Relationship between penile fracture and Peyronie's disease: a prospective study

Açıkgöz, Aydan; Gökçe, Erkan; Aşçı, Ramazan; Büyükalpelli, Recep; Yılmaz, Ahmet; Sarıkaya, Şaban

doi:10.1038/ijir.2011.24

Cited by 19 publications

(7 citation statements)

References 27 publications

(42 reference statements)

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“…However, multiple studies in humans investigating the incidence of Peyronie's disease after penile fracture or in patients with a long history of forcefully bending the erect penis (taqaandan) did not show a correlation between trauma and Peyronie's disease 151,152 . This observation might suggest that several unknown genetic factors are involved in the development of Peyronie's disease.…”

Section: Nature Reviews | Urologymentioning

confidence: 99%

The mechanisms and potential of stem cell therapy for penile fibrosis

2018

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| Fibrosis is often caused by chronic tissue injury leading to a persisting inflammatory response with excessive accumulation of extracellular connective tissue proteins. Peyronie's disease, urethral stricture and penile (corpora cavernosa) fibrosis are localized fibrotic disorders of the penile connective tissues that can substantially impair a patient's quality of life. Research over the past few decades has revealed the ability of stem cells to secrete a wide range of paracrine factors, a characteristic that could be exploited therapeutically to prevent and treat several inflammatory and fibrotic diseases. In preclinical studies, mesenchymal stem cells (MSCs) have proven to be the most effective and readily available type of stem cells for therapeutic use. An important advantage of MSCs is their ability to circumvent the immune system and function as immunomodulatory 'drug stores' to influence multiple cell types simultaneously. Many studies using stem cells have been applied exclusively to corpora cavernosa fibrosis owing to its well-established disease models. A plethora of preclinical data suggest the benefit of stem cells for use in penile fibrosis. However, their exact mechanism of action and optimal timing and mode of administration must be determined before clinical translation.

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Section: Nature Reviews | Urologymentioning

confidence: 99%

The mechanisms and potential of stem cell therapy for penile fibrosis

2018

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“…[1][2][3][4] The disease is postulated to be initiated by repetitive minor traumas to the fully or partially erect penis. 5 Main symptoms of the acute disease phase are increasing plaques and deviation, in combination with pain. 1 In the stable phase of PD, which usually begins 12 months from onset, deviation and plaques remain stable while deviation is the main symptom.…”

Section: Introductionmentioning

confidence: 99%

Surgical therapy of Peyronie’s disease by partial plaque excision and grafting with collagen fleece: feasibility study of a new technique

2013

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Surgery is gold-standard for correction of Peyronie's curvature. Grafting is preferred in advanced deviations. We present our novel surgical technique and early results of grafting with collagen fleece. Patients with stable Peyronie's disease (PD) were included. Grafting was performed by a ready-to-use collagen fleece coated with tissue sealant (TachoSil, Nycomed, Konstanz, Germany), following partial plaque excision/incision. Results of correction were documented by artificial erection. In all, n=70 consecutive patients underwent surgery. Mean patient age was 56.4 years (range: 33-72); 88.6% of patients had dorsal deviation, 11.4% lateral or ventral deviation. Grafting after partial plaque excision was performed in 61 patients (87.1%), after plaque incision in 2 (2.9%) patients. In the former patients, mean operative time was 94.2 min (range: 65-165). Totally straightness was achieved in 83.6%. Three patients required surgical drainage because of subcutaneous haematoma formation. After mean early follow-up of 5.2 days (range: 2-15), glans sensation was normal in 56 patients (91.8%). Seven patients (10.0%) underwent Nesbit procedure alone. Grafting by collagen fleece in PD is feasible and promising. Major advantages are decreased operative times and easy application. Moreover, an additional haemostatic effect is provided. However, long-term clinical outcomes are necessary to confirm these encouraging findings.

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“…This method only led to the formation of the acute inflammatory response and the tissue structure returned to normal after the acute phase. Acikgoz et al [29] and Zargooshi et al [30] also discovered that single trauma to penile albuginea would not lead to PD via prospective studies one after another. However, a latest meta-analysis has shown that penile fracture, a kind of penile trauma, could result in ED, penile plaques and curvature, though the incidence of these complications was only approximately 13% [31].…”

Section: Discussionmentioning

confidence: 99%

Repeated Micro-Trauma of the Penile Tunica Albuginea: A New Animal Model of Peyronie's Disease

et al. 2017

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Objectives: To compare effects of repairing injured tunica albuginea (PTA) of rat penis by single or repeated local injections of chlorhexidine ethanol (ChE) into the PTA and to establish a new animal model of Peyronie's disease (PD). Materials and Methods: Forty-two rats were divided into 7 groups. Rats either served as the normal control group with 1-5 injections of 0.9% saline or they received a single injection, 2, 3, 4, or 5 injections of ChE (0.1% chlorhexidine gluconate plus 15% ethanol dissolved in saline); rats in the positive control group were injected with TGF-β1. At 60 days after the last injection, the intracavernous pressure, degree of penile curvature, and histology were evaluated. Results: Compared with the single injection of the ChE group, we found the following in the repeat ChE injections groups: an increase in the degree of penile curvature, fibrous plaques in the PTA and/or corpus cavernosum, broken elastic fibers, slightly decreased erectile function, and an increased expression of TGF-β1 and αSMA. Conclusions: Repeated ChE injuries of PTA may lead to fibrosis. This represents an excellent model of PD that involves repeated injections of ChE into the local PTA as well as reveals the pathophysiologic mechanism of PD.

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Relationship between penile fracture and Peyronie's disease: a prospective study

Cited by 19 publications

References 27 publications

The mechanisms and potential of stem cell therapy for penile fibrosis

The mechanisms and potential of stem cell therapy for penile fibrosis

Surgical therapy of Peyronie’s disease by partial plaque excision and grafting with collagen fleece: feasibility study of a new technique

Repeated Micro-Trauma of the Penile Tunica Albuginea: A New Animal Model of Peyronie's Disease

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