Relationship between personality and debrisoquine hydroxylation capacity

Abstract

We administered the Karolinska Scales of Personality to 225 healthy subjects in Spain selected from a group of 925 individuals previously phenotyped with regard to their capacity to hydroxylate debrisoquine. A significant relationship was found between the scores in as many as 4 of the 15 subscales (psychic anxiety, psychasthenia, inhibition of aggression and socialization) and the debrisoquine hydroxylation capacity. Poor metabolizers were more anxiety-prone and less successfully socialized than extensive metabolizers of debrisoquine. This and a previous study among subjects in Sweden suggest that there may be a relationship between personality and the activity of the enzyme hydroxylating debrisoquine (cytochrome P4502D6). This polymorphic enzyme may have an endogenous neuroactive substrate or product, such as a biogenic neurotransmitter amine.

Moderate-Vigorous Physical Activity across Body Mass Index in Females: Moderating Effect of Endocannabinoids and Temperament

“…An inverse relationship was observed between CB1 receptor availability and Novelty seeking [31]. Further, AEA has been identified as a substrate of the cytochrome P450 2D6 [32], and genotypic variations of this enzyme have been linked to individual differences in Harm avoidance, socialization ability, and anxiety [33]. Navarrete et al [34] compared the genetic expression of dopamine (DRD2) and cannabinoid (CB1, CB2) receptors in two mouse strains, observing that the mouse strain displaying greater motor behavior also presented more exploratory behavior, impulsivity, and lower attention capacity, and that these were related to CB2 receptor regulation.…”

Links among Paroxetine-Induced Sexual Dysfunctions, Gender, and CYP2D6 Activity

“…Long-term administration of strong inhibitors CYP2D6, in this case paroxetine, could account for the transition from an extensive to slow metabolic phenotype in 6 of the 11 men and 16 of the 25 women, as described in pharmacological literature (Brosen et al, 1993;Kohler et al, 1997;Llerena et al, 1993;Preskorn & Magnus, 1994;Sindrup et al, 1992;Spina et al, 1997). The patients did not take any other CYP2D6 inhibitors.…”

Relationship Between CYP 2D6 Metabolic Status and Sexual Dysfunction in Paroxetine Treatment

“…On the basis of a study published in Scandinavia (Bertilsson, Henthorn, & Sanz, 1989) that compared personality traits of CYP 2D6 EMs and PMs, Llerena et al (1993) compared individuals with different CYP 2D6 metabolic status and personality traits. After examining 39 PMs and 129 EMs, they concluded that PMs tend to be more predisposed to anxiety and are less successfully socialized.…”