Relationship between Porphyria Cutanea Tarda (PCT) and Viral Hepatitis

Tsukazaki, N; Tanaka, Keiichi; Irifune, Hiroko; Yoshida, Hiroyuki; Watanabe, Masahisa; Ohgami, Taro; Nonaka, Shigeo

doi:10.1111/j.1346-8138.1994.tb01764.x

Cited by 9 publications

(2 citation statements)

References 7 publications

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“…A low prevalence (8±23%) is found in Northern Europe, including Germany [18], Ireland [19] and the Netherlands [20]. A variable prevalence of antibodies against HCV is found in USA [21], Japan [22], Chile [23] and in Australia [24]. In a cohort of HCV-infected patients studied by Conry-Cantilena et al [25], 1.3% [2/152] had PCT, compared with 0.004% of the general population.…”

Section: Introductionmentioning

confidence: 99%

Hepatic porphyrin concentration and uroporphyrinogen decarboxylase activity in hepatitis C virus infection

et al. 2001

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Previous studies have shown a high prevalence of hepatitis C virus (HCV) infection in patients with porphyria cutanea tarda (PCT). The aim of this study was to assess hepatic porphyrin concentrations (HPC) and hepatic uroporphyrinogen decarboxylase (UROD) activity in HCV-infected patients free of PCT. Thirty-two HCV-infected patients (20 M, 12 F, mean age 51 years) and seven control patients (4 M, 3 F, mean age 59 years) free of liver disease, were studied. Knodell's score was determined on liver biopsy by two independent anatomopathologists. Measurement of HPC and hepatic UROD activity levels were carried out on liver biopsy. Relative to controls, HCV-infected patients had high HPC levels (mean +/- SD: 47 +/- 20 vs. 17 +/- 6 pmol/mg protein, P < 0.001) and low hepatic UROD activity levels (514 +/- 95 vs. 619 +/- 125 pmol Copro/h/mg protein, P < 0.05). HPC was not correlated with hepatic UROD activity and the increase was due to coproporphyrin accumulation. No correlation was observed between HPC or hepatic UROD activity values and HCV-RNA concentrations, Knodell's score, hepatic fibrosis, periportal necrosis, periportal inflammation or hepatic iron content in HCV-infected patients. Hepatocellular necrosis was significantly correlated with HPC value (P < 0.005). Hence, in HCV-infected patients, HPC is significantly increased and hepatic UROD activity is very slightly decreased as compared to controls. HPC values and UROD activity are not correlated with HCV-RNA concentrations, hepatic iron content and hepatic fibrosis. The small increase in HPC values in hepatitis C infection is linked with hepatic injury and not with a direct effect on hepatic UROD enzyme.

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Section: Introductionmentioning

confidence: 99%

Hepatic porphyrin concentration and uroporphyrinogen decarboxylase activity in hepatitis C virus infection

et al. 2001

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show abstract

“…A low prevalence (8–23%) is found in Northern Europe, including Germany [18], Ireland [19] and the Netherlands [20]. A variable prevalence of antibodies against HCV is found in USA [21], Japan [22], Chile [23] and in Australia [24]. In a cohort of HCV‐infected patients studied by Conry‐Cantilena et al .…”

Section: Introductionmentioning

confidence: 99%

Hepatic porphyrin concentration and uroporphyrinogen decarboxylase activity in hepatitis C virus infection

Brudieux

Lédinghen

Morán³

et al. 2001

Journal of Viral Hepatitis

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Previous studies have shown a high prevalence of hepatitis C virus (HCV) infection in patients with porphyria cutanea tarda (PCT). The aim of this study was to assess hepatic porphyrin concentrations (HPC) and hepatic uroporphyrinogen decarboxylase (UROD) activity in HCV‐infected patients free of PCT. Thirty‐two HCV‐infected patients (20 M, 12 F, mean age 51 years) and seven control patients (4 M, 3 F, mean age 59 years) free of liver disease, were studied. Knodell’s score was determined on liver biopsy by two independent anatomopathologists. Measurement of HPC and hepatic UROD activity levels were carried out on liver biopsy. Relative to controls, HCV‐infected patients had high HPC levels (mean ± SD: 47 ± 20 vs. 17 ± 6 pmol/mg protein, P < 0.001) and low hepatic UROD activity levels (514 ± 95 vs. 619 ± 125 pmol Copro/h/mg protein, P < 0.05). HPC was not correlated with hepatic UROD activity and the increase was due to coproporphyrin accumulation. No correlation was observed between HPC or hepatic UROD activity values and HCV‐RNA concentrations, Knodell’s score, hepatic fibrosis, periportal necrosis, periportal inflammation or hepatic iron content in HCV‐infected patients. Hepatocellular necrosis was significantly correlated with HPC value (P < 0.005). Hence, in HCV‐infected patients, HPC is significantly increased and hepatic UROD activity is very slightly decreased as compared to controls. HPC values and UROD activity are not correlated with HCV‐RNA concentrations, hepatic iron content and hepatic fibrosis. The small increase in HPC values in hepatitis C infection is linked with hepatic injury and not with a direct effect on hepatic UROD enzyme.

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Hepatitis C as a systemic disease: virus and host immunologic responses underlie hepatic and extrahepatic manifestations

2007

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Relationship between Porphyria Cutanea Tarda (PCT) and Viral Hepatitis

Cited by 9 publications

References 7 publications

Hepatic porphyrin concentration and uroporphyrinogen decarboxylase activity in hepatitis C virus infection

Hepatic porphyrin concentration and uroporphyrinogen decarboxylase activity in hepatitis C virus infection

Hepatic porphyrin concentration and uroporphyrinogen decarboxylase activity in hepatitis C virus infection

Hepatitis C as a systemic disease: virus and host immunologic responses underlie hepatic and extrahepatic manifestations

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