Relationship between polymorphisms near the IL28B gene and spontaneous HBsAg seroclearance: a systematic review and meta‐analysis

Abstract

Polymorphisms near the interleukin (IL) 28B gene have been proposed to be associated with spontaneous clearance of the hepatitis C virus. The purpose of this study was to assess the relationship between IL28B polymorphisms and the rate of spontaneous hepatitis B surface antigen (HBsAg) seroclearance by means of meta-analysis. MEDLINE/PubMed and EMBASE were utilized to identify relevant studies. Odds ratio (OR) and 95% confidence interval (CI) were analysed together to assess the strength of the association. Subgroup analyses were mainly performed according to ethnicity. A total of 4028 cases with persistent chronic hepatitis B and 2327 spontaneously recovered controls were included from 11 studies. The single nucleotide polymorphism (SNP), rs12979860, had no significant association with HBsAg seroclearance (OR = 0.98, 95% CI: 0.84-1.14 in the dominant model; OR = 1.00, 95% CI: 0.68-1.46 in the recessive model; and OR = 0.95, 95% CI: 0.82-1.09 in the allelic model). The SNP, rs12980275, had no significant association either (OR = 1.03, 95% CI: 0.84-1.26 in the dominant model; OR = 1.17, 95% CI: 0.46-2.96 in the recessive model; and OR = 1.04, 95% CI: 0.86-1.26 in the allelic model), nor did the SNP, rs8099917 (OR = 0.94, 95% CI: 0.77-1.15 in the dominant model; OR = 0.74, 95% CI: 0.34-1.62 in the recessive model; and OR = 0.93, 95% CI: 0.77-1.13 in the allelic model). Similarly, the results of subgroup analyses by ethnicity also showed no association in either the Asian group or non-Asian group. We concluded that there was no significant association between common IL28B polymorphisms and the rate of spontaneous HBsAg seroclearance.

Association of HLA‐DP/DQ, STAT4 and IL‐28B variants with HBV viral clearance in Tibetans and Uygurs in China

“…As for IL‐28B polymorphisms, it seemed not to be associated with HBV natural clearance from our study, and this study again attest what we concluded previously . Also this has been validated in a recent meta‐analysis . Besides, haplotype analysis again consolidated this conclusion, which showed the trueness of our results (Tables and ).…”

Association between IL28B Polymorphisms and Outcomes of Hepatitis B Virus Infection: A meta-analysis

“…This study is the first systematic review that included all relevant eligible English publications in the recent 8 years. Meanwhile, it had a larger sample size comprising 5587 cases and 4295 than previous studies [36,37]. Previous studies investigating these associations may have included low-quality publications [38,39].…”

Effect of IL-28B Polymorphisms on the Natural Course of HBV Infection

“…HBV ile enfekte hücrelerde, transmembran reseptörüne bağlanan IFN-λ, MHC sınıf I antijen ekspresyonunu artırır ve JAK-STAT sinyal yolağını uyarır 6 . İnsan hepatoma hücrelerinde, yüksek konsantrasyonda IFN-λ ile HBV replikasyonunun %30 oranında azaltıldığı gösterilmiş olmakla birlikte, IFN-λ'nın HBV'ye karşı antiviral aktivitesinin sınırlı olduğu bildirilmektedir 7 . Bu durum, IFN-λ'nın kodlandığı IL-28B genindeki C/T allel dağılımı ile ilişkili olabilir.…”