2021
DOI: 10.1167/tvst.10.7.15
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Relationship Between Prolonged Intraocular Inflammation and Macular Edema After Cataract Surgery

Abstract: Purpose To assess whether aqueous flare is related to an increased risk of pseudophakic cystoid macular edema (PCME) following uneventful cataract surgery in nondiabetic and diabetic patients. Methods A post hoc analysis of five consecutive randomized clinical trials in the Department of Ophthalmology, Kymenlaakso Central Hospital, Finland. Aqueous flare levels were recorded in 448 eyes of 448 patients before surgery, and after the course of topical anti-inflammatory tr… Show more

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Cited by 8 publications
(8 citation statements)
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“…It is proven that macular thickness increases after uncomplicated phacoemulsification when compared with healthy contralateral eyes, usually without visual acuity deterioration, and after 6-8 weeks from the operation it gradually declines [31]. The pathogenesis of PCME remains unknown but it is hypothesized that it is a result of inflammation [32 ]. PCME rate was reported to be higher when intracapsular or extracapsular cataract extraction technique was used [29] but it is accepted that the incidence of PCME has reduced significantly because of the refinement in cataract surgical techniques, including the switch from extracapsular cataract surgery to phacoemulsification.…”
Section: Pseudophakic Cystoid Macular Oedemamentioning
confidence: 99%
See 1 more Smart Citation
“…It is proven that macular thickness increases after uncomplicated phacoemulsification when compared with healthy contralateral eyes, usually without visual acuity deterioration, and after 6-8 weeks from the operation it gradually declines [31]. The pathogenesis of PCME remains unknown but it is hypothesized that it is a result of inflammation [32 ]. PCME rate was reported to be higher when intracapsular or extracapsular cataract extraction technique was used [29] but it is accepted that the incidence of PCME has reduced significantly because of the refinement in cataract surgical techniques, including the switch from extracapsular cataract surgery to phacoemulsification.…”
Section: Pseudophakic Cystoid Macular Oedemamentioning
confidence: 99%
“…It is proven that macular thickness increases after uncomplicated phacoemulsification when compared with healthy contralateral eyes, usually without visual acuity deterioration, and after 6–8 weeks from the operation it gradually declines [31]. The pathogenesis of PCME remains unknown but it is hypothesized that it is a result of inflammation [32 ▪ ].…”
Section: Pseudophakic Cystoid Macular Oedemamentioning
confidence: 99%
“…An association between increased aqueous flare and macular thickening was found after an uneventful cataract operation. 19,20 High flare levels were found in central retinal vein occlusion, 21 and the levels correlated with the disease activity in wet AMD. 22…”
Section: Introductionmentioning
confidence: 96%
“…An association between increased aqueous flare and macular thickening was found after an uneventful cataract operation. 19,20 High flare levels were found in central retinal vein occlusion, 21 and the levels correlated with the disease activity in wet AMD. 22 Blood-ocular-barrier disruption could potentially be the link between increased levels of periodontal endotoxins and the risk for retinal diseases.…”
Section: Introductionmentioning
confidence: 96%
“…Frequent intravitreal injections of anti-VEGF medicines are often required to keep long-term vision, increasing the risk of endophthalmitis and healthcare expenditures [11]. The switching from anti-VEGF medications to corticosteroids often improves the therapeutic outcome in the long-term [12,13], but intravitreal steroids can cause high intraocular pressure and cataract [14][15][16]. The treatment of DME requires affordable, safe and effective therapeutic options.…”
Section: Introductionmentioning
confidence: 99%