such as the thickness of plaque components. [ 27 ] Compared with the stable angina patients, ACS patients showed more intravascular ultrasound-derived TCFA in non-culprit lesions. In this study, the advantage of OCT in identifying vulnerable plaques was utilized to provide a direct link between MLR and the vulnerability of coronary atherosclerotic plaques in ACS patients, such as FCT and lipid core angle.…”

Section: Discussionmentioning

confidence: 99%

Relationship between monocyte/lymphocyte ratio and non-culprit plaque vulnerability in patients with acute coronary syndrome

et al. 2020

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The importance of monocyte/lymphocyte ratio (MLR) has been indicated in the initiation and progression of coronary artery disease. However, few previous researches demonstrated the relationship between MLR and plaque vulnerability. We aimed to investigate coronary non-culprit plaque vulnerability in patients with acute coronary syndrome (ACS) by optical coherence tomography (OCT). A total of 72 ACS patients who underwent coronary angiography and OCT test in Beijing Anzhen Hospital were included in this retrospective study. The plaque vulnerability and plaque morphology were assessed by OCT. The non-culprit plaque in high MLR group exhibited more vulnerable features, characterizing as thinner thickness of fibrous cap ( P = .013), greater maximum lipid core angle ( P = .010) and longer lipid plaque length ( P = .041). A prominently negative liner relation was found between MLR and thickness of fibrous cap (R = –0.225, P = .005). Meanwhile, the proportion of OCT-detected thin cap fibro-atheroma (TCFA) ( P = .014) and plaque rupture ( P = .017) were higher in high MLR group. Most importantly, multivariable logistic regression analysis showed MLR level was identified as an independent contributor to the presence of TCFA (OR:3.316, 95%: 1.448–7.593, P = .005). MLR could differentiate TCFA with a sensitivity of 60.0% and a specificity of 85.1%. Circulating MLR level has potential value in identifying the presence of vulnerable plaque in patients with ACS. MLR, as a non- invasive biomarker of inflammation, may be valuable in revealing plaque vulnerability.

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Section: Discussionmentioning

confidence: 99%

Relationship between monocyte/lymphocyte ratio and non-culprit plaque vulnerability in patients with acute coronary syndrome

et al. 2020

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“…Previous study demonstrated that MLR level was independently with TCFA in the patients with stable angina. The vulnerable plaque was identified by intravascular ultrasound (IVUS), which cannot provide specific morphology characteristics of plaque, such as the thickness of plaque components [27] . In this study, the advantage of OCT in identifying vulnerable plaques was utilized to provide a direct link between MLR and the vulnerability of coronary atherosclerotic plaques in ACS patients, such as FCT and lipid core angle.…”

Section: Discussionmentioning

confidence: 99%

Relationship between monocyte-to-lymphocyte ratio and coronary plaque vulnerability in patients with acute coronary syndrome: an optical coherence tomography study

Zhang

Zhao

Liu

et al. 2019

Preprint

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Background The importance of monocyte-to-lymphocyte ratio (MLR) has been indicated in the initiation and progression of coronary artery disease (CAD). However, few previous researches demonstrated the relationship between MLR and plaque vulnerability. We aimed to investigate coronary plaque vulnerability in patients with acute coronary syndrome (ACS) by optical coherence tomography (OCT). Methods A total of 72 ACS patients who underwent coronary angiography and OCT test in Beijing Anzhen hospital were included in this retrospective study. The plaque vulnerability and plaque morphology were assessed by OCT. Results The coronary plaque in high MLR group exhibited more vulnerable features, characterizing as thinner thickness of fibrous cap (FCT)(112.37 ± 60.24 vs 153.49 ± 73.29 μm, P = 0.013), greater maximum lipid core angle (167.36 ± 62.33 vs 138.79 ± 56.37°, P = 0.010) and longer lipid plaque length (6.34 ± 3.12 vs 4.50 ± 2.21mm, P = 0.041). A prominently negative liner relation was found between MLR and FCT (R = 0.225, P < 0.005). Meanwhile, the incidence of OCT-detected thin cap fibro-atheroma (TCFA) (44.7% vs 18.4%, P = 0.014) and plaque rupture (36.8% vs 13.2%, P = 0.017) were higher in high MLR group. Most importantly, multivariable logistic regression analysis showed MLR level was related to the presence of TCFA (OR:3.316，95%：1.448-7.593，P = 0.005). MLR level could differentiate TCFA with a sensitivity of 72.0% and a specificity of 66.1%. Conclusion Circulating MLR level has potential value in identifying the presence of vulnerable plaque in patients with ACS. MLR, as a non- invasive biomarker of inflammation, may be valuable in revealing plaque vulnerability. Key words Monocyte-to-lymphocyte ratio, Optical coherence tomography, Plaque vulnerability

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“…The monocyte-to-lymphocyte ratio (MLR) may be a biomarker of systemic in ammation to predict the severity and prognosis in malignant tumors and cardiovascular diseases. MLR is a low-cost biomarker that can be calculated simply from complete blood counts [14,15].…”

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confidence: 99%

“…The Patient Health Questionnaire (PHQ-9) was used to identify the depression in diabetes patients. It ranges from 0 to 27; and (0-4) is regarded as "none or minimum", (5-9) is "mild," (10)(11)(12)(13)(14) as "moderate," (15)(16)(17)(18)(19) is "moderately severe," and (20-27) is "severe." According to previous research, patients with PHQ-9 scores ≥ 10 are de ned as having clinically relevant depression (CRD).…”

Section: Assessment Of Depression and Diabetes Mellitusmentioning

confidence: 99%

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The monocyte-to-lymphocyte ratio and depression in diabetes patients

Zhou¹,

Wang²,

Li³

2020

Preprint

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Background: The purpose of this study was to determine the association between The monocyte-to-lymphocyte ratio (MLR) and depression with diabetes mellitus.Method: We examined data from the US National Health and Nutrition Examination Survey from 2009 to 2016. Cox proportional hazard models were used to calculate the associations between MLR and depression. For precise investigation of the relationship, we also plotted the smooth curve fit and generated a two-piecewise linear regression model using the penalized spline method.Result: We enrolled 2820 diabetes patients in the database. Diabetes patients who had high MLR tended to be young, female, obese, unmarried, and had low levels of education. For tertile analysis, the ORs and 95% CIs of clinically relevant depression in tertile analysis were 1.03 (0.91, 1.17) for the second group and 1.62 (1.44, 1.82) for the third group in the unadjusted model compared to the control group. A similar trend was observed for the adjusted model and the quartiles analysis. We found the inflection point of MLR was 2.7. There is a positive association between MLR and depression above the threshold, and no relationship was found when MLR was below the threshold in diabetes patients. Conclusion: There is a nonlinear relationship between MLR and depression in diabetes patients. High level of MLR more than the inflection point may add prognostic information for depression in diabetes patients.

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Relationship Between Monocyte-To-Lymphocyte Ratio and Coronary Plaque Vulnerability in Patients With Stable Angina

Abstract: Circulating MLR level has potential in identifying the vulnerable plaques in the setting of stable angina.

Cited by 34 publications

References 31 publications

Relationship between monocyte/lymphocyte ratio and non-culprit plaque vulnerability in patients with acute coronary syndrome

Relationship between monocyte/lymphocyte ratio and non-culprit plaque vulnerability in patients with acute coronary syndrome

Relationship between monocyte-to-lymphocyte ratio and coronary plaque vulnerability in patients with acute coronary syndrome: an optical coherence tomography study

The monocyte-to-lymphocyte ratio and depression in diabetes patients

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