Relationship Between Osteopontin Biochemical Parameters and BMD Status in Iraqi Postmenopausal Women with Osteoporosis

Abstract

Osteopontin hormone (OPN) is an extracellular matrix protein that is expressed in bone cells such as osteoblasts and osteoclasts and associated with bone turnover and bone mineral density (BMD) in postmenopausal women with osteoporosis.
 The aim of the study is to investigate serum levels of circulating OPN and its relationship with biochemical parameters and BMD in postmenopausal women with osteoporosis in Iraq. Serum samples from fifty postmenopausal women were selected from patients attending two educational hospitals in Baghdad, which are AL Wasity Educational Hospital and Baghdad Educational Hospital, during the period from November 2018 to March 2019. Twenty five postmenopausal healthy women were included as a control group. The studied subjects’ ages were in the range of 45-65 years. Dual energy X-ray absorptiometry (DEXA) was the device used to measure bone mineral density and diagnose osteoporosis in both groups. Blood samples were collected from each participant for measuring the serum levels of biochemical parameters (P, Alp, Ca, and OPN)
 The results of the demographic parameters showed a significant (P≤0.05) increase in mean values of age, menopause duration, and duration of productive life in the patients as compared to the control group. Also, strong positive correlations between patients and the control were recorded in age and duration of productive age, with a weak inverse correlation in menopause duration. While a significant (P≤0.05) decrease in the mean value of body mass index (BMI), BMD, and T-score as compared to the control. The correlation in BMI was weak significant positive while in the other two parameters it was weak significant inverse.
 The results of the present study showed non-significant differences (P ≥0.05) between the patients and control group for serum biochemical parameters.
 It was also noticed that there was a significant (P≤0.05) increase in the mean value of osteopontin hormone level in the patients as compared to the control, with a weak significant inverse (p≤0.05) correlation.

Impact of vitamin C level on osteoporosis of postmenopausal Iraqi women

“…World Health Organization (WHO) described the silent disease ;OP by the as a "progressive systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture (Shamsulddin et al, 2020). The intracellular OS increases osteoclast bone resorption while inhibiting osteoblast bone formation when associated with inflammatory cytokines (Lin et al, 2019).…”

“…Therefore, identifying individuals with increased risk of experiencing a fracture is crucial for early intervention and minimization of fracture risk (Cummings & Eastell, 2020).The goal of OP care is prevention of fractures and ultimately reduction in morbidity and mortality associated with it (Rajan et al, 2020). Overall, OP is three times more common in women than in men, because women have a lower peak bone mass, which is increased by the hormonal changes ( the state of an absence of menstrual periods for one year due to the inability of the ovary to release estrogen)causing bone loss and risk factors for OP (Shamsulddin et al, 2020). In Iraqi postmenopausal women, OP was linked to ageing, menopause, and x-ray osteopenia (Alosami et al, 2019).…”

Assessment of Some Bone Turnover in Chronic Kidney Disease Patients in Tikrit/Iraq

“…Teppala et al (2010) show that the serum Insulin-like growth factor decreased among CKD (6), while Nishi et al (2022) show the opposite (7). Shamsulddin et al (2020) show a significant increase in serum Osteopontin (OPN) among Iraqi CKD (8). Ameen and Ali, (2018) showed increased serum levels of Fibroblast growth factor-23 (FGF-23) among CKD (9).…”

Dental Plaque and Gingivitis in Relation to Knowledge and Attitude among Osteoporotic Menopausal Women in Baghdad City, Iraq

“…As a result, the bones could deteriorate, making them more brittle and prone to breaking. The incidence of osteoporosis and bone loss increases with age; in addition, lack of certain hormones, mainly estrogen in women and androgen in men, is the main contributor to osteoporosis (2)(3) . The dual energy X-ray absorptiometry (DEXA) scan is a device use for osteoporosis diagnosis and screening makes the Bone Mineral Density (BMD) test available for many patients (4) .…”