Relationship Between Neutrophil-To-Lymphocyte Ratio and Plaque Components in Patients with Coronary Artery Disease: Virtual Histology-Intravascular Ultrasound Analysis

Choi, Yun Ha; Hong, Young Joon; Jeong, Myung Ho; Park, Soo Young; Cheong, Hae Chang; Cho, Jae-Young; Cho, Sang‐Cheol; Chang, Soo Y.; You, Jong Hyun; Song, Ji Eun; Lee, Ki Hong; Park, Keun-Ho; Sim, Doo Sun; Yoon, Nam Sik; Yoon, Hyun Ju; Kim, Kye Hun; Park, Hyung Wook; Kim, Ju Han; Ahn, Youngkeun; Cho, Jeong Gwan; Park, Jong Chun

doi:10.1016/j.amjcard.2013.01.151

Cited by 7 publications

(9 citation statements)

References 15 publications

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“…The increased total leucocyte counts may indicate an improved immune system, whilst the significantly lower estimates of neutrophil to lymphocyte ratio in the RJ group may reflect an improvement in the welfare status of dairy ewes. Other researchers reported that the lower neutrophil to lymphocyte ratio is associated with lower inflammatory indices in the body (Choi et al ., 2014). Further, previous authors have reported that beehive products increased the proliferation of leucocytes precursors of pluripotent stem cells in mice (Orsolić and Basić, 2005).…”

Section: Discussionmentioning

confidence: 99%

Effect of royal jelly on milk composition and blood biochemical parameters in lactating ewes

et al. 2019

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Use of antibiotics as feed additives has been reduced to avoid the hazard of drug residues, and consequently, the search for alternative natural additives has developed. Thus, the aim was to evaluate the influence of royal jelly (RJ) supplementation on milk composition, blood biochemical and antioxidant parameters of lactating ewes. Thirty-six Ossimi ewes were divided randomly into two groups (18 animals each). For a period of 4 weeks, the control group (CON) was fed a basal diet only, while the other group was fed the basal diet and supplemented with a single bolus of RJ (1000 mg/head). The RJ-supplemented ewes produced significantly higher milk protein, fat and total solids than the CON group. The RJ group had a significantly higher red blood cell count, haemoglobin content, haematocrit value and total leucocyte counts, but lower neutrophil to lymphocyte ratio when compared with the control treatment. The RJ group showed significantly higher concentrations of total antioxidant capacity, superoxide dismutase activity and glutathione in the serum compared with the control treatment. In conclusion, RJ supplements can improve the nutritive value of milk fat and the serum antioxidant activities in lactating ewes.

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Section: Discussionmentioning

confidence: 99%

Effect of royal jelly on milk composition and blood biochemical parameters in lactating ewes

et al. 2019

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“…[34][35][36] Patients with CAD with a high NLR have a potential for unstable plaques and inflammatory conditions. 37 Chang et al 38 performed a retrospective study, involving patients with femoropopliteal chronic total occlusion (CTO) after successful BMS implantation. The ISR group had an NLR higher than that of the non-ISR group.…”

Section: Parameters Of the Inflammatory Responsementioning

confidence: 99%

“…34 –36 Patients with CAD with a high NLR have a potential for unstable plaques and inflammatory conditions. 37…”

Section: Neutrophil/lymphocyte Ratiomentioning

confidence: 99%

Blood Cell Parameters and Predicting Coronary In-Stent Restenosis

2019

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Major advances in coronary interventional techniques and pharmacotherapy as well as the use of drug-eluting stents (DESs) have considerably reduced the risk of in-stent restenosis (ISR). However, ISR remains a major clinical challenge. Inflammation and platelet activation are important processes that underlie the pathophysiology of ISR. Parameters related to blood cells, entailing both cell count and morphology, are useful markers of the inflammatory response and platelet activation in clinical practice. Recent studies have highlighted several new combined or derived parameters related to blood cells that independently predict ISR after DES implantation. The neutrophil/lymphocyte ratio, an inflammatory marker, is regarded as a predictor of the risk of ISR and the stability of atherosclerotic plaques. The mean platelet volume, a widely used platelet activation parameter, has been shown to be a predictor of the risk of ISR and the efficacy of antiplatelet therapy. Other markers considered include the platelet/lymphocyte ratio, red blood cell distribution width, and platelet distribution width. This review provides an overview of these parameters that may help stratify the risk of coronary angiographic and clinical outcomes related to ISR.

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“…17 Patients having CAD with high NLR also have a higher possibility of having vulnerable plaque and greater inflammatory status, which can lead to acute coronary events. 18 In a study by Davies et al, 3.8% of patients had distal embolization during superficial femoral artery endoluminal interventions. 19 Balloon angioplasty may cause soft plaque to break into tiny particles and be flushed into a distal vessel.…”

Section: Discussionmentioning

confidence: 97%

The Relationship Between the Neutrophil-Lymphocyte Ratio and In-Stent Restenosis in Patients With Femoropopliteal Chronic Total Occlusions

et al. 2017

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We investigated the relationship between the neutrophil-lymphocyte ratio (NLR) and in-stent restenosis (ISR) in patients with femoropopliteal chronic total occlusions (CTOs). The study enrolled 180 patients who had undergone successful stenting treatment for femoropopliteal CTO. Patients with ISR were subsequently classified into 2 groups: early-ISR (within 1 year) and late-ISR (after 1 year). The clinical characteristics, angiographic data, and follow-up data were recorded. The baseline NLR was significantly higher in the early-ISR group than that in the non-ISR group [3.96(2.14) and 3.33(2.73), p = .04]. Receiver operating characteristic curve analysis suggested an optimum early ISR NLR cutoff point of 3.62, which showed a sensitivity and specificity of 73.4% and 80.4%, respectively (area under the curve: 0.707, 95% confidence interval: 0.603-0.792, P < .001). A subgroup analysis was performed based on the NLR value (<3.62 vs ≥3.62). In the NLR ≥3.62 subgroup, the incidence of early ISR was higher than that of late ISR ( P < .01). In the multivariate analysis, NLR ≥3.62 was independently and positively associated with a higher risk of early ISR. In conclusion, NLR is independently associated with early ISR after stent implantation in patients with femoropopliteal CTO.

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Relationship Between Neutrophil-To-Lymphocyte Ratio and Plaque Components in Patients with Coronary Artery Disease: Virtual Histology-Intravascular Ultrasound Analysis

Cited by 7 publications

References 15 publications

Effect of royal jelly on milk composition and blood biochemical parameters in lactating ewes

Effect of royal jelly on milk composition and blood biochemical parameters in lactating ewes

Blood Cell Parameters and Predicting Coronary In-Stent Restenosis

The Relationship Between the Neutrophil-Lymphocyte Ratio and In-Stent Restenosis in Patients With Femoropopliteal Chronic Total Occlusions

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