Relationship between periodontitis and risk of cardiovascular disease: Insights from the Tromsø Study

Petrenya, Natalia; Hopstock, Laila Arnesdatter; Holde, Gro Eirin; Oscarson, Nils; Jönsson, Birgitta

doi:10.1002/jper.22-0004

Cited by 11 publications

(13 citation statements)

References 55 publications

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“…Periodontitis Grade B/C was linked to a higher overall cardiovascular risk, and this association was not explained by smoking confounding in participants aged 65-74 years, according to Petrenya et al (93). They also recommended that patients with periodontitis, particularly those with extensive alveolar bone loss, use NORRISK 2 score for cardiovascular risk assessment.…”

Section: Neoteric Substantiation Of Cvd and Pdmentioning

confidence: 99%

Association between cardiovascular diseases and periodontal disease: more than what meets the eye

Shetty

Fazal

Khan

et al. 2023

dti

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Cardiovascular diseases (CVDs) are inflammatory diseases of coronary arteries accompanying atheroma formation that can spawn impairment and, in severe cases, death. CVDs are the leading cause of death in the world. In recent decades, investigators have focused their impact on CVD by periodontal disease (PD). PD is a risk factor that can trigger the formation, maturation, and instability of atheroma in the arteries. Two mechanisms have been proposed to explain this relationship: periodontopathic pathogens explicitly invade the circulation or indirectly increase systemic levels of inflammatory mediators. It has been suggested that improvement in disease state has a positive effect on others. This review summarizes evidence from epidemiological studies as well as researches focusing on potential causation channels to deliver a comprehensive representation of the relationship between PD and CVD.

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Section: Neoteric Substantiation Of Cvd and Pdmentioning

confidence: 99%

Association between cardiovascular diseases and periodontal disease: more than what meets the eye

Shetty

Fazal

Khan

et al. 2023

dti

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“…In this cross-sectional study, we used data from the seventh survey tist trained before the study. Periodontal measurements were calibrated twice, as previously described (Petrenya et al, 2022).…”

Section: Study Design and Participantsmentioning

confidence: 99%

Are dental visiting patterns and oral pain associated with dental disease among Norwegian adults? A cross‐sectional study based on the Tromsø study

Nermo

Hadler‐Olsen

2023

Clinical & Exp Dental Res

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ObjectivesThe present study aims to describe the dental visiting patterns in a Norwegian adult population and their associations with sociodemographic and oral health variables, including oral pain. We further explore if the utilization of dental health services and oral pain predicts caries and periodontitis, the most common oral diseases.Materials and MethodsWe use data from the seventh wave of the Tromsø study performed in 2015–2016. In this cross‐sectional survey, all residents 40 years or older in Tromsø municipality in Norway were invited, of whom 21,083 (65%) participated. All participants answered questionnaires assessing sociodemographic characteristics, use of health services, and self‐reported health measures, including pain. Almost 4000 participants underwent a dental examination with registration of caries and periodontitis. Associations of dental visiting patterns and utilization of dental services the past 12 months with sociodemographic‐, self‐reported‐, and clinical oral health measures were analyzed by cross‐tabulation and Pearson's χ2 tests, as well as with logistic regression analyses with caries and periodontitis as outcomes.ResultsA regular, annual dental visiting pattern was the most common, but among respondents with severe dental anxiety and poor dental health, visiting for acute problems only or never (symptomatic visiting) was the most common. Intervals of more than 24 months between visits and a symptomatic visiting pattern were associated with caries, whereas shorter than 12‐month intervals and a symptomatic visiting pattern were associated with periodontitis. Many characteristics were shared among respondents with the lowest and the highest utilization of dental services, including oral pain, a difficult financial situation and poorer self‐reported and clinical dental health.ConclusionsRegular dental visits at 12–24 month intervals were associated with beneficial oral health parameters, compared with more frequent, rarer, and symptomatic dental visiting patterns. Oral pain was an unreliable predictor of caries and periodontitis.

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“…A low-grade inflammation, that is, hs-CRP≥3 mg/L has been reported in individuals with periodontitis. 31 History of cardiovascular diseases (CVD, including myocardial infarction or stroke), cancer, and rheumatoid arthritis was based on questionnaires. General health was categorized as excellent/good, neither good nor bad (moderate), and very bad/bad.…”

Section: Behavioral- Medical-and Dental-related Parametersmentioning

confidence: 99%

Polymorphism in epigenetic regulating genes in relation to periodontitis, number of teeth, and levels of high‐sensitivity C‐reactive protein and glycated hemoglobin: The Tromsø Study 2015‐2016

Asa’ad

Petrenya

Jönsson

et al. 2023

Journal of Periodontology

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BackgroundThe aim of this study was to investigate the association between periodontitis and four single nucleotide polymorphisms (SNPs) in genes involved in epigenetic regulation of DNA, and between these same SNPs and tooth loss, high‐sensitivity C‐reactive protein (hs‐CRP), and glycated hemoglobin (HbA1c) levels.MethodsWe included participants with periodontal examination (n = 3633, aged: 40–93 years) from the Tromsø Study seventh survey (2015–2016), Norway. Periodontitis was defined according to the 2017 AAP/EFP classification system as no periodontitis, grades A, B, or C. Salivary DNA was extracted and genotyping was performed to investigate four SNPs (rs2288349, rs35474715, rs34023346, and rs10010325) in the sequence of the genes DNMT1, IDH2, TET1, and TET2. Association between SNPs and periodontitis was analyzed by logistic regression adjusted for age, sex, and smoking. Subgroup analyses on participants aged 40–49 years were performed.ResultsIn participants aged 40‐49 years, homozygous carriage of minor A‐allele of rs2288349 (DNMT1) was associated with decreased susceptibility to periodontitis (grade A: odds ratio [OR] 0.55; p = 0.014: grade B/C OR 0.48; p = 0.004). The minor A‐allele of rs10010325 (TET2) was associated with increased susceptibility to periodontitis (grade A OR 1.69; p = 0.035: grade B/C OR 1.90; p = 0.014). In the entire sample, homozygous carriage of the G‐allele of rs35474715 (IDH2) was associated with having ≤24 teeth (OR 1.31; p = 0.018). Homozygous carriage of the A‐allele of TET2 was associated with hs‐CRP≥3 mg/L (OR 1.37; p = 0.025) and HbA1c≥6.5% (OR 1.62; p = 0.028).ConclusionsIn this Norwegian population, there were associations between polymorphism in genes related to DNA methylation and periodontitis, tooth loss, low‐grade inflammation, and hyperglycemia.

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Relationship between periodontitis and risk of cardiovascular disease: Insights from the Tromsø Study

Cited by 11 publications

References 55 publications

Association between cardiovascular diseases and periodontal disease: more than what meets the eye

Association between cardiovascular diseases and periodontal disease: more than what meets the eye

Are dental visiting patterns and oral pain associated with dental disease among Norwegian adults? A cross‐sectional study based on the Tromsø study

Polymorphism in epigenetic regulating genes in relation to periodontitis, number of teeth, and levels of high‐sensitivity C‐reactive protein and glycated hemoglobin: The Tromsø Study 2015‐2016

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