Relationship between newborn leptin levels and selected growth parameters

Sindiani, Amer; Obeidat, Rawan; Jbarah, Omar F.; Hazaimeh, Ethar

doi:10.1177/0300060519848613

Cited by 5 publications

(4 citation statements)

References 24 publications

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“…Only leptin levels were different between boys and girls, with girls having higher levels at age 3 months, but not at age 6 months. Similar results have been reported for leptin levels at age 1, 4 and 6 months in a small group of infants [32] and at birth [15,34].…”

Section: Discussionsupporting

confidence: 89%

“…These first 6 months after birth are considered a critical window for adiposity programming [9,10], ARH trajectories might be of importance in unraveling this early adiposity programming. ARH have been associated with later growth and adiposity, but most studies used cord blood [13][14][15][16][17][18] or newborn blood spots [19,20] to investigate ARH at birth or in specific groups (such as infants born premature or small-for-gestational age) [21,22]. However, data on ghrelin, PYY and leptin trajectories during early life in healthy term-born infants are very limited.…”

Section: Introductionmentioning

confidence: 99%

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Appetite-regulating hormone trajectories and relationships with fat mass development in term-born infants during the first 6 months of life

et al. 2021

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Background The first 6 months of life are a critical window for adiposity programming. Appetite-regulating hormones (ARH) are involved in food intake regulation and might, therefore, play a role in adiposity programming. Studies examining ARH in early life are limited. Purpose To investigate ghrelin, peptide YY (PYY) and leptin until 6 months and associations with fat mass percentage (FM%), infant feeding and human milk macronutrients. Procedures In 297 term-born infants (Sophia Pluto Cohort), ghrelin (acylated), PYY and leptin were determined at 3 and 6 months, with FM% measurement by PEAPOD. Exclusive breastfeeding (BF) was classified as BF ≥ 3 months. Human milk macronutrients were analyzed (MIRIS Human Milk Analyzer). Main findings Ghrelin increased from 3 to 6 months (p < 0.001), while PYY decreased (p < 0.001), resulting in increasing ghrelin/PYY ratio. Leptin decreased. Leptin at 3 months was higher in girls, other ARH were similar between sexes. Leptin at 3 and 6 months correlated with FM% at both ages(R ≥ 0.321, p ≤ 0.001) and gain in FM% from 1 to 6 months(R ≥ 0.204, p = 0.001). In BF infants, also ghrelin and ghrelin/PYY ratio correlated with this gain in FM%. Exclusively BF infants had lower ghrelin and higher PYY compared to formula fed infants at 3 months (p ≤ 0.039). ARH did not correlate with macronutrients. Conclusions Increasing ghrelin and decreasing PYY, thus increasing ghrelin/PYY ratio, suggests an increasing orexigenic drive until 6 months. ARH were different between BF and FF infants at 3 months, but did not correlate with human milk macronutrients. Ghrelin and leptin, but not PYY, correlated with more FM development during the first 6 months, suggesting that they might be involved in adiposity programming.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Appetite-regulating hormone trajectories and relationships with fat mass development in term-born infants during the first 6 months of life

et al. 2021

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“…The differences in cord blood concentrations between SGA and AGA infants, when exposed to hypertension, suggest a probable role of adipokines in fetal growth. There are reports of an association of adipokine levels and fetal growth in the literature [23,24]. Previous studies have shown that these hormones may have an effect on anthropometric growth parameters [23,25,26].…”

Section: Discussionmentioning

confidence: 99%

Pregnancy-induced hypertension, preterm birth, and cord blood adipokine levels

et al. 2020

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Maternal hypertension may alter physiological parameters, dysregulating the release of hormones such as adipokines, thus influencing the fetal growth course. This study investigated whether hypertensive disorders of pregnancy alter cord blood adipokine levels and correlate these with anthropometric parameters in preterm infants. This is a prospective cohort study with pregnant women < 37-week gestation with and without hypertension and their offspring. Cord blood leptin, adiponectin, and ghrelin were analyzed by LUMINEX®. These adipokines were compared between the groups exposed or not to gestational hypertension using non-parametric statistical tests. The hypertensive pregnancies had significantly higher cord blood leptin (1.00 (IQR 0.67-1.20 ng/mL)) and adiponectin (18.52 (IQR 17.52-25.13 μg/mL)) levels than those without hypertension (0.07 (IQR 0.06-0.08 ng/mL) and 8.13 (IQR 6.50-8.68 μg/mL), respectively, p < 0.0001). The adipokine levels were higher in AGA and SGA infants in the exposed group for both moderate and late preterm. SGA had significantly higher ghrelin levels than the AGA infants. Ghrelin levels were negatively correlated with birth weight (r = − 0.613, p < 0.001), birth length (r = − 0.510, p < 0.001), head circumference (− 0.346, p < 0.002), and gestational age (r = − 0.612, p < 0.001).Conclusions: Our findings demonstrate an increase in adipokine levels in the cord blood of preterm newborn infants exposed to maternal hypertension. What is Known:• Clinical evidence suggests that concentration of the serum adipokines may be affected by risk of hypertension in both adults and pregnant women.• Maternal profile as hypertension alters intrauterine environment and could affect the function of fetal metabolism, impairing fetal growth.

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“…The effects of intrauterine conditions on fetal development and cardiovascular risk were first examined in Barker’s Hypothesis and have been referred to as “fetal programming” [ 4 , 5 ]. To this end, correlations have been established between several adipokines levels in cord serum with parameters such as birthweight and gestational age [ 6 , 7 , 8 ], while little is known about newly emerging adipokines. Transforming growth factor beta-1 (TGFβ1) is one such adipokine, with few studies existing analyzing TGFβ1 levels in maternal and cord serum and their relationship with pregnancy outcomes and fetal growth.…”

Section: Introductionmentioning

confidence: 99%

Association between TGFβ1 Levels in Cord Blood and Weight Progress in the First Year of Life

et al. 2023

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Transforming growth factor beta-1 (TGFβ1) is an adipokine secreted from adipose tissue, placental tissue and immune cells with a role in cell proliferation, cell apoptosis and angiogenic proliferation. The role of TGFβ1 in pregnancy and child growth and the source of cord TGFβ1 are yet unknown. In this study, we sought to clarify the correlation of TGFβ1 levels with parameters of intrauterine growth and child growth during the first year of life, and to determine whether their source is primarily of fetal or maternal origin. Serum samples and anthropometric measurements were obtained from the LIFE Child cohort of 79 healthy mother–child pairs. Measurements were conducted using enzyme-linked immunosorbent assays. Statistical analyses including Mann–Whitney U-test, correlation analyses and linear regression analyses were performed using GraphPad Prism and R. TGFβ1 levels were significantly higher in cord than in maternal serum, suggesting a fetal origin. Multivariate regression analyses revealed strong positive associations between cord TGFβ1 levels at birth and child weight at U6. Furthermore, cord TGFβ1 was significantly correlated with child weight at approximately one year of age. An increase of 10,000 pg/mL in cord TGFβ1 concentrations at birth was associated with a higher body weight of 201 g at roughly one year of age when adjusted for sex.

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Relationship between newborn leptin levels and selected growth parameters

Cited by 5 publications

References 24 publications

Appetite-regulating hormone trajectories and relationships with fat mass development in term-born infants during the first 6 months of life

Appetite-regulating hormone trajectories and relationships with fat mass development in term-born infants during the first 6 months of life

Pregnancy-induced hypertension, preterm birth, and cord blood adipokine levels

Association between TGFβ1 Levels in Cord Blood and Weight Progress in the First Year of Life

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