Relationship Between Oxygen Saturation and Umbilical Cord pH Immediately After Birth

Uslu, Sinan; Bülbül, Ali; Can, Emrah; Zubarioglu, Umut; Salihoğlu, Özgül; Nuhoğlu, Asiye

doi:10.1016/j.pedneo.2012.08.005

Cited by 8 publications

(4 citation statements)

References 39 publications

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“…The observations made on this preclinical model lead us to propose a physiopathological paradigm whereby PAIS derives from a triple risk combination: ( i ) a materno-fetal inflammation leading to focal intra-cranial arteritis affecting selectively arteries arising from the carotid tree [9,47]; ( ii ) a developmental window of susceptibility [22,48,49,50,51]; and ( iii ) a physiological perinatal pro-coagulatory state reinforced by the materno-fetal inflammatory response [3,4,52,53] (Figure 7). …”

Section: Discussionmentioning

confidence: 99%

Perinatal Arterial Ischemic Stroke Is Associated to Materno-Fetal Immune Activation and Intracranial Arteritis

Guiraut

Cauchon

Lepage

et al. 2016

IJMS

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The medium-size intra-cranial arteries arising from the carotid bifurcation are prone to perinatal arterial ischemic strokes (PAIS). PAIS’ physiopathology needs to be better understood to develop preventive and therapeutic interventions that are currently missing. We hypothesized that materno-fetal inflammation leads to a vasculitis affecting selectively the carotidian tree and promoting a focal thrombosis and subsequent stroke. Dams were injected with saline or lipopolysaccharide (LPS) from Escherichia coli. A prothrombotic stress was applied on LPS-exposed vs. saline (S)-exposed middle cerebral arteries (MCA). Immunolabeling detected the inflammatory markers of interest. In S-exposed newborn pups, a constitutive higher density of macrophages combined to higher expressions of tumor necrosis factor-α (TNF-α), and interleukin 1β (IL-1β) was observed within the wall of intra- vs. extra-cranial cervicocephalic arteries. LPS-induced maternal and placental inflammatory responses mediated by IL-1β, TNF-α and monocyte chemotactic protein 1 (MCP-1) were associated with: (i) increased density of pro-inflammatory macrophages (M1 phenotype); and (ii) pro-inflammatory orientation of the IL-1 system (IL-1β/IL-1 receptor antagonist (IL-1Ra) ratio) within the wall of LPS-, vs. S-exposed, intra-cranial arteries susceptible to PAIS. LPS plus photothrombosis, but not sole photothrombosis, triggered ischemic strokes and subsequent motor impairments. Based on these preclinical results, the combination of pro-thrombotic stress and selective intra-cranial arteritis arising from end gestational maternal immune activation seem to play a role in the pathophysiology of human PAIS.

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Section: Discussionmentioning

confidence: 99%

Perinatal Arterial Ischemic Stroke Is Associated to Materno-Fetal Immune Activation and Intracranial Arteritis

Guiraut

Cauchon

Lepage

et al. 2016

IJMS

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“…Low arterial SpO 2 at birth has been associated to low pH in umbilical blood. Readings below 60% or the development of an unstable baseline SaO 2 reading is related to hypoxia and acidosis 25 26. Kühnert et al 27 stated that when the arterial SpO 2 fell below 30%, it was highly predictive of a pH below 7.20 and evolving blood acidosis.…”

Section: Discussionmentioning

confidence: 99%

Elective caesarean delivery adversely affects preductal oxygen saturation during birth transition

Zanardo

Cengio

Parotto

et al. 2015

Arch Dis Child Fetal Neonatal Ed

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“…The pH value of the arterial umbilical cord blood, which represents an accurate, reproducible, and objective evaluation of oxygen deficiency during birth, was measured to one decimal place. Using the pH value of the umbilical cord blood is therefore recommended to evaluate the newborn outcome [36,37].…”

Section: Newborn Parametersmentioning

confidence: 99%

The Impact of Higher Than Recommended Gestational Weight Gain on Fetal Growth and Perinatal Risk Factors—The IOM Criteria Reconsidered

Kirchengast,

Fellner,

Haury

et al. 2024

IJERPH

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A too-high gestational weight gain, in combination with steadily increasing obesity rates among women of reproductive age, represents an enormous obstetrical problem, as obesity and high gestational weight gain are associated with enhanced fetal growth, low vital parameters, and increased cesarean section rates. This medical record-based study investigates the association patterns between too-low as well as too-high gestational weight gain, according to the 2009 Institute of Medicine (IOM) guidelines, and fetal growth, as well as birth mode and pregnancy outcome. The data of 11,755 singleton births that had taken place between 2010 and 2020 at the Public Clinic Donaustadt in Vienna, Austria, were analyzed. Birth weight, birth length, head circumference, APGAR scores, and pH values of the arterial umbilical cord blood described fetal growth as well as the vital parameters after birth. Gestational weight gain was classified as too low, recommended, or too high according to the different weight status categories of the IOM guidelines. Birth weight, birth length, and head circumference of the newborn were significantly increased (p < 0.001) among underweight, normal-weight, and overweight women who gained more weight than recommended. Among obese women, only birthweight was significantly (p < 0.001) higher among women who gained more weight than recommended. Furthermore, a too-high gestational weight gain was significantly associated with an increased risk of macrosomia and emergency cesarean sections among underweight, normal-weight, and overweight women, but not among obese ones. Obese and morbidly obese women experiencing excessive gestational weight gain showed no significantly increased risk of macrosomia or emergency cesarean section. However, among obese mothers, a too-low gestational weight gain reduced the risk of emergency cesarean sections significantly (p = 0.010). Consequently, the IOM recommendations for gestational weight gain fit only partly for pregnant women in Austria. In the case of obese and morbidly obese women, new guidelines for optimal pregnancy weight gain should be considered.

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Relationship Between Oxygen Saturation and Umbilical Cord pH Immediately After Birth

Abstract: Determination of umbilical arterial blood pH values, in addition to clinical findings and oxygen saturation measurements, might be helpful in deciding the concentration of oxygen and whether or not to continue oxygen supplementation in the delivery room.

Cited by 8 publications

References 39 publications

Perinatal Arterial Ischemic Stroke Is Associated to Materno-Fetal Immune Activation and Intracranial Arteritis

Perinatal Arterial Ischemic Stroke Is Associated to Materno-Fetal Immune Activation and Intracranial Arteritis

Elective caesarean delivery adversely affects preductal oxygen saturation during birth transition

The Impact of Higher Than Recommended Gestational Weight Gain on Fetal Growth and Perinatal Risk Factors—The IOM Criteria Reconsidered

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