.001) were significantly related to presenteeism. Individual factors were found to be directly correlated with stress-related factors at work (β =0.22, p<0.001). Significant indirect effects between stress-related factors at work and presenteeism (Sobel z=−6.61; p<0.001) and between individual factors and presenteeism (Sobel z=−4.42; p<0.001), which were mediated by health, were also found. Overall, the final model accounted for 37% (R 2 =0.37) of the variance in presenteeism. Conclusions: Our study indicates some important and practical guidelines for employers to avoid the burdens of stress-related presenteeism among their employees. These findings could help select target factors in the design and implementation of effective presenteeism interventions in the aging working population. (J Occup Health 2016; 58: 25−35)