Relationship between neonatal birth weight and maternal plasma amino acid profiles in lean and obese nondiabetic women and in type I diabetic pregnant women

Kalkhoff, Ronald K.; Kandaraki, Eleni; Morrow, Philip G.; Mitchell, Teresa H; Kelber, Sheryl T.; Borkowf, Harold I.

doi:10.1016/0026-0495(88)90101-1

Cited by 83 publications

(50 citation statements)

References 15 publications

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“…Therefore, raised maternal plasma concentrations as may occur in diabetes (30,31 ) would be likely to increase flux of substrate via the transporter opposing its apparent downregulation. Furthermore, there is a hint that syncytiotrophoblast plasma membrane surface area is increased in diabetes (32).…”

Section: Discussionmentioning

confidence: 99%

Altered activity of the system A amino acid transporter in microvillous membrane vesicles from placentas of macrosomic babies born to diabetic women.

Kuruvilla¹,

D'Souza²,

Glazier³

et al. 1994

J. Clin. Invest.

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Fetal macrosomia (FM) is a well-recognized complication of diabetic pregnancy but it is not known whether placental transport mechanisms are altered. We therefore studied the activity of the system A amino acid transporter, the system L amino acid transporter, and the Na+/H+ exchanger in microvillous membrane vesicles from placentas of macrosomic babies born to diabetic women (FM group), from placentas of appropriately grown babies born to diabetic women (appropriate for gestational age group) and from placentas of appropriately grown babies of normal women (control group). Sodium-dependent uptake of ["'C]-methylaminoisobutyric acid at 30 s (initial rate, a measure of system A activity) was 49% lower into FM vesicles than into control vesicles (P < 0.02); this effect was due to a decrease in Vmax of the transporter with no change in Km. There was no significant difference in system A activity between the appropriate for gestational age group and control or FM group. There was also no difference between system L transporter or Na+/H+ exchanger activity between the three groups. We conclude that the number of system A transporters per milligram of membrane protein in the placental microvillous membrane is selectively reduced in diabetic pregnancies associated with FM. (J. Clin. Invest. 1994.

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Section: Discussionmentioning

confidence: 99%

Altered activity of the system A amino acid transporter in microvillous membrane vesicles from placentas of macrosomic babies born to diabetic women.

Kuruvilla¹,

D'Souza²,

Glazier³

et al. 1994

J. Clin. Invest.

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“…This intrauterine hyperinsulinemic state results in increased fat tissue, liver glycogen content, and total body size [22, 23]. Other maternal fuels such as plasma amino acids and lipids are also thought to be contributors to overgrowth [24]. The metabolic processes that are responsible for the fetus pathophysiology of the diabetic mother have been elucidated in recent years and include maternal hyperglycemia, and increased levels of maternal, placental, and fetal insulin-like growth factors and leptin [4].…”

Section: Discussionmentioning

confidence: 99%

Macrosomic Newborns of Diabetic Mothers Are Associated with Increased Aortic Intima-Media Thickness and Lipid Concentrations

Akçakuş

Köklü²,

Baykan³

et al. 2006

Horm Res Paediatr

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Background/Aims: Exposure to diabetes in utero has been established as a significantrisk factor for some of components of metabolic syndrome. A few studies have examined relationship between the metabolic syndrome and echocardiographic left ventricular (LV) mass. We aimed to investigate relationship between abdominal aortic intima-media thickness (aIMT), LV mass and lipid profile in macrosomic newborns. Methods: Abdominal aIMT was measured in 30 macrosomic neonates of diabetic mothers (group A), 30 macrosomic neonates of healthy mothers (group B) and 30 healthy neonates (group C). Lipid profile and LV mass were determined. Result: Mean aIMT was significantly higher in groups A and B (0.489 ± 0.015, 0.466 ± 0.019 mm, respectively) than in controls (0.375 ± 0.024 mm). Weight-adjusted aIMT in group A was significantly higher than in groups B and C. Macrosomia was associated with increased lipid concentrations. Both LV mass indexed for BSA (body surface area) and birth weight measurements were significantly increased in group A compared with control. Conclusions: Macrosomic neonates of diabetic mothers have significant aIMT and LV mass indexed for BSA and birth weight with lipid alterations. It might play a role in the pathogenesis of atherosclerosis in adult life.

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“…In type 1 diabetes, amino acid concentrations in maternal plasma have been 342 compared to weight-matched, normoglycemic plasma, with differences becoming more 343 pronounced as pregnancy progresses [100]. In early pregnancy, only valine, lysine, and 344 citrulline were increased and in mid-gestation, serine, lysine, proline, and arginine levels 345 were higher but taurine levels were lower.…”

Section: Pre-existing Diabetes and Gdm 340 341mentioning

confidence: 99%

Review: Placental transport and metabolism of energy substrates in maternal obesity and diabetes

2017

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Please cite this article as: Gallo LA, Barrett HL, Nitert MD, Placental transport and metabolism of energy substrates in maternal obesity and diabetes, Placenta (2017), doi: 10.1016/j.placenta.2016.12.006. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

Relationship between neonatal birth weight and maternal plasma amino acid profiles in lean and obese nondiabetic women and in type I diabetic pregnant women

Cited by 83 publications

References 15 publications

Altered activity of the system A amino acid transporter in microvillous membrane vesicles from placentas of macrosomic babies born to diabetic women.

Altered activity of the system A amino acid transporter in microvillous membrane vesicles from placentas of macrosomic babies born to diabetic women.

Macrosomic Newborns of Diabetic Mothers Are Associated with Increased Aortic Intima-Media Thickness and Lipid Concentrations

Review: Placental transport and metabolism of energy substrates in maternal obesity and diabetes

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