Relationship between oxytocin receptor genotype and recognition of facial emotion.

Melchers, Martin; Montag, Christian; Markett, Sebastian; Reuter, Martin

doi:10.1037/a0033748

Cited by 38 publications

(34 citation statements)

References 94 publications

(114 reference statements)

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“…This result fits with previous findings showing enhanced social abilities in carriers of the TT-genotype in areas like trust (Reuter et al, 2009), blameworthiness ratings (Walter et al, 2012) or facial emotion recognition (Melchers et al, 2013) compared to carriers of the CC-genotype.…”

Section: Discussionsupporting

confidence: 92%

“…First of all, we examined a sample with an unequal gender distribution with much more female than male participants, which possibly shifted the observed task performance compared to a genderbalanced sample (compare Melchers et al, 2013). Nevertheless, we didn't find differences in IPT performance depending on gender, which reduces the relevance of the sex ratio in our sample.…”

Section: Discussionmentioning

confidence: 94%

“…Walter et al (2012) reported that carriers of the C-allele rate accidentally committed harm more blameworthy than noncarriers. Melchers et al (2013) were able to show better emotion-recognition abilities in carriers of the T-allele compared to noncarriers. Christ, Carlo, and Stoltenberg (2014) demonstrated higher empathic accuracy in carriers of the TT-genotype.…”

mentioning

confidence: 89%

“…Here, it is possible to investigate individual differences in the genetic makeup of the oxytocinergic system to better understand individual differences in social functioning (compare Melchers, Montag, Markett, & Reuter, 2013). Of special relevance is the gene coding for the oxytocin receptor (OXTR-gene), which has been a focus of research in the social neurosciences over the last years (Meyer-Lindenberg, Domes, Kirsch, & Heinrichs, 2011;Montag & Reuter, 2014).…”

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confidence: 99%

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The oxytocin receptor gene and social perception

Melchers

Montag

Felten

et al. 2015

Social Neuroscience

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Social perception is an important prerequisite for successful social interaction, because it helps to gain information about behaviors, thoughts, and feelings of interaction partners. Previous pharmacological studies have emphasized the relevance of the oxytocin system for social perception abilities, while knowledge on genetic contributions is still scarce. In the endeavor to fill this gap in the literature, the current study searches for associations between participants' social perception abilities as measured by the interpersonal perception task (IPT) and the rs2268498 polymorphism on the OXTR-gene, which has repeatedly been linked to processes relevant to social functioning. N = 105 healthy participants were experimentally tested with the IPT and genotyped for the rs2268498 polymorphism. T-allele carriers (TT and TC genotypes) exhibited significantly better performance in the IPT than carriers of the CC-genotype. This difference was also significant for the subscales measuring the strength of social bonding (kinship and intimacy). As in previous studies, T-allele carriers exhibited better performance in measures of social processing indicating that the rs2268498 polymorphism is an important candidate for understanding the genetic basis of social functioning.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 94%

mentioning

confidence: 89%

mentioning

confidence: 99%

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The oxytocin receptor gene and social perception

Melchers

Montag

Felten

et al. 2015

Social Neuroscience

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“…Does more oxytocin activation of the neocortex in the context of a rich social and sensory environment improve early perceptual skills? Newer gene association studies have identified sensory processing relationships with OXTR genotype in adults, including decoding speech in a noisy environment (Tops et al, 2011), sensitivity to infant cues (BakermansKranenburg and Van Ijzendoorn, 2008), and facial emotion processing (O'connell et al, 2012;Melchers et al, 2013). As described above, perception of 'animacy' was also recently associated with OXTR methylation status (Jack et al, 2012).…”

Section: Future Research Directionsmentioning

confidence: 94%

Developmental Perspectives on Oxytocin and Vasopressin

Hammock

2014

Neuropsychopharmacol

167

146

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The related neuropeptides oxytocin and vasopressin are involved in species-typical behavior, including social recognition behavior, maternal behavior, social bonding, communication, and aggression. A wealth of evidence from animal models demonstrates significant modulation of adult social behavior by both of these neuropeptides and their receptors. Over the last decade, there has been a flood of studies in humans also implicating a role for these neuropeptides in human social behavior. Despite popular assumptions that oxytocin is a molecule of social bonding in the infant brain, less mechanistic research emphasis has been placed on the potential role of these neuropeptides in the developmental emergence of the neural substrates of behavior. This review summarizes what is known and assumed about the developmental influence of these neuropeptides and outlines the important unanswered questions and testable hypotheses. There is tremendous translational need to understand the functions of these neuropeptides in mammalian experience-dependent development of the social brain. The activity of oxytocin and vasopressin during development should inform our understanding of individual, sex, and species differences in social behavior later in life.

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A functional polymorphism of the OXTR gene is associated with autistic traits in Caucasian and Asian populations

Montag

Sindermann

Melchers

et al. 2017

American J of Med Genetics Pt B

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There is increasing evidence for associations between polymorphisms of the oxytocin receptor (OXTR) gene and autism spectrum disorder, but to date no study has established links with autistic traits in healthy subjects and potential cultural differences. The present research firstly investigated associations between three widely studied OXTR SNPs and autistic and empathic traits (rs53576 (G/A); rs2254298 (G/A); rs2268498 (T/C)) in two independent studies on male and female Caucasian (n = 537) and Chinese students (n = 280). Autistic and empathic traits were measured in all subjects in the two independent groups using the Autism -Spectrum Quotient (AQ) and the Interpersonal Reactivity Index (IRI) respectively, together with their sub-scales. For both sites, genotyping of the OXTR SNPs was conducted on buccal swab samples using a Cobas Z 480 Light Cycler following automated DNA extraction. Associations at the genotype level with autism trait scores were found in Caucasian subjects for rs2268498 only, with TT carriers having the lowest AQ scores compared with those carrying at least one C-allele. This finding was independently replicated in the Chinese sample although a smaller proportion carried the C-allele compared with the Caucasian sample. Some minor associations were found between empathy trait scores and the three SNPs but were not consistent between the samples. These findings show for the first time that the rs2268498 SNP localized in the promoter flanking region of the OXTR gene is associated with autistic traits in different ethnic/cultural groups. This provides further support for the role of the OXTR gene in relation to autism.

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Relationship between oxytocin receptor genotype and recognition of facial emotion.

Cited by 38 publications

References 94 publications

The oxytocin receptor gene and social perception

The oxytocin receptor gene and social perception

Developmental Perspectives on Oxytocin and Vasopressin

A functional polymorphism of the OXTR gene is associated with autistic traits in Caucasian and Asian populations

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